Herbal Therapy: Green Tea and its Bioactive Polyphenol Epigallocatechin 3-gallate (EGCG) in Alleviated Symptoms, Reduced Risk, Progression and Treatment of Arthritis

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of arthritis, some scientists suggested.

Arthritis is a chronic condition characterized by painful inflammation and stiffness of the joints.

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

According to statistic, arthritis is the common autoimmune disorder affected over 50 millions world wide.

According to the College of Pharmacy, green tea epigallocatechin 3-gallate (EGCG) in preclinical studies displayed a significant effect in treatment of arthritic disease.

In vitro, application of green tea extract EGCG demonstrated activities in cartilage-preserving and chondroprotective action through reduced expression of proinflammatory IL-1β, TNFα, and IL-6
and modulated extracellular matrix (ECM) turnover induced changes of the biomechanical environment of chondrocytes and accelerate the degradation of cartilage as well driving the progression of the disease in the presence of inflammation.

Normal extracellular matrix (ECM) is a composed collagen type II with function to provide tensile support for the tissue. 

Further analysis in expression of proinflamatory factors researchers found that the over expression of proinflammatory cytokines IL-1 and IL-6 were associated correlatively in knee joints in arthritis and inhibition of IL-1 snd IL-6  by green tea EGCG IL-1 showed to reduce joint damage.

Some researchers also suggested that Interleukin 1 (IL-1) is a crucial mediator of the inflammatory response, playing an important part in the body's natural responses and the development of pathological conditions leading to chronic inflammation.

In expression of tumor necrosis factor (TNF), tumor necrosis factor alpha(TNFα, cachexin, or cachectin), application of green tea inhibited the levels of TNFα in induction of synovial fibroblast cytotoxicity.

Interestingly, in the study to evaluate the possible effects of the administration of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, researchers indicated that green tea daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days displays a strong effect in decreased symptoms of arthritis by ameliorated diminutions in protein and lipid damage in liver, brain and plasma, through antioxidant effect in reduced levels of ROS in stimulated free radical chain reaction to initiate production of pro inflammatory cytokines to precipitate chronic diseases.

Rats treated with green tea EGCG also showed a significant improvement in restored natural antioxidant glutathione (GSH) and protein thiol levels produced by the body, by exhibiting the activities of the antioxidant enzymes.

Moreover, green tea injection also normalized the activity of glucose 6-phosphate dehydrogenase, which is increased in the liver of arthritic patients and considered as a risk factor for the development of arthritis. Increased activity glucose 6-phosphate dehydrogenase was associated to reactive oxygen species (ROS) generated in oxidative metabolism in inflicted damage on all classes of macromolecules.

Additional differentiation of green tea EGCG immunomodulatory effects and mechanisms on experimental arthritis induced by collagen-induced arthritis (CIA) in mice in compared to control received phosphate buffered saline (PBS), researchers found that application of green tea EGCG at dose of 10 mg/kg demonstrated a strong effect in ameliorated clinical symptoms and reduced histological scores in arthritic mice, through modulated the immune activity by induced over expression of the Nrf-2 antioxidant pathway, a major mechanism in the cellular defense against oxidative or electrophilic stress through detoxication and elimination.

EGCG also ameliorated experimental arthritis in mice by eliciting indoleamine-2,3-dioxygenase (IDO) through inhibition of pro-inflammatory cytokine interferon-gamma, astrocytes and microglia in facilitated production of dendritic cells (DCs) in activation of the immune system to attack  the dendritic cell located on surface on the joint tissue.

Application of the EGCG also increased frequencies of T regs with a dominant role in suppression of autoimmune pathology.

Some researchers suggested that increased Treg number and/or function in model systems may have a significant effect in both prevented and reversed arthritis disease.

Taken together, green tea with abundant bioactive polyphenol epigallocatechin 3-gallate (EGCG) may be considered as a functional food for alleviated symptoms, reduced risk, and progression and treatment of arthritis.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM.(PubMed)
(2) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S1,3, Kwon SR1,4, Vanarsa K1,3, Kim HY4, Davis LS#1, Mohan C(PubMed)
(3) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)
(4) Is IL-1 a good therapeutic target in the treatment of arthritis? by Burger D1, Dayer JM, Palmer G, Gabay C.(PubMed)

Alternative Therapy: Yoga In Improved Symptoms and Quality of Life in Asthma Patients

Kyle J. Norton 

Yoga Therapy may be used as an integrated form of exercise to improve symptoms and  quality of life in patients with asthma, some scientists suggested.

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.

Yoga, the ancient technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement and gesture..... has been well known for people in Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a randomized controlled trial of yoga effect in patients of asthma through searching the database of MEDLINE/PubMed, Scopus, the Cochrane Central Register of Controlled Trials, PsycINFO, CAM-Quest, CAMbase, and IndMED up to January 2014, researchers found that yoga intervention improved
* Asthma control, asthma symptoms
* Health quality of life
* Peak expiratory flow rate and ratio of forced expiatory volume in 1 second to forced vital capacity and Yoga was not associated with serious adverse events.

After adjusting to other co founders, Dr. Cramer H, the led author said, "(even with all information collected) Yoga.......can be considered an ancillary intervention or an alternative to breathing exercises for asthma patients interested in complementary interventions".

Truly, yoga mindfulness intervention have a significantly reduced stress implication on central nervous system in production of stress hormones in activated hormone prostaglandin H2 to precipitated muscle constriction of the lung, ameliorated risk of  tightening of the smooth muscle around the airways in initiated shadowed, breathing, fast, and difficult.

Yoga relaxation and meditation also improved the production of natural production of antioxidant found in the body in reduced the oxidative stress in decreased enzymes nitric oxide synthases(NOSs) in catalyed the production of nitric oxide (NO) from L-arginine in modulated vascular tone, thus promoting lung blood vessel relaxation in attenuated risk of asthmatic attacks.

Furthermore, yoga practice also balanced and connected the mind and body by bringing back the natural state of individual consciousness in the presence, while letting them go or dealing them with a profound and positive way, thus stimulated a natural reaction in enhanced lung function by sending more blood to the lung region in reduced risk of hyperinflation of the lungs, increased work of breathing and improved lung forced respiration volumes and flow rates.

Moreover, yoga postures and slow breathing also improved lung function by increased blood flow to the organ and decreased sympathetic reactivity and relaxed voluntary inspiratory and expiratory muscles, thus ameliorated risk of CO2 accumulation in initiated asthma attacks.

The result of analysis indicated a strong impact of yoga intervention in improved quality of life of asthma patients through engaging in physical and social activity without worrying of fear of sudden asthma attack, psychologically.

The differentiation of above were supported by, the Christian Medical College and Hospital  study of 120 non-smoking male and female patients of asthma in the age group of 17-50 years randomized assigned into two groups i.e. Group A (Yoga group) and Group B (control group).

According to the study, after 8 weeks of yoga lessons, yoga group showed
* A statistically significant improvement in "symptoms", "activities" and "environmental" domains, according to the Asthma Quality of Life Questionnaire (AQLQ) at week 8
* A reduction in daily number and severity of attacks and
*  A decrease the use of medicine gradually during week 4 and 8 in compared to the baseline

And,  the investigation of yoga efficacy of one month in-patient naturopathy and yoga programme of a total of 159 patients with bronchial asthma as integrated form of exercise.

According to the research, yoga intervention expressed a significant increase of the
* Forced Vital Capacity and Forced Expiratory Volume from the date of admission up to 6th month,
* Maximum Voluntary Ventilation from admission till the date of discharge and
* Peak Expiratory Flow Rate  from admission till the 36th month of follow-up

With all findings, researchers suggested that Yoga participated may be used as secondary therapy in conjucntion with standard pharmacological treatment in significantly improved symptoms and quality of life in patients with bronchial asthma.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Yoga for asthma: a systematic review and meta-analysis by Cramer H1, Posadzki P2, Dobos G3, Langhorst J3.(PubMed)
(2) Assessment of the quality of life in patients with bronchial asthma, before and after yoga: a randomised trial by Sodhi C1, Singh S, Bery A.(PubMed)
(3) Efficacy of naturopathy and yoga in bronchial asthma by Rao YC, Kadam A, Jagannathan A, Babina N, Rao R, Nagendra HR(PubMed).

Herbal Therapy: Green Tea and Its Bioactive Polyphenols in Reduced Alpha1-Antitrypsin (AAT) Deficiency in Induction of Fibromyalgia

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced onset. progression and treatment of Alpha1-Antitrypsin (AAT) deficiency in induced fibromyalgia, some scientists suggested.

Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and Western world.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in US alone.

Serum of alpha1-Antitrypsin (AAT) impregnated in most body tissues circulates in our body in high concentrations with function as a broad anti-inflammatory spectrum in inhibition of enzymes of inflammatory cells, especially neutrophil elastase.

In the study of the effect of serum of alpha1-Antitrypsin (AAT) and risk of fibromyalgia (FM), researchers at the Hospital Valle del Nalón found that deficiency of AAT has been found in numbers of patients with fibromyalgia (FM) with severe hereditary.

Functional magnetic resonance imaging of these patients revealed a significant greater activity in pain sensitive areas of the brain in response to cutaneous stimuli, which may be another evidence for a physiological explanation for FM pain.

Furthermore, patients with FM also were found to consist an abnormal profiles of inflammation markers in biopsies analysis.

The results suggested that these patients may have an imbalance levels of pro inflammatory and anti-inflammatory substances, in the soft body tissues caused by alpha1-Antitrypsin (AAT) deficiency.

Due to surprising findings, Dr. Blanco LE, the lead author, after taking into account of other confounders, said, "identification of genetic, familial, and environmental risk factors suspected to participate in the FM syndrome development (may be necessary) to determine the gene frequency of AAT deficiency alleles in FM patients".

Green tea, bioactive polyphenols EGCG, according to the Dr Helieh S in animal model induced by alpha1-Antitrypsin (AAT) (α1-antitrypsin) deficiency exerted a significant anti inflammatory effect in inhibited the PI3K/Akt signalling pathway with function in activated proinflammaory factors through the innate immune response involved in pathogen killing, antigen processing and immune cell survival.

Moreover, green tea EGCG application also enhanced antioxidant activity not only through its antioxidant profiles, but also stimulated production of the body natural antioxidants in reduced inflammatory response through nitric oxide (NO) and inducible nitric oxide synthase (iNOS) expression, observed by Griess reagent and western blotting.

These results indicated that green tea EGCG may have a profound effect in reduced serum alpha1-Antitrypsin (AAT)  deficiency in initiated the onset of fibromyalgia 

The above differentiations were supported by the review of Chronic Inflammatory Diseases and Green Tea Polyphenol, by Dr. Helieh S. Oz at the University of Kentucky Medical Center.

According to the authors, green tea polyphenols are potent antioxidants with important roles in regulating vital signaling pathways in activated inflammatory responses by attenuated nuclear factor (NF)-kappaB IKK, NF-κB in facilitated innate- and adaptive-immune responses, cell death and inflammation and cytokines like TNFα, inflammatory markers and cyclooxygenase-2 in elevated symptoms of inflammation and pain.

Dr. Helieh S. in summary said, "green tea polyphenols (GrTPs) are potent antioxidants with important roles in regulating vital signaling pathways" and "these comprise transcription nuclear factor-kappa B mediated I kappa B kinase complex pathways, programmed cell death pathways like caspases and B-cell lymphoma-2 (through regulating the cytochrome c release from the mitochondria) and intervention with the surge of inflammatory markers like cytokines and production of cyclooxygenase-2"".

Taken together, green tea and its bioactive polyphenols may be considered as a function food in ameliorated serum alpha1-Antitrypsin (AAT) deficiency effect in initiated the onset of fibromyalgia.  However, intake of green tea supplement should be taken with extreme care due to recent medical reports of acute liver toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) alpha1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia by Blanco LE1, de Serres FJ, Fernańdez-Bustillo E, Kassam DA, Arbesú D, Rodríguez C, Torre JC.(PubMed)
(3)  Chronic Inflammatory Diseases and Green Tea Polyphenols by Helieh S. Oz(PubMed Central Canada)

Herbal Therapy: Green Tea and its Bioactive epigallocatechin 3-gallate (EGCG) in Attenuated Risk, progression of Fibromyalgia Caused by Inflammatory Rheumatic Disorders

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced onset, progression and treatment of inflammatory rheumatic disorders induced fibromyalgia, some scientists suggested.

Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in US alone.

Inflammatory rheumatic disorder is condition of autoimmune diseases caused inflammatory connective tissues, joint and vessels of the body, including rheumatoid arthritis, systemic lupus erythematosus and vasculitis.

According to the Cairo University, as many as 15-30% of patients with classic inflammatory rheumatic disorders also have a co-morbid fibromyalgia syndrome (FMS) incompared to the rate of only 2% of the prevalence of FMS in the general population (2%).

These results suggested that rheumatological syndromes has a strong implication in the development of fibromyalgia syndrome (FMS) in compared to other initiators such as stress.

Therefore, patients with chronic rheumatic diseases are capable of triggering condition of  fibromyalgia syndrome (FMS).

Due to the highly correlated rheumatologic disease and FMS component, researchers postulated "Considerations of the FMS component in the management of rheumatologic diseases increase the likelihood of the success of the treatment" and "(prevented) FMS in misdiagnosed as an autoimmune disorder"

In the study of the effect of green tea's active ingredient, epigallocatechin 3-gallate (EGCG) in risk of inflammatory rheumatic disorders in collagen-induced arthritis (CIA) in mice, researchers found that application of green tea demonstrates a substantially marked inhibition of the inflammatory mediators cyclooxygenase (COX) -2 in converting arachidonic acid in stimulated production of proinflammatory cytokine prostaglandin H2, in catalyzation of symptoms of inflammation in the muscles.

Furthermore, green tea EGCG oral ingestion also inhibited levels of interferon gamma in precipitated inflammation by modulating T-cells and natural killer cells activated by antigens, mitogens or alloantigens to the site of infection.

Tumor necrosis factor alpha (TNFα) involved in systemic inflammation, one of the cytokines that make up the acute phase reaction in mice was also inhibited by injection of green tea EGCG.

These result suggested that green tea ameliorated symptoms expression of inflammatory rheumatic disorders, through attenuating production pro inflammatory factors without reducing the healing progression of injure tissue.

The above differentiation were supported by the study of  green tea extract GTE in modestly ameliorated rat adjuvant-induced arthritis.

According to researchers, a daily per oral administration of GTE (200 mg/kg) reduced expression of RA through reduced levels of MCP-1/CCL2 in expression (which can also be treated by biological agents, such as antibodies and inhibitory peptides) of a variety of diseases characterized by mononuclear cell infiltration involved substantial biological and genetic evidence,  including RA.
 and GROα/CXCL1 in the recruitment of inflammatory cells in the wound healing process after injury in angiogenesis and in formation of granulation tissue of wounds.

Additionally, application of green tea beside attenuated the expression of proinflammatory factors, its also exhibited the production of chemokine receptors CCR-1, CCR-2, CCR-5 in reduced direct communication between the innate and adaptive immune responses in initiated the development of inflammatory responses. through inactivation of leukocytes in inflamed tissues in contribution to the pathogenesis of inflammatory and autoimmune diseases.

And CXCR1 receptor in binding to IL-8 in reduced expression some infallmatory cytokines in initiated inflammation such as epidermal growth factor (EGF) and tumor necrosis factor-α (TNF-α).

Some researchers suggested that application of green tea extract may also reduce the symptoms of arthritis through expression of  IL-6 levels, as increased levels of Il-6 was associated to the presence and progression of rheumatoid arthritis (RA) found in conventional clinical and laboratory indices and MMP-2 activity in activated immune inflammatory response through inducing production of pro inflammatory factors.

Taken together, green tea and its bioactive compound such as EGCG may have a profound and theurapeutic effect in reduced the onset, progression and treatment of fibromyalgia induced by inflammatory rheumatic disorders through modulating the production of pro and anti inflammatory proteins. However, intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Fibromyalgia and Rheumatic Diseases by Gheita TA*, El-Rabbat SM and Mahmoud NK(Open Access)
(2) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Salahuddin Ahmed(PMC)

Herbal Therapy: Green Tea And Its Bioactive Polyphenols in Reduced Risk, Progression of Fibromyalgia Caused by Sleep Disturbance

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced onset, progression and treatment of  fibromyalgia caused by sleep disturbance, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain affecting over 10 million (3.6% of the population) people in US alone.

In the study of sleep disturbance causable fibromyalgia Dr. Choy EH suggested that patients with fibromyalgia demonstrated a reduced short-wave sleep and abnormal α-rhythms, suggestive of wakefulness during non-REM (rapid eye movement) sleep in compared to the healthy individuals according observation of polysomnography.

Further more, in healthy participants, the study indicated that sleep deprivation can also cause fibromyalgia like symptoms such as myalgia, tenderness and fatigue and suggested that sleep dysfunction might be not only a consequence of pain.

These results showed a strong correlated conditions of sleep disturbance and initiation of chronic fibromyalgia if sleep disorders are left untreated for a prolonged period of time.

Moreover, according to the presentation, long time effect of sleep disturbance may influences alter the pathophysiology of the central nervous system in abnormal pain processing and central sensitization, according to observation of the neuroimaging of patients with fibromyalgia neural activation in compared to lower pressure-pain threshold in healthy age-matched and gender-matched individuals.

After taking into account to other con founders, researchers said, " improving sleep quality can reduce pain and fatigue, further supporting the hypothesis that sleep dysfunction is a pathogenic stimulus of fibromyalgia".

Green tea, bioactive polyphenols (-)-Epigallocatechin gallate (EGCG) in the evaluation of the the chick brain under an acute stressful condition in facilitated sleep disturbance, researchers found that EGCG attenuates stress behavior with special reference to gamma-aminobutyric acid (GABA), a neurotransmitter with function in sending chemical messages through the brain and the nervous system, and involving in regulating communication between brain cells in stress environment.

Deficiency of is associated to many nervous conditions, including depression, anxiety, and sleep disorders.

Application of EGCG of doses of 50, 100 and 200 microg, intracerebroventricularly exerted a profound effect in suppressed the vocalization which normally occurs during social separation stress.

This illustration truly suggested that EGCG reduced the time spent in active wakefulness and induced sleep-like behavior in a dose-dependent manner.

Further more, under influence and presence of the GABAA receptor antagonist picrotoxin but not by the GABAB receptor antagonist CGP 54626 (3-N-(1-(3,4-dichlorophenyl)ethylamino)-2-hydroxypropyl cyclohexylmethyl phosphinic acid hydrochloride), a antidote in poisoning by CNS depressants, the effect of green tea EGCG is significantly decrease in attenuated the production of hormone corticosterone release under social separation stress.

These interaction opinionated that EGCG inducted sedation and hypnosis in reduced stress hormone production in precipitated sleep distance probably though GABAA receptors in moderated an acute stress response.

Some researchers suggested that green tea improved symptoms of fibromyalgia by normalizing the levels of GABA (gamma-aminobutyric acid) when came under stress,  may have a therapeutic effect in reduced anxiety by relaxing the muscles and the brain. through increased production of dopamines, serotonin, and alpha waves within the brain in orchestrated the sleep pattern.

These improvements were associated to the interaction of the brain with chemical compounds found in green tea Caffeine and L-theanine, suggested by the author.

Taken together, the information findings suggested that green tea and its bioactive polyphenols EGCG and L-theanine may be considered as a functional food for reduced risk, progression and treatment of fibromyalgia caused by sleep disorder. However, intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The role of sleep in pain and fibromyalgia by Choy EH(PubMed)
(2) (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain by Adachi N1, Tomonaga S, Tachibana T, Denbow DM, Furuse M.(research gate)
(3) Green Tea Health Benefits To Get You Drinking Healthy! by Abby Hannaford

Herbal Therapy: Green Tea in Ameliorated Onset, Progression and Treatment of Juvenile Arthritis

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced prevalence, progression and treatment of juvenile arthritis, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.

According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.

In the investigation of the effect of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, a model for human rheumatoid arthritis with daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days, researchers at the State University of Maringá, found that treatment group expessed a significant activity in reduced the protein and lipid damage in liver, brain and plasma, caused by ROS expression in induction of oxidation which have been found to associated to the progression of arthritis.

Injection of green tea extract also enhanced the over expression of antioxidant defenses, found in low levels in patients with arthritis through restoration of the glutathione (GSH) with important function in preventing damage to important cellular components caused by reactive oxygen species and protein thiol levels in reduced cellular oxidation through chelative and detoxified activities and improved the natural antioxidant enzymes, produced by the body.

Further more, green tea extract also inhibited the levels of glucose 6-phosphate dehydrogenase, which is increased  in the liver, one of major risk factor for the development of arthritis.

These results suggested that application of green tea exerted a significantly profound effect in the liver and brain of patients suffering from rheumatoid arthritis through reduced over expression of oxidative stress in precipitated injury to lipids and proteins.

Some researchers suggested that by modifying the metabolic function in lipid and protein, green tea extract exhibited a strong protective effect in reduced the symptoms and progression of arthritis.

According to the study of University of Health System of green tea effect in patient with rheumatoid
arthritis, injection of green tea extract demonstrated a therapeutic effect in patients synovial fibroblast
of the lining of the tissue which surround the capsule of the joint by inhibited the production of IL-1B, a prototypic proinflammatory cytokines in response to acute and chronic inflammation. Over expression of IL-1B is associated in contribution of joint damage.

Interestingly, in the study of adolescent male Wistar rats 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet randomly assigned to 12 to each group, as positive control received without Cd, Pb and teas, a negative control group received Cd and Pb, and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT), researchers indicated that application of tea significant inhibits the decreased levels of the geometric(shape) and densitometric(density) parameters and total thickness of articular cartilage caused by Cd and Pb in compared to the negative control group.

Tea injection group also displayed a huge improvement in mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type.

Due to limitation of the study, Dr. Tomaszewska E, the lead researcher said, " It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action".

More importantly, in the examine some major factors in contributed to the juvenile arthritis, green tea rich in catechins (Healthya green tea) in animal study restored these biomarkers of cytokine genes (IL-1A, IL-2, IFN-alpha, FGF-alpha, TNF-alpha) to near normal levels, thus preventing or attenuating the development of a certain type of inflammatory arthritis.

Taken together, green tea and its bioactive polyphenols may be considered as a functional food for reduced early onset, progression and combined with standard therapy for treatment of juvenile and adult arthritis. However, intake of green tea supplement should be taken with exceptional care as acute liver toxicity has been reported in numbers of medical literature.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women 

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM.(PubMed)
(2) (Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea by Tomaszewska E1, Dobrowolski P2, Winiarska-Mieczan A3, Kwiecień M3, Tomczyk A4, Muszyński S5, Radzki R4.(PubMed)

(3) Green tea with a high catechin content suppresses inflammatory cytokine expression in the galactosamine-injured rat liver by Abe K1, Ijiri M, Suzuki T, Taguchi K, Koyama Y, Isemura M.(PubMed)

Herbal Therapy: Green Tea in Alleviated Symptoms, Onset, Recurrence and Treatment of Gout

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced onset and treatment of gout and recurrent gout, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Gout is a condition of  recurrently inflammatory arthritis characterized by a red, tender, hot, and swollen joint caused by over expression of purine in the body.

According to the study, green tea and its bioactive compoud Epigallo catechin-O-gallate (EGCG) may be considered as a putative curative drug for various diseases of gout, through its properties in reduced vascular endothelial growth factor receptor 2 (VEGFR2) in response to vascular endothelial growth factor signal (VGFG) for formation of gout through expression of levels of uric acid.

The study also emphasized that green tea with high levels of antioxidant and function in stimulated production of natural antioxidant in the body may also be used to reduce symptoms of recurrently inflammatory arthritis and inflammatory arthritis such as gout, through inhibiting the oxidative stress in induced  production of inflammatory cytokines to facilitate symptoms of inflammation. 

The above differentiation were supported by the study of the effect of EGCG on monosodium urate monohydrate (MSU)-induced inflammation and cryopyrin (NLRP3 inflammasome) activation in C57BL/6 mice received subcutaneous injection or oral gavage of EGCG before the intraperitoneal injection of MSU.

Truly, the application green tea EGCG decreased expression of gouty arthritis caused by injection of  MSU-induced neutrophil infiltration with function to initiate inflammation in the acute phase of infection and IL-1β secretion, in response and resistance to pathogens, but can also exacerbate damage during chronic disease and acute tissue injury.

The injection of green EGCG also decreased MSU-triggered neutrophil cytosolic factor 1, in activated inflammatory response to optimize healing and reduce injury to the body but the proteins has been found to cause severed damage to the infectious site and NLRP3 protein expression in initiated systematic inflammatory expression.

Moreover, the effect of green tea in protection against gout occurrence also limited pro-inflammatory mediator secretion interleukin 1 beta (IL1β), a mediator of inflammation, in response to acute phase infection, interleukin 6 (IL-6) produced by large amount at sites of acute and chronic inflammation, monocyte chemoattractant protein-1 in regulated monocytes, memory T cells, and dendritic cells to the sites of inflammation, and serum amyloid A, the serum was found to increase substantially in patient of chronic inflammatory disease.without limiting the function of the mediators in protect the infectious site against pathogens invasion.

More profoundly, the efficacy of green tea in reduced recurrent gout also extended to suppress NLRP3 inflammasome in stimulated caspase-1 in promoted secretion of others proinflammatory cytokines activation.

Dr. Jhang JJ, the lead author said, "EGCG treatment ameliorates MSU-induced inflammation, suggesting that EGCGexerts anti-inflammatory effect against MSU-induced acute gout attack."

Additionally to above study, the University of Pretoria suggested that polyphenols extracted from green tea also exhibited antioxidant effect in reduced  pronounce of oxidative stress by their antioxidant properties.

Catechin (C) (Ki = 303.95, uncompetitive), epicatechin (EC) (Ki = 20.48, mixed), epigallocatechin (EGC) (Ki = 10.66, mixed), epicatechin gallate (ECg) (Ki = 2.86, mixed) and epigallocatechin gallate (EGCg) (Ki = 0.76, competitive) were found to have similar efficacy as allopurinol (Ki = 0.30, mixed), the drug used to inhibit the levels of xanthine oxidase (XO) in gout patients, through reduced reactive oxygen species in initiated oxidative stress in induction of inflammatory symptoms.

Taken together, green tea and its bioactive polyphenols may be considered as a functional food for reduced onset, and combined with conventional medicine for treatment of gout without inducing any adverse effects.

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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) [Multiple actions of EGCG, the main component of green tea].[Article in French] by L'Allemain G1.(PubMed)
(2) Epigallocatechin gallate inhibits urate crystals-induced peritoneal inflammation in C57BL/6 mice by Jhang JJ1, Lu CC1, Yen GC2.(PubMed)
(3) Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis) by Aucamp J1, Gaspar A, Hara Y, Apostolides Z.(PubMed)
(4) Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication by Jhang JJ1, Lin JH1, Yen GC1.(PubMed)
(5) Association and interaction effect between VEGF receptor-2 (VEGFR-2) gene polymorphisms and dietary pattern on blood uric acid in Malays and Indians by Roseline YW1, Shidoji Y1, Hon WM2, Masaki M1.(PubMed)