Wednesday 11 October 2017

Herbal Therapy: Andrographis Paniculata, the Best Anti Skin Aging Natural herbal Medicine

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.

Andrographis paniculata, the forgotten herbal medicine may have a potential effect in delay skin aging, however, its therapeutic properties have rarely been applied in the field of skin care.

Skin aging, a naturally biological process caused by thinning of layer  just underneath the skin can not be prevented but delayed


Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...

According of the joint study lead by the Biospectrum Life Science Institute, in vitro, ex vivo, and in vivo, Andrographis paniculata extract (APE) exhibited a significant anti aging activity through ameliorate the process of loss of human epidermal stem cells (EpSCs).

Truly, the epidermal stem cells (EpSCs). treated with Andrographis paniculata extract (APE) exerted an anti aging effect by increased cells quantity significantly in the G2/M and S stages in cell division in a dose-dependent manner. 

The study also found that APE-treated EpSCs enhanced the Type 1 collagen production in normal human fibroblasts (NHFs).and improved skin hydration, dermal density, wrinkling, and sagging significantly.

In UV-Induced Skin Photoaging Andrographolide sodium bisulfate (ASB), a water-soluble form made from andrographolide increased the function of antioxidants in attenuated oxidative stress and inflammation responsible for ultraviolet (UV) irradiation causing skin damage and premature aging.
Dr. the lead anthor in the study of ultraviolet (UV) induced skin aging said, "topical administration of ASB suppressed the UV-induced skin thickness, elasticity, wrinkles, and water content, while ASB, especially at dose of 3.6 mg/mouse, increased the skin collagen content by about 53.17%, decreased the epidermal thickness by about 41.38%, and prevented the UV-induced disruption of collagen fibers and elastic fibers"

Furthermore, the study also proposed, the anti aging effect of the herbal Andrographis may be attributed  to anti enzymes in inhibited free radicals induced of oxidative stress and reduced the expression of pro inflammatory cytokins.

Taking together, Andrographis paniculata expressed significantly anti-skin aging effects through various mechanisms, but intake of large amount should be taken with care.



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Sources
(1) The Antiaging Properties of Andrographis paniculata by Activation Epidermal Cell Stemness by You J1, Roh KB2, Li Z3, Liu G4, Tang J5, Shin S6, Park D7, Jung E8.(PubMed)
(2) Andrographolide Sodium Bisulfate Prevents UV-Induced Skin Photoaging through Inhibiting Oxidative Stress and Inflammation by Janis Ya-Xian Zhan,1 Xiu-Fen Wang,1 Yu-Hong Liu,1 Zhen-Biao Zhang,1 Lan Wang,2 Jian-Nan Chen,1 Song Huang,1 Hui-Fang Zeng,2 and Xiao-Ping Lai1(Hindawi)

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