Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday 11 April 2018

Pomegranates Consumers: Enjoy 20 Health Benefits But Beware of 3 Critical Adverse-Effects, According to PubMed

By Kyle J. Norton

Pomegranates, cultivated in Asian since ancient time. is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran.

I. Nutrients
1. Dietary fiber
Daily intake of right amount of fibers can prvent and treat
a. Diabetes, as Increased consumption of vegetables, whole grains, and soluble and insoluble fiber is associated with improved glucose metabolism in both diabetic and nondiabetic individuals. Improvements in insulin sensitivity and glucose homeostasis were more evident in participants following a plant-based diet compared with other commonly used diets, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F.(1)

b. Cholesterol and cardiovascular diseases, as the soluble fiber content of legumes and vegetables has also been shown to decrease LDL-C. Current investigations continue to explore this area in depth and examine potential synergies between dietary fiber and other phytochemicals that may lower cholesterol, according to the study of "Effects of soluble dietary fiber on low-density lipoprotein cholesterol and coronary heart disease risk" by Bazzano LA.(2)
2. Protein
3. Thiamine (vitamin B1)
4. Riboflavin (vitamin B2)
5. Niacin (vitamin B3)
6. Pantothenic acid (vitamin B5)
7. Vitamin B6
8. Folate (vitamin B9)
9. Vitamin C
10. Calcium
11. Iron
12. Magnesium
13. Phosphorus
14. Potassium
15. Zinc
16. Etc.

II. Health Benefits
A. Health benefits according to researches
[1]. Anti - Cancers
In the investigation of phytochemicals and pomegranate extracts of the fruit of the Punica granatum (pomegranate) and theirs antioxidant effects found that due to the action of ellagic acid, the main polyphenol in pomegranate. In this mini review the effects of pomegranate extracts and ellagic acid on the proliferation of prostate cancer cells and their future potential are discussed, according to "Ellagic acid, pomegranate and prostate cancer -- a mini review" by Bell C, Hawthorne S.(a)

[2] Antiproliferative, [3]apoptotic and [4] antioxidant activities
In the assessment of polyphenols including punicalagin, the major fruit ellagitannin, and ellagic acid (EA) of Pomegranate (Punica granatum L.) fruits juice (PJ) and its antioxidant and anti-atherosclerotic activities found that Pomegranate juice showed greatest antiproliferative activity against all cell lines by inhibiting proliferation from 30% to 100%. At 100 microg/ml, PJ, EA, punicalagin and TPT induced apoptosis in HT-29 colon cells. However, in the HCT116 colon cells, EA, punicalagin and TPT but not PJ induced apoptosis. The trend in antioxidant activity was PJ>TPT>punicalagin>EA. The superior bioactivity of PJ compared to its purified polyphenols illustrated the multifactorial effects and chemical synergy of the action of multiple compounds compared to single purified active ingredients, according to "In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice" by Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D.(b)

[5]. Osteoarthritis
In the evaluation of extract of omegranate and its effect on p38-MAPK which is a major signal-transducing pathway in osteoarthritis (OA) concluded that our results provide an important insight into the molecular basis of the reported cartilage protective and arthritis inhibitory effects of pomegranate extract. These novel pharmacological actions of PE on IL-1β stimulated human OA chondrocytes impart a new suggestion that PE or PE-derived compounds may be developed as MKK and p38-MAPK inhibitors for the treatment of OA and other degenerative/inflammatory diseases, according to "Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes" by Rasheed Z, Akhtar N, Haqqi TM.(c)

[6]. Rheumatoid arthritis
In the analyzing the Pomegranate extract (POMx) and its effect on the incidence and severity of collagen-induced arthritis in mice, found that pomegranate consumption reduced DAS28 in RA patients, and this effect could be related to the antioxidative property of pomegranates. Dietary supplementation with pomegranates may be a useful complementary strategy to attenuate clinical symptoms in RA patients, according to "Consumption of pomegranate decreases serum oxidative stress and reduces disease activity in patients with active rheumatoid arthritis: a pilot study" by Balbir-Gurman A, Fuhrman B, Braun-Moscovici Y, Markovits D, Aviram M.(d)

[7]. Obesity
In the research of evaluate the effect of pomegranate juice on insulin secretion and sensitivity in patients with obesity found that Pomegranate juice administration for 1 month did not modify insulin secretion and sensitivity in patients with obesity; however, the natural evolution to increased weight and adiposity was halted, according to "Effect of pomegranate juice on insulin secretion and sensitivity in patients with obesity" by González-Ortiz M, Martínez-Abundis E, Espinel-Bermúdez MC, Pérez-Rubio KG.(e)

B. Health benefits according to concentration
[8]. Dietary fiber
Daily intake of right amount of fibers can prvent and treat
a. Diabetes, as Increased consumption of vegetables, whole grains, and soluble and insoluble fiber is associated with improved glucose metabolism in both diabetic and nondiabetic individuals. Improvements in insulin sensitivity and glucose homeostasis were more evident in participants following a plant-based diet compared with other commonly used diets, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F.(1)

[9]. Cholesterol and [10] cardiovascular diseases, as the soluble fiber content of legumes and vegetables has also been shown to decrease LDL-C. Current investigations continue to explore this area in depth and examine potential synergies between dietary fiber and other phytochemicals that may lower cholesterol, according to the study of "Effects of soluble dietary fiber on low-density lipoprotein cholesterol and coronary heart disease risk" by Bazzano LA.(2)

[11]. Vitamin C
In the evaluation of pulmonary dysfunction. and it effects on pulmonary dysfunction found that At present, evidence from randomised-controlled trials is insufficient to recommend a specific role for vitamin C in the treatment of asthma. Further methodologically strong and large-scale randomised controlled trials are needed in order to address the question of the effectiveness of vitamin C in children with asthma but some outcome data showed effectiveness on lung function, symptom scores, IgE levels and inhaled steroid use. One small study showed a significant difference in % drop in FEV1 post-exercise, according to the study of "Vitamin C supplementation for asthma" by Kaur B, Rowe BH, Arnold E.(3)

[12]. Folate
Folate beside is important for the production of red blood cells, and for the proper development of the brain, it also helps to enhance the replication and maintain DNA and RNA, thus reducing the risk of birth defects, in a study of "Go folic!" by Bland J., posted in PubMed, researchers state that in order to prevent neural tube defects (NTDs), and proactively prevent new cases of spina bifida and hydrocephalus, it is essential that women take folic acid well before becoming pregnant. Through the use of social networks, and the voice of healthcare professionals, it is hoped that more women than ever before will receive the Go Folic! message and start taking the 400mcg/day required to ensure the development of a healthy brain and spine.

[13]. Vitamin B5
Vitamin B5 not only plays an important role in speeding wound healing , according to ""Role of pantothenic and ascorbic acid in wound healing processes: in vitro study on fibroblasts" by Lacroix B, Didier E, Grenier JF.,(4), but also enhances the healing of diabetic ulceration, according to "Safety and efficacy of a new honey ointment on diabetic foot ulcers: a prospective pilot study" by Abdelatif M, Yakoot M, Etmaan M.(5)

[14]. Vitamin B1
Vitamin B1 beside is important supplement used to treat inflammatory diseases, according to ""Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages" by Yadav UC, Kalariya NM, Srivastava SK, Ramana KV.,(6), but also p;revent the risk of diabetic complication, according to "The potential role of thiamine (vitamin B1) in diabetic complications" by Thornalley PJ.(7)

[15]. Phosphorus
Phosphorus forms an important part of the process related to growth and maintenance of bones and teeth, according to the study of "Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice" by Sun W, Sun W, Liu J, Zhou X, Xiao Y, Karaplis A, Pollak MR, Brown E, Goltzman D, Miao D.(8)

C. Other Health benefits
[16]. Coronary heart disease
In the study of pomegranate juice consumption and its effects on coronary heart disease found that in subjects at moderate coronary heart disease risk, pomegranate juice consumption had no significant effect on overall CIMT progression rate but may have slowed CIMT progression in subjects with increased oxidative stress and disturbances in the TG-rich lipoprotein/HDL axis, according to "Effects of consumption of pomegranate juice on carotid intima-media thickness in men and women at moderate risk for coronary heart disease" by Davidson MH, Maki KC, Dicklin MR, Feinstein SB, Witchger M, Bell M, McGuire DK, Provost JC, Liker H, Aviram M.(I)

[17]. Cardiovascular health
In the classification of pomegranate juice consumption and its antioxidant effect on cardiovascular health found that some antioxidants have been shown to reduce blood pressure, the purpose of this review was to discover the effect of pomegranate juice consumption on blood pressure and cardiovascular health. Pomegranate juice consumption may reduce systolic blood pressure, inhibits serum ACE activity, and is convincingly a heart-healthy fruit [Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure, according to "The effects of pomegranate juice consumption on blood pressure and cardiovascular health" by Stowe CB.(II)

[18]. Diabetes
In the research of pomegranate consumption and its effect on diabetes found that despite a similar level of energy intake, HF mice had a greater concentration of leptin and a lower concentration of adiponectin compared to HF + POMo mice. POMo intake was associated with an improvement in insulin sensitivity, suggesting that risk of developing type 2 diabetes may have been reduced; however, CVD risk did not change., according to "Pomegranate seed oil consumption during a period of high-fat feeding reduces weight gain and reduces type 2 diabetes risk in CD-1 mice" by McFarlin BK, Strohacker KA, Kueht ML.(III)

[19]. Catechins

Catechin, a polyphenol found abundantly in Pomegranates has exerted its antioxidant effect in reducing the risk of forming of free radicals, according to "Catechins and procyanidins in berries of vaccinium species and their antioxidant activity" by Määttä-Riihinen KR, Kähkönen MP, Törrönen AR, Heinonen IM.(IV)

[20]. Kidney Protective effect
In the investigation of the effect of pomegranate seed oil (PSO) on HCBD-induced nephrotoxicity
found that PSO clearly attenuated HCBD-induced nephrotoxicity, but explanation and mechanism of this protection need further explorations, according to "Protective effect of pomegranate seed oil on hexachlorobutadiene-induced nephrotoxicity in rat kidneys" by Bouroshaki MT, Sadeghnia HR, Banihasan M, Yavari S.(V)

Beware of these Side Effects
1. Allergies to pomegranate may occur but are very rare, according ti the study, Mannitol contained in pomegranate has been identified as causing IgE-mediated hypersensitivity (*)

2. Pomegranates may interact with certain types of medication, through through activation of liver enzyme, please make sure you talk to your doctor if you are taking certain medication(*).

3. Whole pomegranate fruit extract may induce a genetic risk(*)

Sources

(*) Is pomegranate juice a potential perpetrator of clinical drug-drug interactions? Review of the in vitro, preclinical and clinical evidence y Srinivas NR(PubMed)

(*) Efficacy and Safety of Pomegranate Medicinal Products for Cancer by Christian Vlachojannis, 1 Benno F. Zimmermann, 2 , 3 and Sigrun Chrubasik-Hausmann(PMC)

Tuesday 10 April 2018

Better Than Chemo Cisplatin in Inhibited Onset and Gene Expression in Induction of Colon Cancer, According Online Medical Literature

Kyle J. Norton

Arnica may have a profound and therapeutic effect in ameliorated risk and treatment of colon cancer, some scientists suggested.

The results of the investigation were carried out by some respectable institutes, including the University of São Paulo and the University of Münster, and published on online medical literature.

Colon cancer is a medical condition characterized by cell growth irregularly and uncontrollably in the colon tissue. At the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.

In the study to re confirm the use of technique in detected the early stage of colon cancer through examine the expression of aberrant crypt foci (ACF) and colon rectal mucosal epithelial cell proliferation researchers at the the University of São Paulo conducted a experiment of 50 male Wistar rats randomly divided into 5 groups, as indicated below

* Groups G1 to G4 were given 4 injections of the carcinogen 1,2-dimethylhydrazine (DMH)

* The G2 group received Lychnophora ericoides (LE) extracts for 6 wk.

* The groups G3 and G4 received LE for 4 wk and 2 wk, respectively, at the postinitiation and initiation phases of colonic carcinogenesis. The group G5 was the control.

Observation at the 42th day after the first injections of DMH for the neoplasic induction, found that Arnica treatment group (LE), including G2, 3 and 4 demonstrated a statistically significant decrease in the number of aberrant crypt foci (ACF) and an reduction of cell proliferation induced by DMH.

These indications suggested that Arnica consisted a protective influence on the process of colon carcinogenesis, through suppressing both the initiation and the promotion of colonic carcinogenesis.

Furthermore, in the reexamine the cytotoxic activity of phytochemical compound isolated from Arnica, against COLO 320, a human colorectal cancer cell line using the microculture tetrazolium (MTT) assay, researcher found that isolated flavonoids showed moderate to low cytotoxicity, in compared to the reference compound cisplatin at 2.9 microM.

Cisplatin is a conventional chemo medication used to treat a number of cancers.

In 2 hours of injection, sesquiterpene lactones, helenalin at dose of 1.0 microM, possessing both the reactive alpha-methylene-gamma-lactone moiety and a reactive alpha,beta-unsubstituted cyclopentenone ring, displayed the strongest cytotoxicity against the tested colon cell line in compared to other compounds.

In compared to tested GLC4, a human small cell lung carcinoma cell line, COLO 320 was more sensitive to many flavonoids (especially for flavones), but more resistant to the cytotoxic effect of the sesquiterpene lactones.

Interestingly, in the evaluation of Arnica effect in deregulation of c-myb expression involved in the development of human tumors, especially certain types of leukemia and breast and colon cancer, researchers indicated that application of sesquiterpene lactones isolated from Arnica suppress Myb-dependent gene expression with potential anti-colon cancer activity with the IC50 values were in a range between 0.7 and >30 μM.

C-myb is a members of terminal domain with function in regulated the expression of hematopoiesis, cell proliferation, and differentiation in tumorigenesis.

In compared to other isolated bioactive compounds, furanoheliangolide goyazensolide and the pseudoguaianolide helenalin acetate with IC50 = 0.6 and 0.7 μM, respectively, represented the most active inhibitors of c-Myb dependent gene expression.

Observed by the control measurements for cell viability (MTS assay), researchers also found that c-Myb dependent gene expression is not a function of cytotoxicity/unspecific cell damage.

All these results indicated that Arnica processed a significant effect in prevented early onset, progression and treatment of colon cancer through it bioactive compounds in inhibited onset of aberrant crypt foci (ACF) and colon rectal mucosal epithelial cell and colon cancer cells proliferation and gene expression in risk of colon cancer.

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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The protective role of Lychnophora ericoides Mart. (Brazilian arnica) in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis by Fernandes CR1, Turatti A, Gouvea DR, Gobbo-Neto L, Diniz A, Ribeiro-Silva A, Lopes NP, Garcia SB.(PubMed)
(2) Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and the COLO 320 cell lines by Woerdenbag HJ1, Merfort I, Passreiter CM, Schmidt TJ, Willuhn G, van Uden W, Pras N, Kampinga HH, Konings AW.(PubMed)
(3) Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships by Schomburg C1, Schuehly W, Da Costa FB, Klempnauer KH, Schmidt TJ(PubMed)

Sunday 8 April 2018

Majority of Women Chose Cinnamon Over Acetaminophen in Relieved Menstrual Pain and Heavy Menstrual Bleeding, According PubMed

By Kyle J. Norton

Cinnamon is a spice derived from the inner bark of tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belongings to the family Lauraceae, use in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.

Topical use of essential oil extracted from cinnamon may be the next generation whole herb medicine for prevention and treatment of menstrual pain and heavy menstrual bleeding.

The results of the investigation were reported by several respectable institutes and published on the data bases of numbers online medical literature, including PubMed.

According to the Eulji University, in the study of compared the effect of aromatherapy massage and acetaminophen on menstrual pain in Korean high school girls. cinnamon treatment group showed a significantly higher reduction of menstrual pain than in the acetaminophen group.

Acetaminophen or APAP is a over-counter and popular conventional medicine used to treat pain and fever with numbers of intolerant adverse effects.

In a randomized, double-blind trial, out of 114, group received Cinnamon (capsule containing 420 mg Cinnamon, TDS, n= 38) in 24 h significantly reduced the severity and duration of pain during menstruation and menstrual bleeding.

In primary dysmenorrhea, cinnamon expressed significantly over reduction of pain, menstrual bleeding, nausea and vomiting with primary dysmenorrhea without side effects.

Dr. Marzouk TM., the lead author at the Mansoura University said, " ... aromatherapy abdominal massage once daily for seven days prior to menstruation using the essential oils (cinnamon....) is effective in alleviating menstrual pain, its duration and excessive menstrual bleeding...." and "Aromatherapy can be provided as a nonpharmacological pain relief measure and as a part of nursing care given to girls suffering of dysmenorrhea, or excessive menstrual bleeding".

Further study of the effect of cinnamon extract on symptoms of dysmenorrhea and contractility in some smooth muscles, Dr. Alotaibi M. suggested, cinnamon may be used to alleviate menstrual pain associated with dysmenorrhoea or prevent unwanted uterine activity in early pregnancy.

However, intake of cinnamon should be taken with care as toxicity was found in case of overdoses.

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You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Aromatherapy massage on the abdomen for alleviating menstrual pain in high school girls: a preliminary controlled clinical study by Hur MH1, Lee MS, Seong KY, Lee MK.(PubMed)
(2) Comparative effect of cinnamon and Ibuprofen for treatment of primary dysmenorrhea: a randomized double-blind clinical trial by Jaafarpour M1, Hatefi M2, Khani A3, Khajavikhan J4.(PubMed)
(3) The effect of cinnamon on menstrual bleeding and systemic symptoms with primary dysmenorrhea by Jaafarpour M1, Hatefi M2, Najafi F3, Khajavikhan J4, Khani A3.(PubMed)
(4) The effect of aromatherapy abdominal massage on alleviating menstrual pain in nursing students: a prospective randomized cross-over study by Marzouk TM1, El-Nemer AM, Baraka HN.(PubMed)
(5) The effect of cinnamon extract on isolated rat uterine strips by Alotaibi M1.(PubMed)

Saturday 7 April 2018

Better Than Chemo DuP-697 in Inhibited Immune Suppressor Prostaglandin (PG)E(2) for Treatment of Non Small Cell Lung Cancer

Arnica may have a therapeutic and potential effect in reduced risk and treatment of non small cell lung cancer, some scientists suggested.

The result of the efficacy was reported by numbers of investigation conduced by several respectable institutes, such as University of Groningen and Center for Cancer Research, Bethesda and published on online medical literature.

Lung cancer is a chronic and medical condition characterized by the irregular and controllable cell growth in the lung tissue.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.

According to the University of Groningen in the investigated cytotoxicity of 21 flavonoids and 5 sesquiterpene lactones presented in Arnica species on GLC4, a human small cell lung carcinoma cell line, using the microculture tetrazolium (MTT) assays.

* Application of compound cisplatin (IC50 = 1.1 microM and 2.9 microM showed a greatest inhibition of human small cell lung carcinoma cell line, through cytotoxitic activity in compared to most flavonoids isolated.

* The most toxic compound was the flavone jaceosidin on GLC4

* Helenalin, possessing both the reactive alpha-methylene-gamma-lactone moiety and a reactive alpha,beta-unsubstituted cyclopentenone ring, displayed the strongest cytotoxicity on GLC4.

Flavonoids processed significantly antioxidant and anti-inflammatory activities, according to online literature were found abundantly in tea, citrus fruit, citrus fruit juices, berries, red wine,....

And phytochemicals sesquiterpene lactones found in some herbs, such as Artichoke, Boneset Eupatorium perfoliatum, Burdock, Calea ternifolia, Chamomile,.... are also used for treatment of diseases associated to inflammatory, protozoal, bacterial and microbial infection.

Additionally, in the evaluated the effects of anethole dithiolethione modified valproate, diclofenac and sulindac isolated from Arnica on non-small cell lung cancer (NSCLC) cells, researchers found that injection of the bioactive chemicals exerted a potential anti lung cancer effect through inhibited the levels of prostaglandin (PG)E(2) in NSCLC cell lines A549 and NCI-H1299 in compared to the conventional medicine COX-2 inhibitor DuP-697.

Prostaglandin (PG)E(2) is linked to progression of several types of cancer through its tumor-associated inflammation in created an immunosuppressive microenvironment, allowing tumor cells to escape immunosurveillance.

Moreover, in compared to all anethole modificatiions in vivo, S-valproate and S-diclofenac, exerted a strong anti growth of A549 cells. but not S-sulindac.

S-valproate and S-diclofenac significantly inhibited A549 or NCI-H1299 xenograft proliferation in nude mice, but had no effect on the nude mouse body weight.

Dr. Moody TW, the lead author, after taking into comparable tests of all ingredients through Western blot, said, "S-valproate and S-diclofenac inhibit the growth of NSCLC cells and reduce PGE(2) levels, they may prove beneficial in the chemoprevention and/or therapy of NSCLC".

The information findings suggested that Arnica and its bioctive ingredients may be considered as a functional herb in prevention and combined with conventional standard therapy in stop progression and treatment of non small cell lung cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and the COLO 320 cell lines by Woerdenbag HJ1, Merfort I, Passreiter CM, Schmidt TJ, Willuhn G, van Uden W, Pras N, Kampinga HH, Konings AW.(PubMed)
(2) Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells by Moody TW1, Switzer C, Santana-Flores W, Ridnour LA, Berna M, Thill M, Jensen RT, Sparatore A, Del Soldato P, Yeh GC, Roberts DD, Giaccone G, Wink DA.(PubMed)
(3) A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia by Lam S1, MacAulay C, Le Riche JC, Dyachkova Y, Coldman A, Guillaud M, Hawk E, Christen MO, Gazdar AF.(PubMed)

Friday 6 April 2018

Enjoy Alfalfa 8 Health Benefits But Beware of 2 Hidden Side Effects, According to Medical Literature

A. Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc. North Americal aboriginal has used Alfalfa seed as food, such as making bread and mush.

B. Nutrients
1. Essential amino acids
2. Calcium
3. Magnesium
4. Potassium
5. Iron
6. Phosphorus
7. Zinc
8. Beta carotene
9. vitamin C
10. vitamins D
11.Vitamin E
12. Vitamin K
13. Etc.

C. Health benefits of Alfalfa
1. Antioxidant
In a study of measurements of pH, water holding capacity, color, oxymyoglobin content, TBARS and oxidation-reduction potential in evaluating the effects of a dietary protein-xanthophylls (PX) concentrate of alfalfa to turkey diets conducted by University of Life Sciences in Lublin, Skromna 8, 20-704 Lublin, Poland.(1), researchers found that TBARS and oxidation-reduction potential values suggested that the inclusion of the concentrate to turkey diets acts as an antioxidant in the raw meat.

2. Cholesterol
In a study to test the effect of Alfalfa used in traditional medicine to treat high blood cholesterol conducted by Malinow MR, McLaughlin P, Stafford C.(2), in 3 human volunteers during ingestion of diets containing alfalfaseeds (AS) for 3 weeks, researchers found that Plasma cholesterol concentrations were reduced and No signs of toxicity were detected through serum determinations of multiple parameters. The ingestion of AS in rats decreased the concentration of plasma cholesterol, reduced intestinal absorption of exogenous and endogenous cholesterol, and increased fecal biliary excretion.

3. Hyperlipoproteinemia
In a study of Fifteen patients with hyperlipoproteinemia (HLP), types IIA (n = 8), IIB (n = 3) and IV (n = 4) were given 40 g of heat prepared alfalfaseeds 3 times daily at mealtimes for 8 weeks with otherwise unchanged diet, conducted by Mölgaard J, von Schenck H, Olsson AG.(3), found that patients with type II HLP alfalfa treatment caused after 8 weeks a maximal lowering of pretreatment median values of total plasma cholesterol from 9.58 to 8.00 mmol/l (P less than 0.001) and low density lipoprotein (LDL) cholesterol from 7.69 to 6.33 mmol/l (P less than 0.01), which corresponds to decreases of 17% and 18%, respectively. Maximal decrease was 26% in total cholesterol and 30% in LDL cholesterol. In two patients with hypercholesterolemia the LDL cholesterol decreased less than 5%. Apolipoprotein B decreased in the same period from 2.17 to 1.43 g/l (P less than 0.05) in type II HLP, corresponding to 34% decrease, whereas apolipoprotein A-I did not change. Body weight increased slightly during the first 4 weeks of alfalfa treatment (P less than 0.001) probably because of the caloric content in the alfalfa seeds. After cessation of treatment, all lipoprotein concentrations returned to pretreatment levels. We conclude that alfalfa seeds can be added to the diet to help normalize serum cholesterol concentrations in patients with type II HLP.

4. Disease of autoimmune
In a study of five groups of 12-week-old female mice were per oral treated with vehicle (control), lyophilized AS (550 mg wt/kg BW), ASEA (ASEA, 25 mg/kg BW), coumestrol (CUM, 0.075 mg/kg BW) and tamoxifen (TAM, 0.375 mg/kg BW) as the positive control, conducted by Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei, Taiwan (4), researchers found that alhalfa decreased the disease severity, increased survival and life span of the autoimmune-prone MRL-lpr/lpr mice, suggesting a potential of ASEA in the treatment of autoimmune diseases.

5. Anti-inflammatory activity
In a study of anti-inflammatory effects may be used for inflammatory disorders by examining alfalfa sprout ethyl acetate extract (ASEA) in ,ice coducted by College of Life Science, National Taiwan University, Taipei, Taiwan, Republic of China.(5), researchers found that significantly higher survival rates than the control group and suggests that ASEA supplementation can suppress the production of pro-inflammatory cytokines and alleviate acute inflammatory hazards.

6. Systemic lupus erythematosus
In experimental studies in primates ingesting alfalfa sprout seeds and L-canavanine (a prominent amino acid constituent of alfalfa) is presented,conducted by Oregon Health Sciences University, Portland (6), researchers indicate that a potential toxic and immunoregulatory role of L-canavanine in the induction of a systemic lupus-like disease in primates.

7. Menopause symptoms
In a study of Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity, conducted by University of Illinois at Chicago (7), researchers found thatestrogenic components of plant extracts can be identified using assays for estrogenic activity along with screening and identification of the active components using ultrafiltration LC-MS. These data suggest a potential use for some dietary supplements, ingested by human beings, in the treatment of menopausal symptoms.

8. Neuroprotective activity
In a study of the neuroprotective effect of methanol extract of Medicago sativa (MS, Alfalfa) on ischemia and reperfusion-induced cerebral injury in mice, conducted by Institute of Pharmacy, Solan 173 223, India. (8)found that suggest that treatment with MS enhances the antioxidant defense against BCAO-induced global cerebral ischemia and exhibits neuroprotective activity.

9. Etc

D. Side effects
1. High amount of vitamin K may reduce the effectiveness of anticoagulant medicine(9)
2. Causing additive effects for women who are under estrogen replacement therapy or taking the oral contraceptive pill(10).

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Sources
(1) "Effect of protein-xanthophylls (PX) concentrate of alfalfa supplementation on physico-chemical properties of turkey breast and thigh muscles during ageing" by Karwowska M, Stadnik J, Dolatowski ZJ, Grela ER., posted in PubMed
(2) "Alfalfa seeds: effects on cholesterol metabolism." Posted in PubMed
(3) "Alfalfa seeds lower low density lipoprotein cholesterol and apolipoprotein B concentrations in patients with type II hyperlipoproteinemia", posted in PubMed
(4) " The ethyl acetate extract of alfalfa sprout ameliorates disease severity ofautoimmune-prone MRL-lpr/lpr mice" by Hong YH, Huang CJ, Wang SC, Lin BF., posted in PubMed
(5) "Ethyl acetate extracts of alfalfa (Medicago sativa L.) sprouts inhibit lipopolysaccharide-induced inflammation in vitro and in vivo" by Hong YH, Chao WW, Chen ML, Lin BF., posted in PubMed
(6) "Dietary amino acid-induced systemic lupus erythematosus" by Montanaro A, Bardana EJ Jr., posted in PubMed
(7) "Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms" byLiu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL., posted inPubMed
(8) "Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult" by Bora KS, Sharma A., posted in PubMed

(9) Interaction Between Dietary Vitamin K Intake and Anticoagulation by Vitamin K Antagonists: Is It Really True? A Systematic Review by Francesco Violi, MD, Gregory YH Lip, MD, Pasquale Pignatelli, MD, and Daniele Pastori, MD, Monitoring Editor: Xiwen Cheng(PMC)

(10) Alfalfa(Rexall Pharma Plus)

Thursday 5 April 2018

Aloe Vera 11 Impressive Health Benefits and 4 Ugly Adverse Effects, You Probably Want to Know, According to PubMed

Kyle J. Norton

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan.

The herbal medicine has become very popular for commercial cultivation due to its health benefits.

Aloe vera has been used in herbal medicine in treatment of many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

A. Health benefits of Aloe Vera Based on Medical Literature
1. Cancer
Eventhough Aloe Vera is not one of the herb used in herbal medicine in treating cancer, but according to some studies, Aloe Vera has a property of inhibiting the growth of cancer and apoptosis, according to the study of "Medicinal plants used as antitumor agents in Brazil: an ethnobotanical approach" by de Melo JG, Santos AG, de Amorim EL, do Nascimento SC, de Albuquerque UP., posted in PubMed (1), researchers found that our analysis included papers published between 1980 and 2008. A total of 84 medicinal plant species were reported to be used for cancer and tumor prevention or treatment; 69.05% of these were cited as being used for the treatment of tumors and cancer in general and 30.95% for specific tumors or cancers. The plants that were cited at a higher frequency were Aloe vera, Euphorbia tirucalli, and Tabebuia impetiginosa.

2. Antiaging (Wrinkle Prevention)
There are many products of Aloe Vera sold commercially as an natural anti wrinkle magic in health perspective, is Aloe Vera really has that property? according to the study of "Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo" by Cho S, Lee S, Lee MJ, Lee DH, Won CH, Kim SM, Chung JH., posted in PubMed(2), researchers filed the conclusion that Aloe gel significantly improves wrinkles and elasticity in photoaged human skin, with an increase in collagen production in the photoprotected skin and a decrease in the collagen-degrading MMP-1 gene expression. However, no dose-response relationship was found between the low-dose and high-dose groups.

3. Laxation
Aloe Vera beside enhances motility of the intestines, but also increases fecal volume and normalizes body weight, that can reduce the risk of constipation, according to the study of "The effect of Aloe ferox Mill. in the treatment of loperamide-induced constipation in Wistar rats" by Wintola OA, Sunmonu TO, Afolayan AJ., posted in PubMed(3)

4. Skin
Aloe Vesa has been used as skin care as a cosmetic and pharmaceutical ingredients, according to the study of " Innovations in natural ingredients and their use in skin care' by Fowler JF Jr, Woolery-Lloyd H, Waldorf H, Saini R., posted in PubMed(4), researchers wrote that Certain ingredients, such as colloidal oatmeal and aloe vera, have been identified as beneficial in the treatment of psoriasis and atopic dermatitis, respectively, due to their anti-inflammatory properties.

5. Wound
Aloe Vera has been used in herbal medicine beside improves wound healing as a result of the presence of mannose-6-phosphate, according to the study of "Anti-inflammatory and wound healing activity of a growth substance in Aloe vera" by Davis RH, Donato JJ, Hartman GM, Haas RC., posted in PubMed(5), but also enhances burn healing, according to the study of "Effect of aloe cream versus silver sulfadiazine for healing burn wounds in rats" by Hosseinimehr SJ, Khorasani G, Azadbakht M, Zamani P, Ghasemi M, Ahmadi A., posted in PubMed(6), researchers concluded that this study showed aloe cream to significantly increase reepithelialization in burn wounds as compared with silver sulfadiazine.

6. Diabetes
Aloe Vesa helps to treat diabetes by controlling the blood glucose, reducing hepatic transaminases plasma and tissue (liver and kidney) cholesterol, triglycerides, free fatty acids and phospholipids and improvement in plasma insulin levels, according to the study of "Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes" by Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S., posted in PubMed(7)

7. Immune system
Aloe Vera enhances the immune system by enhancing the immunological parameters in cellular immune response and phagocytosis, according to the study of "Modulation of Immune Response of BALB/Mice Bearing Lymphoma L5178Y Treated with Bitter Yellow Juice of Aloe vera (L) in vivo" by Oronzo-Barocio A, Zaitseva G, Chavez-Anaya A, Arceta-Gonzalez VI, Puebla-Perez AM, Alfaro-Bustamante F, Zimina IV, Arion VY., posted in PubMed(8)

8. Human papillomavirus (HPV)
The herb beside contains a antibactera and fungal properties, it also enhance the immune system infifgting against Human papillomavirus, according tothe study of "A novel polyherbal microbicide with inhibitory effect on bacterial, fungal and viral genital pathogens"Talwar GP, Dar SA, Rai MK, Reddy KV, Mitra D, Kulkarni SV, Doncel GF, Buck CB, Schiller JT, Muralidhar S, Bala M, Agrawal SS, Bansal K, Verma JK., posted in PubMed(9)

9. Antioxidants
Aloe Vera also is popular used in treating infection and inflamation as a result of its antioxidant property. according to the study of " In Vitro Antimicrobial and Antioxidant Activities of Anthrone and Chromone from the Latex of Aloe harlana Reynolds" by Asamenew G, Bisrat D, Mazumder A, Asres K., posted in PuibMed(10)

10. Weight loss
Since aloe Vera contains high amounts of collagen fiber, it can use as a weight loss program as more energy are needed for the digestive process, according to the article of "Collegen" posted in Wikipedia in the "use" section(11)

11. Low levels of cholesterol
Aloe Vera can help to reduce the levels of total cholesterol, LDL-cholesterol, VLDL-cholesterol and triglycerides in blood serum, thus reducing the risk of cardivascular disease, according to the study of "Lipid lowering activity of hydrosoluble chitosan and association with Aloe vera L. and Brassica olearaceae" L' by Geremias R, Pedrosa RC, Locatelli C, de Fávere VT, Coury-Pedrosa R, Laranjeira MC., posted in PubMed(12)

B. Side effects
1. Hepatitis
Some researchers concerned that the over use of oral aloe vera may contribute to acute hepatitis, according to the study of "Oral aloe vera-induced hepatitis" by Bottenberg MM, Wall GC, Harvey RL, Habib S., posted in PubMed(13)
2. Diarrhea, caused by the laxative effect of oral use of Aloe Vera
3. Oral use of Aloe Vera may cause abdominal cramps and pain
4. It may cause rheumatoid arthritis symptoms as a result of collagen in the plant, according to the study of "Oral type II collagen in the treatment of rheumatoid arthritis. A six-month double blind placebo-controlled study" by Cazzola M, Antivalle M, Sarzi-Puttini P, Dell'Acqua D, Panni B, Caruso I., posted in PubMed(14)

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

References
(1) http://www.ncbi.nlm.nih.gov/pubmed/21528006
(2) http://www.ncbi.nlm.nih.gov/pubmed/20548848
(3) http://www.ncbi.nlm.nih.gov/pubmed/20723249
(4) http://www.ncbi.nlm.nih.gov/pubmed/20626172
(5) http://www.ncbi.nlm.nih.gov/pubmed/8169808
(6) http://www.ncbi.nlm.nih.gov/pubmed/20361881
(7) http://www.ncbi.nlm.nih.gov/pubmed/16487267
(8) http://www.ncbi.nlm.nih.gov/pubmed/12687115
(9) http://www.ncbi.nlm.nih.gov/pubmed/18571386
(10) http://www.ncbi.nlm.nih.gov/pubmed/21452374
(11) http://en.wikipedia.org/wiki/Collagen
(12) http://www.ncbi.nlm.nih.gov/pubmed/16557611
(13) http://www.ncbi.nlm.nih.gov/pubmed/17726067
(14) http://www.ncbi.nlm.nih.gov/pubmed?term=Oral%20type%20II%20collagen%20in%20the%20treatment%20of%20rheumatoid%20arthritis.%20A%20six-month%20double%20blind%20placebo-controlled%20study.%20

Wednesday 4 April 2018

Eating Healthy, Replace Sugar with This Ingredient to Enjoy 22 Medical Benefits, According to PubMed

Kyle J. Norton.

Consumption of added sugars has a strong implication in increased risk of a variety of chronic diseases including obesity, cardiovascular disease, diabetes and non-alcoholic fatty liver disease (NAFLD) as well as cognitive decline and even some cancers(3).

To replace 1 cup of white sugar you can substitute it for 3/4 cup honey.

According to the the Universtà Politecnica delle Marche,

* Honey positively affects risk factors for cardiovascular diseases by inhibiting inflammation[1], improving endothelial function[2], as well as the plasma lipid profile[3], and increasing low-density lipoprotein resistance to oxidation[4](4).

* Honey also displays an important antitumoral capacity[5], where polyphenols again are considered responsible for its complementary and overlapping mechanisms of chemopreventive activity in multistage carcinogenesis, by inhibiting mutagenesis or inducing apoptosis(4).

*Moreover, honey positively modulates the glycemic response by reducing blood glucose[6], serum fructosamine[7] or glycosylated hemoglobin[8] concentrations and exerts antibacterial properties caused by its consistent amount of hydrogen peroxide[9] and non-peroxide[10] factors as flavonoids, methylglyoxal and defensin-1 peptide"(4).

Here are health benefits of honey

The rich golden liquid is the miraculous product made by bees using nectar from flowers. It is considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Nutrients
1. Carbohydrates
2. Sugars
3. Protein
4. Water
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (Vitamin B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Iron
13. Magnesium
14. Phosphorus
15. Potassium
16. Sodium
17. Zinc

A. health benefits according to studies
1. Acute cough in children[11]
In the investigation of the effectiveness of honey for acute cough in children in ambulatory settings found that Dextromethorphan and honeydid not differ significantly on cough frequency (MD -0.49; 95% CI -1.15 to 0.17); cough severity (MD -0.50; 95% CI -1.28 to 0.29), bothersome cough(MD -0.29; 95% CI -1.14 to 0.56) and sleep quality of the children (MD -0.70; 95% CI -1.57 to 0.17) or their parents (MD -0.34; 95% CI -1.24 to 0.55) and concluded that we found insufficient evidence to advise for or against the use of honey for acute cough in children, according to "Honeyfor acute cough in children" by Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE.(a)

2. Wound healing[12]
In the assessment of Potential role of honeyon wound healing found that honey may improve healing times in mild to moderate superficial and partial thickness burns compared with some conventional dressings. Honey dressings as an adjuvant to compression do not significantly increase leg ulcer healing at 12 weeks.

There is insufficient evidence to guide clinical practice in other areas. according to "Honey as a topical treatment for wounds" by Jull AB, Rodgers A, Walker N.(b)

3. Antiproliferative effect[13]
In the identification of honey and its effect on keloid fibroblasts found that the methanolic honey extraction has an antiproliferative effect on keloid fibroblasts and a range of volatile compounds has been identified from Tualang honey.

The antiproliferative effect of keloid fibroblasts towards Tualang honey may involve cell signaling pathway.

Identifying other volatile compounds from different organic solvents should be carried out in future, according to "Antiproliferative effect of methanolic extraction of tualang honey on human keloid fibroblasts" by Nurul Syazana MS, Halim AS, Gan SH, Shamsuddin S.(c)

4. Antibacterial properties[14]
In the classification of Honey possesses therapeutic potential on antibiotic resistance of bacteria
found that Tualang honey exhibited variable activities against different microorganisms, but they were within the same range as those for manuka honey. This result suggests that tualang honey could potentially be used as an alternative therapeutic agent against certain microorganisms, particularly A. baumannii and S. maltophilia, according to "The antibacterial properties of Malaysian tualang honey against woundand enteric microorganisms in comparison to manuka honey" by Tan HT, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, Kirnpal-Kaur B.(d)

5. Anti-inflammatory and antioxidant effects[15]
In assessment of Tualang honey and its anti-inflammatory and antioxidant effects found that Tualang honey has almost the equal effects when compared with the conventional treatment in treating alkali injury on rabbit's eye. Future research with more number of rabbits and control group is warranted to explore the anti-inflammatory and antioxidant effects of Tualang honey, according to "Anti-inflammatory and antioxidant effects of Tualang honey in alkali injury on the eyes of rabbits: experimental animal study" by Bashkaran K, Zunaina E, Bakiah S, Sulaiman SA, Sirajudeen K, Naik V.(e)

B. Health benefits according to concentration
Honey contains high amount of glucose and fructose that are simple sugar (monosaccharide) played an important role to enhance energy production in carbohydrate metabolism, as they
are absorbed by the body quickly through insulin and potassium[16].

C. Other health benefits
1. Antiseptic[17] and antibacterial properties[18]
Recently research study that honey have the antiseptic and antibacterial properties as it increases the immune system in fighting the forming of free radicals causes of inflammation and infection causes of infection due to enzyme glucose oxidase, according to the study of `Antibacterialproperties of tualang honey and its effect in burn wound management: a comparative study`by Nasir NA, Halim AS, Singh KK, Dorai AA, Haneef MN., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20576085), researchers found that Tualang honey has a bactericidal as well as bacteriostatic effect. It is useful as a dressing, as it is easier to apply and is less sticky compared to Manuka honey. However, for Gram positive bacteria, tualang honey is not as effective as usual care products such as silver-based dressing or medical grade honey dressing.

2. Diabetes chronic wound[19]
External used is proven to be effective for treating diabetes chronic wound that antibiotic can not be used, according to the study of `Safety and efficacy of a new honey ointment on diabetic foot ulcers: a prospective pilot study`by Abdelatif M, Yakoot M, Etmaan M., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/18376651, researchers indicated that Ninety-six per cent of the patients in groups 1 and 2 responded well, with a complete cure, defined as'complete closure of the ulcer without signs of underlying bone infection' by the end of week 9 and for the duration of the six-month follow-up period. All of the ulcers in group 1 healed, as did 92% of those in group 2. All patients in group 3 healed following surgical excision, debridement of necrotic tissue and conservative treatment with PEDYPHAR ointment.

3. Phosphorus[20]
Beside providing strength to bones and teeth by working together with calcium according to the study of `[The effect of one year therapy with recombinant human growth hormone (rhGH) on growth velocity, calcium-phosphorus metabolism, bone mineral density and changes in body composition in children with growth hormone deficiency (GHD)].[Article in Polish]`by Zak T, Basiak A, Zubkiewicz-Kucharska A, Noczyńska A., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/20529605), it also works with riboflavin and niacin to improve the digestive system in absorbing vital nutrients.

4. Iron[21] and iron deficiency anemia[22]
Iron is essential for the production of red blood cells and carrying life-giving oxygen to human cells. Deficiency of iron causes anemia, anemia of chronic disease, cough, anemia in pregnancy, etc., leading to reducing blood flow to the reproductive organ according to the study of `The effects of iron deficiency on estradiol-induced suppression of erythropoietin induction in rats: implications of pregnancy-related anemia` by Horiguchi H, Oguma E, Kayama F., posted in PubMed (http://www.ncbi.nlm.nih.gov/pubmed/15784734)

Side effects

1. Because of the presence of botulinum endospores, children under one year of age should not be given honey
2. Honey may be poison if produced from the flowers of oleanders, rhododendrons, mountain laurels, sheep laurel, and azaleas etc.
3. It may contain traces of heavy metals, pesticides, etc.

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Sources

(1) HOW TO SUBSTITUTE SUGAR IN YOUR BAKING & FREE SUBSTITUTES CHART! By Gemma Stafford .

(2) Comparison of the enhancement of plasma glucose levels in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats by oral administration of sucrose or maple syrup by Nagai N1, Ito Y, Taga A.(PubMed)
(3) Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding by James M. Rippe1,2,* and Theodore J. Angelopoulos3(PubMed)
(4) Honey as a source of dietary antioxidants: structures, bioavailability and evidence of protective effects against human chronic diseases by Alvarez-Suarez JM1, Giampieri F, Battino M.(PubMed)
(a) http://www.ncbi.nlm.nih.gov/pubmed/20091616
(b) http://www.ncbi.nlm.nih.gov/pubmed/22050652
(c) http://www.ncbi.nlm.nih.gov/pubmed/21943200
(d) http://www.ncbi.nlm.nih.gov/pubmed/19754926
(e) http://www.ncbi.nlm.nih.gov/pubmed/21982267