Food Therapy: Chickpeas Isoflavones In Ameliorated Risk and Treatment of Breast cancer

Kyle J. Norton

Scientists may have found an ingredient from Chickpeas with substantial and potential impact in breast cancer risk, some studies suggested.

Isoflavones are phytoestrogens derived  from plant with magnificent estrogenic properties.
Garbanzo beans also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to Middle East.

The investigation of  the effects of isoflavones extracted from chickpeas in ameliorated risk and treatment of breast cancer was found to associate to numbers of aspects and mechanisms.

In deed, injection of isoflavones isolated from seeds and sprouts of chickpeas displayed a significant effect in inhibition of human breast cancer cell lines SKBr3 and Michigan Cancer Foundation-7 (MCF-7) at dose of ICS  at 10-60 µg/mL.

According to the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays, the phytochemicals significantly restrained the proliferation of both cell lines in a time-dependent and dose-dependent fashion.

Additionally observation based on results from Wright-Giemsa staining as well as annexin V-fluorescein isothiocyanate and propidium iodide (Annexin V/PI) staining, the inhibition of the phytoestrogen administration also can be seed through increased cytoclasis and physical body of cells death.

Cytoclasis is the presence of destruction of cells by fragmentation

Quantitative Annexin V/PI assays further showed that increased dose of isoflavones application resulted in increased number of apoptotic cells.

In fact, the effect of ICS in promoted apoptosis of both cancer cell lines may also be a result of activation of the expression of gene Bcl-2-associated X protein in induced cell death and decreased gene Bcl-2-in expression of anti apoptotic activity, observed by the semiquantitative reverse transcription PCR.

Bcl-2 family protein is a modulator responsible for regulation of cell apoptosis.

Further Western blot analysis also found that ICS injection also expressed a significantly restricted proliferation of cancer cell lines SKBr3 and MCF-7 through the increased expression of caspase 7, caspase 9 in regulated cell apoptosis and  tumor suppressors P53, and mediator of cell cycle arrest  P21 in a dose-dependent manner. 

Interestingly, in flow cytometry assays using the fluorescent probe 3,3'-dihexyloxacarbocyanine iodide showed a dose-dependent in decreased mitochondrial membrane potential following ICS treatment.

Treatment using ICS also increased reactive oxygen species production that can be deadly to cancer cell  through elevating toxicity without harming nearby healthy cells.

Deceased mitochondrial membrane potential may deplete cell energy which plays an important role for cancer cells survival and proliferation.

Truly, the effect of isoflavones in target breast cancer would vary from being antiestrogenic to weakly estrogenic depending to the high or low endogenous estrogen levels in patients.

Further more, in compared to the soybean-derived protease inhibitor Bowman-Birk inhibitor (BBI), is currently showing great promise as a novel cancer chemopreventive agent and 7 protease inhibitor concentrates (PIC) isolated from various leguminous sources (including soybean)to evaluate the effects of PIC on the proliferation of breast cancer cell line MDA-MB-231, application of chickpea PIC demonstrated a significantly inhibited viability of the cancer cell line at concentration doses of 25-400 μg/ml.

Protease inhibitors are class of anti viral medicine with function binding to viral proteases to prevent replication.

Finally, although epidemiological studies suggest that isoflavones can decrease breast cancer risk and increase survival of breast cancer patients but the University of Houston has raised several questions of the results by stating, "the effects of isoflavones on mammary gland stem cells during different periods of life need to be defined to identify windows of time in which isoflavones can have positive or negative effects on cancer prevention. Investigations of the effect of isoflavones on breast cancer stem cells would increase our knowledge of whether isoflavones are beneficial or not to cancer patients. Lastly, the possibility that isoflavones have different effects on breast cancer risks between different ethnic groups with different genetic backgrounds needs to be taken into account".

Taken together, chickpeas phytochemical may have a potential effect in reduced risk and treatment of breast cancer, but a complex and large sample size with different ethnic groups with different genetic backgrounds study are necessary to reaffirm this viability.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources

(1) Isoflavones extracted from chickpea Cicer arietinum L. sprouts induce mitochondria-dependent apoptosis in human breast cancer cells by Chen H1, Ma HR, Gao YH, Zhang X, Habasi M, Hu R, Aisa HA.(PubMed)

(2) Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrates inhibit breast and prostate cancer cell proliferation in vitro by Magee PJ1, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR.(PubMed)

(3) Does consuming isoflavones reduce or increase breast cancer risk? byBondesson M1, Gustafsson JA.(PubMed)

Food Therapy: Beet Juice May be Potent Function Foods For Reduced Risk and Treatment of Pharynx Cancer

Kyle J. Norton

Beet may be a potential functional food for reduced risk and treatment of pharynx cancer, a recent study suggested

Pharynx cancer in a medical condition of abnormal cell growth in the pharynx region, including neopharynx, hypopharynx, pharyngeal areas. In the late stage, the cancerous cells may travel a distance away to infect other healthy tissues.

Beet, best known as the beetroot or garden beet is a perennial plant with leafy stems growing to 1–2 m tall, belonging to the amaranth family.

According to the joint study lead by the Vels University, phyto-synthetic method of producing silver nanoparticles (Ag-NPs) may be used as mediator of beet root in enhanced treatment of patients with pharynx cancer.

In pharynx cancer cell line, the silver nanoparticles enhanced by beet root effect through induction of  cytotoxicity to cause cells death, without harming the nearby healthy cells.

Silver nanoparticles used to enhanced the function of biological treatment alone or combined with other pharmaceutical substances.

Measured by MTT assay, the inhibition efficacy may depend to the higher concentration proportionally of the photosynthetic substance.

 AO/EtBr staining observations also found that Ag-NPs exhibited mechanism of cell death probably through the depolarization of mitochondrial membrane potential caused by depletion of energy in induced cells proliferation, subsequently, in cell apoptosis.

In fact, according to the World Cancer Research Foundation reports, strong evidence suggested that vegetables with high nitrate-containing such as beet may have potential therapeutic effect in reduced risk and treatment of various cancers, including cancer of pharynx.

Unfortunately, beet juice with high amount of nitrate may associate to gastric cancer risk according to the review of literature of a total of 22 articles consisting of 49 studies—19 studies for nitrates, 19 studies for nitrites, and 11 studies for N-nitrosodimethylamine (NDMA).

Further analysis, discovered that high nitrates intake was associated with a weak but statistically significant reduced risk of gastric cancer, and increased consumption of nitrites and N-nitrosodimethylamine, NDMA  may elevate the risk factors for gastric cancer.

But after taking account to other con founders, the risk of gastric cancer is not attributed by intake of  nitrate but nitrate beverage with N-nitrosodimethylamine (NDMA) contamination.

Taken together, beet and beet juice with high concentration of nitrate may be uses as functional food to ameliorated risk and treatment of pharynx cancer, but people with stomach ailment should avoid drinking any nitrate beverage with N-nitrosodimethylamine (NDMA) contamination.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) The impact of anticancer activity upon Beta vulgaris extract mediated biosynthesized silver nanoparticles (ag-NPs) against human breast (MCF-7), lung (A549) and pharynx (Hep-2) cancercell lines by Venugopal K1, Ahmad H2, Manikandan E3, Thanigai Arul K4, Kavitha K5, Moodley MK6, Rajagopal K7, Balabhaskar R8, Bhaskar M9.(PubMed)
(2) Dietary Nitrates, Nitrites, and Nitrosamines Intake and the Risk of Gastric Cancer: A Meta-Analysis by Peng Song,1,† Lei Wu,2,† and Wenxian Guan1(PMC)
(3) It is rocket science - why dietary nitrate is hard to 'beet'! Part II: further mechanisms and therapeutic potential of the nitrate-nitrite-NO pathway by Mills CE1, Khatri J2, Maskell P2, Odongerel C2, Webb AJ2.(PubMed)

Herbal Therapy: Green Tea Polyphenols in Attenuated Risk and Treatment of Bladder Cancer

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Green tea may have a therapeutic and sustainable effect in reduced risk and treatment of bladder cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Bladder cancer is medical condition characterized by irregular cell growth in the issues of bladder. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic provided by cancer.net, 90% of people with bladder cancer are older than 55, and the average age of people diagnosed with bladder cancer is 73

In the review of medical literature published online, green tea major catechin EGCG in reduced risk and treatment may be attributed to numbers of mechanisms.

In T24 human bladder cancer cell line, application of the chemopreventive/antiproliferative potential of (-)-epigallocatechin gallate (EGCG, the major phytochemical in green tea) induced anti malignant cell proliferation by modulating the expression of phosphatidylinositol 3' kinase/Akt in activated Bcl-2 family proteins with function in regulation of cell death, thus enhancing apoptosis of T24 bladder cancer cell line in dose- and time-dependent manner.

The phosphatidylinositol 3'-kinase/AKT pathway is a crucial regulator of cellular processes including cell proliferation and apoptosis.

Bcl-2 family proteins is a modulator responsible for regulation of cell apoptosis.

In C3H/HeN mice subcutaneously implanted with MBT-2 murine bladder tumor cells, administration of EGCGs physically attached onto the surface of nanogold particles pNG(EGCG-adsorbed pNG) exerted a significant anti cancer proliferation through induction of apoptosis.

This action of anti cancer effect was attributed to mechanism of EGCG-pNG in activation of caspases which plays an important role in induced cell apoptosis and inflammation through Bcl-family proteins with function in control apoptosis by activating caspase proteases in the governing the space between outer and inner mitochondrial membrane.

Under stress, the mitochondrial pathway or the intrinsic pathway is activated depending to the release of proteins from the intermembrane space of mitochondria.

Caspase cascade, a family protease enzymes with function in programmed cell death and inflammation.

Additionally, injecting EGCG-pNG directly into the tumor site inhibited tumor expansion through ameliorated the function of vascular endothelial growth factor (VEGF) in stimulated formation of new blood vessel in provided nutrients and oxygen for survival of cancer site in compared to
oral administration of EGCG in stimulated immune function in suppression of cancer progression.

Vascular endothelial growth factor, is a signal protein produced by cells in stimulated formation of blood vessel for cell division and site proliferation.

Based on information collected,, the prepared EGCG-pNG was more effective than free EGCG in inhibiting bladder tumor in model mice.

More interestingly, bladder tumor induced by N-butyl-(-4-hydroxybutyl) nitrosaminre (BBN) 0.05% solution on 8 week-old female C3H/He mice for 14 or 24 weeks on treatment with or without green tea polyphenols (GTP) expressed a significant lower rate of tumor invasive frequency of 23.8%; in group treated with both GTP and BBN in compared to 65.2% in group treated with BBN alone.

The tumorvolume and microvascular density (MVD) as an independent predictor within a tumor.and  the connective, functionally supportive framework of a biological cell, tissue, or organ region in the BBN+GTP group were also significantly lower than in BBN treated mice.

Unbelievably, green tea polyphenols inhibited tumor growth and invasion in mice with established bladder cancer through regulation of angiogenetic effect in suppressed the forming of new blood vessel for the tumor cells proliferation, metastatic spread, as well as providing oxygen and nutrients and removal of waste products of cancer cells without exhibiting anti-carcinogenic effect.

Taken together, green tea extract polyphenols may be considered as adjunct therapy for reduced risk and used combination with standard medicine for treatment of bladder cancer.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins by Qin J1, Xie LP, Zheng XY, Wang YB, Bai Y, Shen HF, Li LC, Dahiya R.(PubMed)
(2) The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles by Hsieh DS1, Wang H, Tan SW, Huang YH, Tsai CY, Yeh MK, Wu CJ.(PubMed)
(3) Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer by Sagara Y1, Miyata Y, Nomata K, Hayashi T, Kanetake H.(PubMed)

Dietary Nitrate-Rich Beetroot Juice Improved Vascular Function In Reduced Risk of Heart Disease

Kyle J. Norton


Intake of nitrate-rich beetroot juice may have a substantial and profound effect in improved vascular function, thus reducing risk of heart disease.

Beet, best known as the beetroot or garden beet is a perennial plant with leafy stems growing to 1–2 m tall, belonging to the amaranth family.

Vascular function are bundle vascular system with function in blood circulation.

Abnormal vascular function is considered as one of the risk factor in development of cardiovascular disease.
In a total of 69 subjects recruited in this randomized, double-blind, placebo-controlled parallel study to examine the change in vascular function induced by intake of Nitrate-Rich Beetroot Juice, determined with the use of ultrasound flow-mediated dilatation (FMD).

The flow-mediated dilation (FMD).test, an ultrasound technique performed only by a skilled sonographer is a noninvasive assessment of vascular endothelial function through experts understanding of the physiology, analysis, and interpretation of this measurement

Intake of nitrate-rich beetroot juice displayed a significant increase in the FMD response of 1.1% in compared to placebo group of decrease of 0.3%

Nitrate-rich beetroot juice group also demonstrated a small improvement of stiffness measured by Aortic Pulse Wave Velocity and showed a trend of continuous improvement in compared to placebo.

Aortic Pulse Wave Velocity is a test to measure stiffness of the largest artery in the body, Increased stiffness will result in reduced mobility in related regions.

Result of aortic pulse wave velocity measurement is said to have an ability to identify people in their 20’s who are at increased risk for development of heart disease, stroke and dementia.

Administration of nitrate-rich beetroot juice showed a strong reduction of 7.6% of platelet-monocyte aggregates in compared to increase of 10.1% in placebo. This finding indicated that nitrate-rich beetroot juice intake had a substantial effect in decreased risk of acute myocardial infarction.

Platelet–monocyte aggregates is a novel index with platelet activation and a maker of early onset of acute myocardial infarction.

Furthermore, intake of nitrate-rich beetroot juice group expressed an exceptional improvement of vascular function in reduced P-selectin expression in activated platelet aggression

P-selectin is a cell adhesion molecule (CAM) with function in mediated the interaction of activated endothelial cells or platelets.

Additionally, application of the juice also improved the nonpathogenic, commensal bacteria present in the healthy human salivary glands measured by salivary microbiome in compared to placebo group.

Interestingly, intake of the nitrate-rich beetroot juice also responded to change of 78 bacterial taxa out of thousands harbored in human gut.

The proportions of Rothia mucilaginosa trending to increase in nitrate-rich beetroot juice group, in compared to Neisseria flavescens (P < 0.01) increased in the placebo group.

Rothia mucilaginosa, is considered part of the normal microflora of the human mouth and the upper respiratory tract.

Neisseria flavescens is an uncommon pathogen of human infection, pneumonia and empyema

There were no adverse effects of dietary nitrate were detected through out the experiment.

The findings evidences suggested that intake of nitrate-rich beetroot juice daily may have a sustainable effect in improve vascular function, thus reducing risk of heart disease.

Arthritis Is Curable

You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study by Velmurugan S1, Gan JM1, Rathod KS1, Khambata RS1, Ghosh SM1, Hartley A1, Van Eijl S1, Sagi-Kiss V2, Chowdhury TA3, Curtis M4, Kuhnle GG2, Wade WG5, Ahluwalia A6(PubMed)

Herbal Therapy: Green Tea Epigallocatechin-3-gallate (EGCG) In Reduced Risk and Treatment of Esophageal Cancer

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Green tea may have a therapeutic and positive effect in reduced risk and treatment of esophageal cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Esophageal cancer is medical condition characterized by irregular cell growth in the tissues of esophagus. At the later stage, the cancerous cells may travel a distance away to invade other healthy tissues and organs.
According to statistic, 2,300 Canadians will be diagnosed with esophageal cancer in 2017.

In the review of literature published online, green tea efficacy in treatment of human esophageal squamous cell carcinoma was expressed in number of mechanisms.

In esophageal cancer cell lines Eca109 and Ec9706, injection of green tea EGCG plus chemodrug adriamycin (ADM) after 24 hours displayed a significantly increased cellular apoptosis.

According to flow cytometry assay, the application induced the elevation of ROS and ADM concentration in production of toxicity to counter the reaction of tumor cell in diminished expression of mitochondrial membrane potential and ABCG2 protein to induced apoptosis.without harming to healthy cells.

ABCG2 protein expression plays a major role in multi-drug resistance, produced by tumor cells to accounter reaction to chemo-medicine.
Mitochondrial membrane potential is a central intermediate in oxidative energy metabolism, the deceased levels caused by toxicity ROS may result in energy deletion and subsequently, causing cells death.

Further observation also indicated that EGCG inhibited the growth of Eca109 and Ec9706 cells through ameliorated the anti apoptotic bcl-2 protein expression and promoted bax and caspase-3 protein expressions with functions in induced apoptosis in a dose- and time- dependent manner.

BCL2 family members form hetero- or homodimers and plays an important anti-apoptotic protein.

Caspase-3 protein.plays a central role in the execution-phase of cell apoptosis.

BAX gene. BAX is a member of the Bcl-2 gene family. plays an important role in mediation of cell death by apoptosis.

Compared to ADM treatment alone, the Eca109/ABCG2 multi-drug resistance cancer cells, rate of apoptosis and ADM concentration were significant higher anid levels of mitochondrial membrane potential and ABCG2 expression were lower.

In other word, injection of green tea plus ADM was more effective in induced cells death in Eca109/ABCG2 multi-drug resistance cancer cells with expression ROS and ADM in enhanced elevation cytotoxity activity in compared to ADM treatment alone.

After taking into account of others confounders, Dr, Liu L the lead author said, " EGCG inhibited cell growth and induced esophageal cancer cell apoptosis. It reduced the bcl-2 protein expression and increased the bax and caspase-3 protein expression. EGCG reversed multi-drug resistance by reducing ABCG2 expression and increasing the anticancer drug concentration in cancer cells".

In esophageal squamous cell carcinoma, application of Epigallocatechin-3-gallate (EGCG) without ADM measured by flow cytometry assay, after 24 hours also inhibited cancer site proliferation by increased expression of ROS to attenuate mitochondrial membrane potential function in energy metabolism and caspase-3 protein to cause malignant cellular apoptosis, in a dose-and time-dependent manner.

In the examine the PCR-TRAP argentation analysis during the experiment, EGCG was also demonstrated to inhibit the viability of Eca109 and Ec9706 cells by suppressing cancer cell in alternated DNA transcript through telomerase activity.

More interestingly, the continuation of study of epigallocatechin-3-gallate (EGCG) on the human esophageal cancer cell line ECa109 also discover that EGCG demonstrated a decrease of cancer cell viability but a substantial rate of apoptosis by increased expression of p16 gene demethylation in induced cancer cell cycle arrest and apoptosis, level p16 mRNA expression in suppressed tumor progression of invasive and aggressive behavior.and p16 protein expression in promoted tumor suppressible activity, in a dose- and time-dependent manner.

P16 gene demethylation plays an important role in cell cycle arrest and apoptosis. gene alternation was found in several types of cancer.

Low level of  p16 mRNA expression is associated to progression of  cancer with malignant and aggressive behavior.

Abnormalities of p16 gene and loss of p16 protein expression may be related to the pathogenesis and development of some cancers.

Taken together, green tea with abundance of phytochemical Epigallocatechin-3-gallate (EGCG) may be considered as an adjunct therapy to combine with standard chemo-medicine in reduced risk and treatment of esophageal cancer.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells by Liu L1, Ju Y2, Wang J3, Zhou R3.(PubMed)
(2) Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis in Ec9706 and Eca109 esophageal carcinoma cells by Liu L1, Zuo J1, Wang G1.(PubMed)
(3) Epigallocatechin-3-gallate inhibits growth and induces apoptosis in esophageal cancer cells through the demethylation and reactivation of the p16 gene by Meng J1, Tong Q2, Liu X2, Yu Z3, Zhang J3, Gao B3.(PubMed)

Alternative Therapy: Yoga Participated Attenuated Symptoms and Treatment of Depression

Kyle J. Norton

Good news for attendees in yoga lessons, some scientists suggested that yoga may be the best treatment used as adjunct intervention for patients with continued depressive symptoms despite antidepressant treatment.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate. Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself.

Antidepressant is a type of conventional medicine used as first line treatment of depression.

Yoga is an ancient practical technique of India, included breath control, meditation, bodily movement and gesture,..... with an aim to achieve harmonization of the body, mind, and spirit.

In a randomized controlled trial of weekly yoga classes (n = 63) vs health education classes (Healthy Living Workshop; HLW; n = 59) in individuals with elevated depression symptoms and antidepressant medication use. HLW served as an attention-control group, with intervention period of 10 weeks, with follow-up assessments 3 and 6 months afterwards, group attended yoga class showed decreased levels of depression in comparison to control group.
At 6-month follow-up, researchers found that 51% of yoga participants displayed an improvement of great than 50% in reduction in depression symptoms compared with 31% of HLW participants.

Healthy Living Workshop is a form of self management program with an aim to assist participants to learn self-management skills in dealing symptoms of their chronic condition, and emotions when living with a chronic condition..., particularly in patients with chronic depression. 

The program also is considered as a self care tool for caregivers, including family and friends caring for older adults suffering with chronic conditions to reduce personal stress, change negative self-talk....

In fact, yoga participation in deep relaxation and meditation creates a state of consciousness between waking and sleeping stage with an aim to improve sleep, calm the mind and ameliorate stress that may boost the production of hormone endorphins in reduced state of  depression.

Furthermore, deep breathing and meditation in yoga practice also promoted physical and mental health, particular for people struggling with depression and induced far fewer side effects and risk of potential drug interactions. Most students after taking yoga class for a few weeks also indicated that they have reduced intake of anti depressant doses.

Indeed, in compared to anti depressant in induced serious symptoms of mood disorder causing sadness and serious mental health issues accompanied with physical side effects of nausea and insomnia, yoga deep breathing and meditation eased the the above symptoms and side effect without the use of potentially harmful medication, the Journal of Alternative and Complementary Medicine study suggested.

Dr. Uebelacker LA, the lead author suggested, yoga participants expressed a fewer depression symptoms which was found over the entire follow-up period. the benefits of yoga may gradually accumulate over time.

Nevertheless, a recruited 38 adults in San Francisco meeting criteria for major depression of mild-to-moderate severity, per structured psychiatric interview and scores of 14-28 on Beck Depression Inventory-II (BDI) study also found that the efficacy of yoga in demonstration of decline in BDI scores than controls and yoga participants were more likely to achieve remission, defined per final BDI score ≤ 9 (p-value = 0.018)in adults with mild-to-moderate major depression.

Beck Depression Inventory-II (BDI) is a psychometric tests used to measure the severity of depression, containing questionnaire of 21-question multiple-choice self-report inventory.

And reduced BDI is an indication of improvement in compared to before intervention score.

Collectively, people with depressive syndrome may be benefits in reduction of symptoms, if participated in yoga class regardless to the treatment of antidepressant medicine.


For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN


Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Treating major depression with yoga: A prospective, randomized, controlled pilot trial by Prathikanti S1, Rivera R2, Cochran A3, Tungol JG4, Fayazmanesh N5, Weinmann E6.(PubMed)
(2) Adjunctive yoga v. health education for persistent major depression: a randomized controlled trial by Uebelacker LA1, Tremont G2, Gillette LT3, Epstein-Lubow G1, Strong DR4, Abrantes AM1, Tyrka AR1, Tran T2, Gaudiano BA1, Miller IW1.(PubMed)
(3) Treating major depression with yoga: A prospective, randomized, controlled pilot trial by Prathikanti S1, Rivera R2, Cochran A3, Tungol JG4, Fayazmanesh N5, Weinmann E6.(PubMed)

Herbal Therapy: Green Tea and Green Tea Epigallocatechin‑3-O-gallate (EGCG) In Ameliorated Risk and Treatment of Leukemia

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Green tea may have positive and potential effect in reduced risk and treatment of leukemia, according to studies of some scientists.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Leukemia is a malignant progressive disease characterized by irregular cell growth in the bone marrow and other blood-forming organs. According to the statistic, approximately Over 300 children with 0-14 years of age are diagnosed with leukemia each year in Canada alone.

In the review of literature published online, green extract epigallocatechin‑3-O-gallate (EGCG) processed a significant anti cancer effect in reduced chronic myeloid leukemia (CML) expansion in the myeloid cells through numbers of mechanisms.

Application of green tea epigallocatechin‑3-O-gallate (EGCG) in reduced risk of chronic myeloid leukemia (CML) was found to associate to the cellular process of cyclic guanosine monophosphate (cGMP)-dependent pathway and protein kinase Cδ expression to induce cancer cells apoptosis by increased acid sphingomyelinase (ASM) and lipid raft clustering in CML cells.

Acid sphingomyelinase (ASM), an enzyme plays an important role in normal membrane turnover.

Protein kinase Cδ expression plays a key role in signal transduction and are involved in the regulation of numerous cellular processes.

Cyclic guanosine monophosphate (cGMP)-is a important second messenger in many biological processes involved a series of molecular functions.

Further analysis also suggested that exhibited sGC function by injection of green tea EGCG, may be an ideal approach to suppresses proliferation and survival of human CML

In other words, reduced expression of regulation of sGC caused by decreased NO production may initiate growth and survival advantage in CML tumor cells.

Soluble guanylyl cyclase (sGC) is the only known receptor for nitric oxide.

Pharmacologically, pretreatment of soluble guanylate cyclase inhibitor NS-2028 decreased nitric oxide (NO)-stimulated sGC activity also reduced green tea polyphenol activities in activated sphingomyelinase (ASM) production.

NS-2028 is a specific inhibitor of soluble guanylyl cyclase.

In acute promyelocytic leukemia (APL), green tea (Camellia sinensis) catechin epigallocatechin-3-gallate (EGCG) displayed a strong and positive effect in elevating the expression of genes associated with cell cycle arrest and differentiation, including gene expression p27, PCAF, C/EBPα, and C/EBPɛ

P27, a cyclin-dependent kinase inhibitor 1B is an enzyme inhibitor and in elevation exerted positive regulation of cancer activity at the G1/S phase transition in cell division.

P300/CBP-associated factor (PCAF), is gene associated in binding to many sequence-specific factors involved in cell growth and/or differentiation.

Enhancer binding protein alphaC/EBPα, with function in modulated the expression of genes involved in cell cycle regulation.

Enhancer binding protein epsilon (C/EBPɛ) is a protein composed of two polypeptide chains with function in binding to certain DNA regulatory regions.

Additionally,injection of EGCG also demonstrated a hugh effect against cancerous changes in gene expression and reduced expression of epigenetic modifiers DNMT1, HDAC1, HDAC2, and G9a.

DNA Methyltransferase, (DNMT1), Methylation of DNA is an important component of mammalian epigenetic gene regulation.

Histone deacetylase 1and 2  (HDAC1 and 2) are enzymes promote epigenetic repression and with function in transcriptional regulation, cell cycle progression and development.

Euchromatic histone-lysine N-methyltransferase 2 (EHMT2) or G9a.is an epigenetic modifier enzymes with function in regulating gene expression involved functional role of cancer initiation and progression. Down regulation of G9a also decreased expression of histone H3K9 (H3K9me2) in inhibited cancer cells proliferation 

Other, in the multicenter case-control study conducted in China, 2008-2013, comprising 442 incident, hematologically confirmed adult leukemia cases and 442 outpatient controls, individually matched to cases by gender, birth quinquennium by the University of Western Australia also confirmed the inverse association of green tea intake to adult leukemia risk.

Risk of leukemia adjusted odds ratios of 0.50 was found in green tea drinkers in compared to non drinker, particularly in patients with GSTM1 and GSTP1 genotypes.

Dr. Liu P, the lead author said, "regular daily green tea consumption may reduce leukemia risk in Chinese adults regardless of GSTM1 and GSTP1 polymorphic status. The association between green tea and adult leukemia risk varied with GSTT1 genotype".

Taking altogether, green tea and epigallocatechin‑3-O-gallate (EGCG) intake may be considered as secondary therapeutic application combined with standard therapy for treatment of Leukemia regardless to polymorphic status.

For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA BURN

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells.by Huang Y1, Kumazoe M1, Bae J1, Yamada S1, Takai M1, Hidaka S1, Yamashita S1, Kim Y1, Won Y1, Murata M1, Tsukamoto S1, Tachibana H1.(PubMed)
(2) Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells by Borutinskaitė V1, Virkšaitė A1, Gudelytė G1, Navakauskienė R1.(PubMed)
(3) Green tea consumption and glutathione S-transferases genetic polymorphisms on the risk of adult leukemia by Liu P1, Zhang M2,3, Xie X4, Jin J5, Holman CD2.(PubMed)