Wednesday 16 August 2017

Herbal Therapy: Chaste Tree Berry Anti Estrogenic Activity

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

If you expect that herbal medicine will ease the symptoms of your illness immediately, you will be disappointed. Symptoms of the diseases can only be eased gradually, depending to stage of the treatment which directly address to the cause of the disease.

Chaste tree berry(Vitex agnus-castus), is found to process anti estrogenic property in binding the estrogen receptors for a balance between the activities of estrogen receptor ERα or ERβ.

The herb is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Anti estrogenic effects is an action of binding the estrogen receptor(ERα ) and/ERβ in inhibiting the excessive levels of estrogen circulation in the body.

According to the University of Alabama in Huntsville, in the study of potential effect of estrogen mimics or anti-estrogens in phytochemicals of popular dietary herbal supplements, researchers found that almost all herbal supplements containing phytochemical components showed a capability in binding to the human estrogen receptor and exhibit selective estrogen receptor modulation, including chaste tree berry.

Casticin, a flavonoid isolated from Vitex rotundifolia, significantly expressed anti estrogenic effect in reduced the prolactin release stimulated by E2 in induced inhibition of ERα mRNA expression in a concentration-dependent manner, through its anti estrogenic effect.

In a hyperprolactinemia (MIHP) induced by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d) in SD rats, rat treated with casticin (10, 20, and 40 mg/kg, ip, for 7 d) reduced serum prolactin levels by 33.9%, 54.3%, and 64.7% and at(1 and 10 micromol/L)  inhibited E2-induced pituitary cell proliferation by 27.7% and 42.1%, respectively through reduced levels of 17β-Estradiol (E2) significantly.

More importantly, oral administration of casticin, a flavonoid isolated from Vitex rotundifolia displayed an anti estrogenic activity in decrease excessive levels of 17β-Estradiol (E2) significantly 

Taking together, Chaste tree berry processes strong estrogenic and anti estrogenic effects in binding estrogen receptor site to preserve the balancing of hormone expression of estrogen through ER alpha and ERBeta inhibition and exhibition.
 


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Sources
(1) A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements by Powers CN1, Setzer WN1.(PubMed)
(2) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP.(PubMed)

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