Wednesday 30 August 2017

Herbal Therapy: Chaste Tree Berry, the Best Anti Inflammatory Whole Food

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes has been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental source for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Chaste tree berry may process a strong anti inflammatory effect in reduced symptoms of reddened, swollen, hot caused by over reaction of immunity, a study suggested.

Inflammatory activity is an action of immune system taken to protect the body against injure and infection.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

According to the the Kyung Hee University, casticin a major compound found from Vitex species at doses of 1, 2, and 10mg/kg casticin via an i.p. injection to C57BL/6 mice, expressed a significant effect in inhibition the numbers of cells of neutrophils, macrophages, and lymphocytes through reduced the levels of proinflammatory cytokines and chemokines, as shown in the bronchoalveolar lavage Fluid (BALF), and lung histological analysis.

Further more, the tested compound also displayed a remarkably decreased the peribronchial thickening or bronchial wall thickening and perivascular inflammatory cells and the epithelium thickness in mice with lung inflammation, particular to chronic obstructive pulmonary disease (COPD).

In some newly found chemical compound isolated from Chaste tree berry, namely a phenylindene-type lignan, vitexdoin F (1), and three phenylnaphthalene-type lignans, vitexdoins G, H and I (2-4) in the testing of anti inflammatory activities, Compound 1 showed a significant inhibition on the nitric oxide (NO) production (IC50 4.17 μg/mL) in induced inflammation.

Other, in the evaluation of anti-arthritic activity of the extract of V. negundo seeds (EVNS) using Freund's complete adjuvant (CFA) induced arthritis (AA) in rat model, oral administrated rats showed a elevated anti inflammatory activities through suppressed paw edema, decreased the arthritis score, spleen index, and reversed the weight loss.

In fact, the efficacy of extract of Chaste tree berry in reduced inflammation may be resulted of suppressed expression of protein in regulated pro inflammatory cytokins in various inflammatory pathways.

Taking together,  phytochemical compounds found in Chaste tree berry may exhibit strong anti inflammatory properties through ameliorated the protein involved expression of proinflammatory 
cytokins.



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Sources
(1) Casticin, an active compound isolated from Vitex Fructus, ameliorates the cigarette smoke-induced acute lung inflammatory response in a murine model by Lee H1, Jung KH2, Lee H3, Park S4, Choi W5, Bae H6(PubMed)
(2) Anti-inflammatory and anti-osteoporotic lignans from Vitex negundo seeds by Zheng CJ1, Zhang XW2, Han T1, Jiang YP1, Tang JY3, Brömme D4, Qin LP5.(PubMed)

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