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Thursday, 30 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Treatment - The Medications of Gabapentin, duloxetine or pregabalin if neuropathic pain

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment


In conventional medicine perspective
FM usually involves females, particular to women entering stage of menopause. But it is often diagnosed both in young as well as elderly individuals. Diagnosis of pediatric FMS is a lengthy and frustrated condition affecting children and adolescents physical and emotional development, as the disease mimicked a spectrum of inflammatory joint disorders such as juvenile idiopathic arthritis (JIA), juvenile ankylosing spondylitis, etc, according to the study by Soroka Medical Center, Beer-Sheva(193)
A.2. Medications
3. Gabapentin, duloxetine or pregabalin if neuropathic pain
Neuropathic pain is a improper healing of injure tissue causing nerve fiber damage in sending uncorrected information to other pain centers, medication used for treatment of neuropathic pain of patient with fibromyalgia may include Gabapentin, duloxetine or pregabalin.
According to the Aristotle University of Thessaloniki, in the review of data base of research literature suggested, pregabalin (PB) at a dose of 450 mg per day is most likely effective in treating FBM, although AE are not negligible(219). Other study suggested gabapentin at doses of 1200 mg or more was effective for some people with some painful neuropathic pain conditions(220), including fibromyalgia.
The most common side effects of above medicine used for treatment of neuropathic pain include bot not limit to
Dizziness, drowsiness, dry mouth, edema (accumulation of fluid), blurred vision, double vision (diplopia), weight gain, fatigue (tiredness), tremor and difficulty concentrating,... according to medicine net(221).

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References
(219) Gabapentin and pregabalin in the treatment of fibromyalgia: a systematic review and a meta-analysis by Tzellos TG1, Toulis KA, Goulis DG, Papazisis G, Zampeli VA, Vakfari A, Kouvelas D.(PubMed)
(220) Gabapentin for chronic neuropathic pain and fibromyalgia in adults by Moore RA1, Wiffen PJ, Derry S, Toelle T, Rice AS.(PubMed)
(221) side effects of pregabalin by Medicine net



Wednesday, 29 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Treatment - The Medications of Tricyclic antidepressants

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment



In conventional medicine perspective
FM usually involves females, particular to women entering stage of menopause. But it is often diagnosed both in young as well as elderly individuals. Diagnosis of pediatric FMS is a lengthy and frustrated condition affecting children and adolescents physical and emotional development, as the disease mimicked a spectrum of inflammatory joint disorders such as juvenile idiopathic arthritis (JIA), juvenile ankylosing spondylitis, etc, according to the study by Soroka Medical Center, Beer-Sheva(193)
A.2. Medications
2. Tricyclic antidepressants (if neuropathic, back or fibromyalgia pain) or tramadol; 
Fibromyalgia pain due to psychological syndrome may be treated with ricyclic antidepressants, a synthetic version of antidepressants such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs) and norepinephrine reuptake inhibitors (NRIs) through by blocking the serotonin transporter (SERT) and the norepinephrine
 transporter (NET)(215).  The medication through clinical expression have shown effectively for major treatment and management of fibromyalgia and other chronic pain syndromes(216).
. Dr. Lawson K said, "Tricyclic antidepressants are the most effective drugs in use so far, especially when administered in combination with other therapies (e.g., selective serotonin re-uptake inhibitors), which suggests modulation of the neurotransmitters serotonin and noradrenaline"(215).
Duloxetine, in 2 randomized, placebo-controlled, double-blind, parallel-group, 12-week trials of duloxetine in the treatment of fibromyalgia, has been shown to be an effective and safe treatment for attenuation of symptoms associated with fibromyalgia, particularly for women(217).

Most Common side effects, according to the Mayo Clinic, may include Dry mouth. Blurred vision. Constipation. Urinary retention. Drowsiness. Increased appetite leading to weight gain. .....(218)

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and restore your health naturally with Chinese diet

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References
(215) Tricyclic antidepressants and fibromyalgia: what is the mechanism of action? by Lawson K1.(PubMed)
(216) A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes by Godfrey RG1.(PubMed)
(217) Duloxetine and other antidepressants in the treatment of patients with fibromyalgia by Arnold LM1.(PubMed)
(218) Side effects of Tricyclic antidepressants (TCAs) by Mayo Clinic

Tuesday, 28 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Treatment - The Medications of Simple analgesics(

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment


In conventional medicine perspective
FM usually involves females, particular to women entering stage of menopause. But it is often diagnosed both in young as well as elderly individuals. Diagnosis of pediatric FMS is a lengthy and frustrated condition affecting children and adolescents physical and emotional development, as the disease mimicked a spectrum of inflammatory joint disorders such as juvenile idiopathic arthritis (JIA), juvenile ankylosing spondylitis, etc, according to the study by Soroka Medical Center, Beer-Sheva(193)
A.2. Medications
The aim of medicine is to relieve the symptoms of the disease
In a narrative review by the Indiana University School of Medicine, from meta-analyses and systematic reviews published since 2005. For a few medications, findings from multiple recent trials are synthesized if a systematic review had not yet been published. Classes of medications are first reviewed, include(211).
1. Simple analgesics(acetaminophen or nonsteroidal anti-inflammatory drugs)
The objective of analgesics is to reduce pain for patient with Fibromyalgia through their effects on the peripheral and central nervous system.
According to the National Cheng Kung University, R-Duloxetine and N-Methyl Duloxetine, the Novel Analgesics effectively alleviates intractable pain associated with diabetic peripheral neuropathy and fibromyalgia(212).
In a randomised, double-blind studies of eight weeks' duration or longer, comparing milnacipran with placebo or another active treatment in fibromyalgia in adults suggested, "Evidence available indicates that milnacipran 100 mg or 200 mg is effective for a minority in the treatment of pain due to fibromyalgia, providing moderate levels of pain relief (at least 30%) to about 40% of participants, compared with about 30% with placebo"(213).
 Most common adverse effects, according to share care include allergic(hoarseness, swelling, difficulty breathing, hives, itching, and rash)  gastrointestinal(stomach upset,constipation, diarrhea) symptoms and  dizziness, or headache(214)

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The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(211) Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews by Kroenke K1, Krebs EE, Bair MJ.(PubMed)
(212) R-Duloxetine and N-Methyl Duloxetine as Novel Analgesics Against Experimental Postincisional Pain. by Wang CF1, Russell G, Wang SY, Strichartz GR, Wang GK.(PubMed)
(213) Milnacipran for pain in fibromyalgia in adults by Cording M1, Derry S, Phillips T, Moore RA, Wiffen PJ.(PubMed)
(214) What are the side effects of analgesics? by  Share care


Monday, 27 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Treatment - Physical therapy

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment


 In conventional medicine perspective
FM usually involves females, particular to women entering stage of menopause. But it is often diagnosed both in young as well as elderly individuals. Diagnosis of pediatric FMS is a lengthy and frustrated condition affecting children and adolescents physical and emotional development, as the disease mimicked a spectrum of inflammatory joint disorders such as juvenile idiopathic arthritis (JIA), juvenile ankylosing spondylitis, etc, according to the study by Soroka Medical Center, Beer-Sheva(193)

A. Non medication
4. Physical therapy
Epidemiological studies suggested, physiotherapy may reduce overloading of the muscle system, improve postural fatigue and positioning, and condition weak muscles and reduce localized as well as generalized pain in short term(207). When use conjunction with Mind and body therapy, physiotherapy may improve the effectiveness of improving physical functioning, pain and low mood for adults with fibromyalgia(208).
In discussion of the treatment of physiotherapy, Dr. Winkelmann A and research team at the Klinikum der Universität München, insisted, "physical therapy with Low-to-moderate intensity aerobic exercise and strength training are strongly recommended"(209).
In deed, "the multimodal programme, (including those of above) incorporating deep water running (DWR) is a safe and effective intervention for fibromyalgia syndrome that is acceptable to patients" Dr. Cuesta-Vargas AI Dr. Adams N. said(210).

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and restore your health naturally with Chinese diet

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References
(207) Physical therapy in the treatment of fibromyalgia by Offenbächer M1, Stucki G.(PubMed)
(208) Mind and body therapy for fibromyalgia by Theadom A1, Cropley M, Smith HE, Feigin VL, McPherson K.(PubMed)
(209) [Physiotherapy and physical therapies for fibromyalgia syndrome. Systematic review, meta-analysis and guideline].[Article in German] by Winkelmann A1, Häuser W, Friedel E, Moog-Egan M, Seeger D, Settan M, Weiss T, Schiltenwolf M; Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften.(PubMed)
(210) A pragmatic community-based intervention of multimodal physiotherapy plus deep water running (DWR) forfibromyalgia syndrome: a pilot study by Cuesta-Vargas AI1, Adams N.(PubMed)

Sunday, 26 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Treatment - Exercise

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment


 In conventional medicine perspective
FM usually involves females, particular to women entering stage of menopause. But it is often diagnosed both in young as well as elderly individuals. Diagnosis of pediatric FMS is a lengthy and frustrated condition affecting children and adolescents physical and emotional development, as the disease mimicked a spectrum of inflammatory joint disorders such as juvenile idiopathic arthritis (JIA), juvenile ankylosing spondylitis, etc, according to the study by Soroka Medical Center, Beer-Sheva(193)

A. Non medication
3. Exercise
Exercise is an effective treatment strategy for treatment of various chronic musculoskeletal pain disorders, including chronic neck pain, osteoarthritis, headache, fibromyalgia and chronic low back pain. But the therapy may be individually tailored with emphasis on prevention of symptom flares, (201).
The review of data base of literature from inception to October 2013 showed that aquatic training is beneficial for improving wellness, symptoms, and fitness in adults with fibromyalgia, except in muscle strength (very low quality evidence favoring land)(202).
On resistance exercise training, moderate- and moderate- exercise may improve multidimensional function, pain, tenderness, and muscle strength in women with fibromyalgia, the University of Saskatchewan study insisted(203).
Swimming, like walking, is an effective method for reducing pain and improving both functional capacity and quality of life in patients with FM(204).
Nordic walking twice a week for 15 weeks improved functional capacity and a decreased level of activity limitations except pain severity(205).
The result of moderated exercise in reduced symptoms of fibromyalgia probably is a result in decreasing their sensitivity to pain, via improving the functional capacity of the pain modulatory system in central nervous system(206).

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The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(201) Dysfunctional endogenous analgesia during exercise in patients with chronic pain: to exercise or not to exercise? by Nijs J1, Kosek E, Van Oosterwijck J, Meeus M.(PubMed)
(202) Aquatic exercise training for fibromyalgia by Bidonde J1, Busch AJ, Webber SC, Schachter CL, Danyliw A, Overend TJ, Richards RS, Rader T.(PubMed)
(203) Resistance exercise training for fibromyalgia by Busch AJ1, Webber SC, Richards RS, Bidonde J, Schachter CL, Schafer LA, Danyliw A, Sawant A, Dal Bello-Haas V, Rader T, Overend TJ.(PubMed)
(204) Swimming Improves Pain and Functional Capacity of Patients with Fibromyalgia: A Randomized Controlled Trial by Fernandes G1, Jennings F1, Nery Cabral MV1, Buosi AL1, Natour J2.(PubMed)
(205) Does moderate-to-high intensity Nordic walking improve functional capacity and pain in fibromyalgia? A prospective randomized controlled trial by Mannerkorpi K1, Nordeman L, Cider A, Jonsson G.(PubMed)
(206) Exercise Strengthens Central Nervous System Modulation of Pain in Fibromyalgia by Ellingson LD1, Stegner AJ2,3, Schwabacher IJ4,5, Koltyn KF6, Cook DB7,8.(PubMed)


Saturday, 25 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Treatment - Cognitive-behavioral and operant-behavioral therapy

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment


 In conventional medicine perspective
FM usually involves females, particular to women entering stage of menopause. But it is often diagnosed both in young as well as elderly individuals. Diagnosis of pediatric FMS is a lengthy and frustrated condition affecting children and adolescents physical and emotional development, as the disease mimicked a spectrum of inflammatory joint disorders such as juvenile idiopathic arthritis (JIA), juvenile ankylosing spondylitis, etc, according to the study by Soroka Medical Center, Beer-Sheva(193)
A. Non medication
2. Cognitive-behavioral and operant-behavioral therapy
Operant behavioural (OBT) and cognitive behavioural (CBT) therapies may also applied for
treatment of fibromyalgia syndrome (FMS). According to the University of Heidelberg, Central Institute of Mental Health, Operant behavioural (OBT) and cognitive behavioural (CBT) therapies reduced physical functioning, pain, affective distress, and cognitive and behavioural variables after 6 and 12 months treatment in patient with. Fibromyalgia(198).
Dr. Bernardy K and research team at the Ruhr University Bochum, said, " Cognitive behavioural therapies provided a small incremental benefit over control interventions in reducing pain, negative mood and disability at the end of treatment and at long-term follow-up"(199).

In a total of 125 patients fulfilled the American College of Rheumatology FMS criteria randomly assigned to CBT (n = 42), OBT (n = 43), or attention placebo (AP; n = 40), cognitive-behavioral therapy (CBT) and operant-behavioral therapy (OBT treatment expressed a clinically significant improvements in physical impairment. attenuated higher levels of affective distress, lower coping, less solicitous spouse behavior, and lower pain behaviors in FM patients(200).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(198) Psychological pain treatment in fibromyalgia syndrome: efficacy of operant behavioural and cognitive behavioural treatments by Thieme K1, Flor H, Turk DC.(PubMed)
(199) Cognitive behavioural therapies for fibromyalgia. by Bernardy K1, Klose P, Busch AJ, Choy EH, Häuser W(PubMed)
(200)  Responder criteria for operant and cognitive-behavioral treatment of fibromyalgia syndrome by Thieme K1, Turk DC, Flor H.(PubMed)


Friday, 24 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - Treatment In conventional medicine perspective

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment

 In conventional medicine perspective
FM usually involves females, particular to women entering stage of menopause. But it is often diagnosed both in young as well as elderly individuals. Diagnosis of pediatric FMS is a lengthy and frustrated condition affecting children and adolescents physical and emotional development, as the disease mimicked a spectrum of inflammatory joint disorders such as juvenile idiopathic arthritis (JIA), juvenile ankylosing spondylitis, etc, according to the study by Soroka Medical Center, Beer-Sheva(193)
A. Non medication
1. Psychological control
According to the study by Monash University and Monash Medical Centre, psychological control may play an important role in manage the emotional aspects and mood, stress, fatigue, and pain in patient with FM(194).
The Systematic review of psychological treatment in patients with FM, with a literature search of studies published between 1990 and 2012 using Medline and PsycINFO in the Ovid and ProQuest platforms and hand searching, indicated a description of the interventions developed by using psychological control and treatment in order to improve FM symptoms(195).
In FM pain control in comparison to other therapies, Dr. Thieme K and Dr. Gracely RH. said, "Relaxation as a single treatment has not been proven useful. Hypnotherapy and writing intervention have demonstrated mild treatment effects, whereas psychological treatment is effective in FM pain"(196).

A total of Fifteen women and 13 men selected to participate in nine weekly CBT-I sessions, involved completing several self-reported questionnaires at pretreatment, post-treatment, and follow-up conducted by the joint study led by the University of Granada, suggested, psychological treatment expressed the different results in gender related outcomes,  with "male group exhibited significant changes at post-treatment in sleep disturbances and pain-related anxiety and catastrophizing. The female group showed post-treatment improvements in sleep latency, general fatigue, and depression, which persisted at follow-up"(197).

(193) Pediatric fibromyalgia by Buskila D1, Ablin J.(PubMed)
(194) Psychological control is a key modulator of fibromyalgia symptoms and comorbidities by Malin K1, Littlejohn GO.(PubMed)
(195) Systematic review of psychological treatment in fibromyalgia by Lami MJ1, Martínez MP, Sánchez A.(PubMed)
(196) Are psychological treatments effective for fibromyalgia pain? by Thieme K1, Gracely RH.(PubMed)
(197) Gender Differences in Patients with Fibromyalgia Undergoing Cognitive-Behavioral Therapy for Insomnia: Preliminary Data by Lami MJ1, Martínez MP2, Sánchez AI2, Miró E2, Diener FN1, Prados G3, Guzmán MA3.(PubMed)

                             















                                

Thursday, 23 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The Anti inflammatory Antioxidants - Coenzyme Q10

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

           The  Anti inflammatory Antioxidants

Anti inflammatory Antioxidants play an critical role in induction of oxidative stress in the pathogenesis of a number of disorders inflammation, Fibromyalgia , rheumatoid arthritis, asthma, psoriasis and contact dermatitis(176),

4. Coenzyme Q10
CoQ10 treatment restored mitochondrial dysfunction and the mtDNA copy number, decreased oxidative stress, and increased mitochondrial biogenesis. The results suggest that CoQ10 could be an alternative therapeutic approach for FM(189). According to the University of SevillaSevilla, CoQ10 inhibited depressive symptoms in fibromyalgia through regulation of serotonin levels(190).
Oral supplementation showed an improvement in clinical symptoms and restored salivary cells (SCs) and mononuclear blood cells (BMCs) levels, in a study of 10 patients with intaking of supplemented daily with 300 mg of CoQ(10) during 3 months(191).
Dr. Alcocer-Gómez E and colleagues at the University of Seville said, " After treatment, all patients showed an important improvement in clinical symptoms in all evaluation methods. According to our results, and evaluated by three methods, patients with FM are candidates for treatment with CoQ10"(192).

(189) Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient by Cordero MD1, Cotán D, del-Pozo-Martín Y, Carrión AM, de Miguel M, Bullón P, Sánchez-Alcazar JA.(PubMed)
(190) Coenzyme q10 regulates serotonin levels and depressive symptoms in fibromyalgia patients: results of a small clinical trial by Alcocer-Gómez E1, Sánchez-Alcázar JA, Cordero MD.(PubMed)
(191) Coenzyme Q10 in salivary cells correlate with blood cells in Fibromyalgia: improvement in clinical and biochemical parameter after oral treatment by Cordero MD1, Santos-García R, Bermejo-Jover D, Sánchez-Domínguez B, Jaramillo-Santos MR, Bullón P.(PubMed)
(192) Effect of coenzyme Q10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: four case reports and literature review by Alcocer-Gómez E1, Cano-García FJ, Cordero MD.(PubMed)


Wednesday, 22 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The Anti inflammatory Antioxidants - Methylsulfonylmethane

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

           The  Anti inflammatory Antioxidants

Anti inflammatory Antioxidants play an critical role in induction of oxidative stress in the pathogenesis of a number of disorders inflammation, Fibromyalgia , rheumatoid arthritis, asthma, psoriasis and contact dermatitis(176),
3. Methylsulfonylmethane
Methylsulfonylmethane, also known DMSO2 is an organosulfur compound with the formula (CH3)2SO2 showed to exhibit anti inflammatory effects in attenuated production of mitochondrial reactive oxygen species (ROS)(185).
In a randomized, double-blind, placebo-controlled trial of Fifty men and women, 40-76 years of age MSM (3g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events, after 12 weeks(186)(187).
According to the joint study led by the Kangwon National University, Methylsulfonylmethane (MSM) inhibited expression of NLRP3(plays a crucial role in innate immunity and inflammation) in attenuated production of mitochondrial reactive oxygen species (ROS) and pro inflammatory cytokines such as IL-1α, IL-1β, IL-6(188).
In support of the use of sulfur organic compound of Methylsulfonylmethane as clinical applications in the treatment of a number of conditions such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS, Dr. Parcell S said, " Methylsulfonylmethane (MSM), a volatile component in the sulfur cycle, is another source of sulfur found in the human diet. Increases in serum sulfate may explain some of the therapeutic effects of MSM, DMSO, and glucosamine sulfate. ......MSM may be effective for the treatment of allergy, pain syndromes, athletic injuries, and bladder disorders"(181).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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References
(185) Methylsulfonylmethane inhibits NLRP3 inflammasome activation by Ahn H1, Kim J1, Lee MJ1, Kim YJ2, Cho YW3, Lee GS4.(PubMed)
(186) Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. by Kim LS1, Axelrod LJ, Howard P, Buratovich N, Waters RF.(PubMed)
(187) Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study by Debbi EM1, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N, Elbaz A, Beer Y, Debi R.(PubMed)
(188) Methylsulfonylmethane inhibits NLRP3 inflammasome activation by Ahn H1, Kim J1, Lee MJ1, Kim YJ2, Cho YW3, Lee GS4.(PubMed)



Tuesday, 21 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The Anti inflammatory Antioxidants - DLPA (dl- phenylalanine)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

           The  Anti inflammatory Antioxidants

Anti inflammatory Antioxidants play an critical role in induction of oxidative stress in the pathogenesis of a number of disorders inflammation, Fibromyalgia , rheumatoid arthritis, asthma, psoriasis and contact dermatitis(176),

2. DLPA (dl- phenylalanine)
DLPA, a mixture of D-Phenylalanine and L-Phenylalanine, is a nutritional supplement amino acid. Taltirelin, a thyrotropin-releasing hormone analog, showed effectively to relieve inflammatory persistent pain through iots antiallodynic action(182).
Dr. Bai Y and colleagues at the China Medical University, 4-Chloro-DL-phenylalanine, a derivative of DLPA inhibited metalloproteinase (TIMP)-1 and TIMP-2 in in response to many cytokines and hormones , including inflammatory cytokines in reduced pulmonary vascular remodeling and lunginflammatio(183).
Dr. Ehrenpreis S. in the study of D-phenylalanine and other enkephalinase inhibitors, said, "
D-phenylalanine, is also anti-inflammatory. D-phenylalanine has proven to be beneficial in many human patients with chronic, intractable pain" and "... may alleviate other conditions associated with decreased endorphin levels such as opiate withdrawal symptoms"(184).

(181) Sulfur in human nutrition and applications in medicine by Parcell S1.(PubMed)
(182) Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain by Eto K1, Kim SK, Nabekura J, Ishibashi H.(PubMed)
(183) 4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lunginflammation by Bai Y1, Wang HM1, Liu M1, Wang Y1, Lian GC1, Zhang XH1, Kang J2, Wang HL1.(PubMed)
(184) D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application by Ehrenpreis S.(PubMed)


Monday, 20 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The Anti inflammatory Antioxidants - Glucosamine and chondroitin

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

           The  Anti inflammatory Antioxidants

Anti inflammatory Antioxidants play an critical role in induction of oxidative stress in the pathogenesis of a number of disorders inflammation, Fibromyalgia , rheumatoid arthritis, asthma, psoriasis and contact dermatitis(176),
1. Glucosamine and chondroitin
Glucosamine used for treatment of osteoporosis and prevent the degenerative collagen, has been found to consist anti-inflammatory properties through reduction of the expression of proinflammatory cytokines such as C-reactive protein (hsCRP), interleukin (IL)-1β, IL-6(177). The supplement also exhibited a significant reduction in pain intensity at movement and resting state, according to a Russian study(178).
Dr. Fishman SM suggested, administration of Glucosamine and chondroitin may be used for management of pain in patients of Fibromyalgia(179). In a total of 71.4% women, and 65.0% with annual incomes of less than 25,000 dollars.researchers at the University of New Mexico Health Sciences Center indicated a higher percentage use of alternative medicine including oral supplement glucosamine and chondroitin for treatment with with osteoarthritis, rheumatoid arthritis, or fibromyalgia(180). Furthermore, the study also showed that use of alternative medicine was significantly associated with female, under 55 years of age, and having some college education(180).
Dr. Parcell S said, " ...sulfur compounds such as SAMe, dimethylsulfoxide (DMSO), taurine, glucosamine or chondroitin sulfate, and reduced glutathione may also have clinical applications in the treatment of a number of conditions such as depression, fibromyalgia,....."(181).

(176) Antioxidants and inflammatory disease: synthetic and natural antioxidants with anti-inflammatory activity by Geronikaki AA1, Gavalas AM.(PubMed)
(177) Associations between glucosamine and chondroitin supplement use and biomarkers of systemic inflammation by Kantor ED1, Lampe JW, Navarro SL, Song X, Milne GL, White E.(PubMed)
(178) [A role of melatonin in the treatment of low back pain].[Article in Russian] by Kurganova YM, Danilov AB.(PubMed)
(179) Carpal tunnel syndrome, diabetic neuropathy, fibromyalgia, glucosamine and chondroitin, hypnosis in pain management, marijuana for pain by Fishman SM1.(PubMed)
(180) Use of complementary therapies among primary care clinic patients with arthritis by Herman CJ1, Allen P, Hunt WC, Prasad A, Brady TJ.(PubMed)


Sunday, 19 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - The Free Radical scavengers - Vitamin E

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

                            The Free Radical scavengers

4. Vitamin E
According to Dr. Moriguchi S and Dr. Muraga M., vitamin E plays an essential role in enhanced immunity especially in cellular immunity with aging(171). Deficiency of vitamin E is found to induces the decreased differentiation of immature T cells associated to the increased infectious diseases and the incidence of tumors(171). According to the Suleyman Demirel University, intake of vitamins C and E (VCE) supplementation with exercise (EX) enhanced antioxidant vitamin and lipid peroxidation (LP) levels in blood of patients with fibromyalgia (FM)in protection of against FM-induced by oxidative stress(172).
Dr. Altindag O and Dr. Celik H. said, " patients with fibromyalgia are exposed to oxidative stress and this increased oxidative stress may play a role in the etiopathogenesis of the disease. Supplementation of antioxidant vitamins such as vitamins C and E to the therapy may be indicated"(173).
In support to the above analysis, Dr. Bagis S and colleagues at the Mersin University Medical School insisted, change of oxidant/antioxidant balances induced increase of free radical levels may be responsible for the development of fibromyalgia(174).
In fact, dietary consumption including vitamin E significantly reduced the levels of inflammation by analyzing the pro and anti-inflammatory cytokines in the blood serum(175).

(171) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)
(172) Vitamins C and E treatment combined with exercise modulates oxidative stress markers in blood of patients withfibromyalgia: a controlled clinical pilot study by Nazıroğlu M1, Akkuş S, Soyupek F, Yalman K, Çelik Ö, Eriş S, Uslusoy GA.(PubMed)
(173) Total antioxidant capacity and the severity of the pain in patients with fibromyalgia by Altindag O1, Celik H.(PubMed)
(174) Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? by Bagis S1, Tamer L, Sahin G, Bilgin R, Guler H, Ercan B, Erdogan C.(PubMed)
(175) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)


Saturday, 18 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - The Free Radical scavengers - Vitamin D

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

                            The Free Radical scavengers
3. Vitamin D
Deficiency of vitamin D is found to associate to nonspecific musculoskeletal pain. According to Maccabi Healthcare Services, improvement of levels of 25OHD reduced Polymyalgia pain induced by the use of statins(167). According to the Spine Unit, Center of Excellence for Orthopaedic Pain Management, oral administration of vitamin D reduced remarkably in pain of patient with FM in visual analog scale scores(168).
Dr. Matthana MH said, "Vitamin D deficiency has to be considered in the management of fibromyalgia syndrome" as "Among the 100 fibromyalgia women, there were 61 women with 25(OH) D deficiency; with vitamin D supplementation, only 42 women showed a significant improvement when their blood level of 25(OH) D became>or=30 ng/mL, this improvement became more significant when their blood level of 25(OH) D exceeded 50 ng/ mL"(169).
In support to the above diagnosis, evaluation of Saudi Arabia women, also showed a significant negative correlation between vitamin D level and widespread pain index(170).

(167) Muscle pain and serum creatine kinase are not associated with low serum 25(OH) vitamin D levels in patients receiving statins by Kurnik D1, Hochman I, Vesterman-Landes J, Kenig T, Katzir I, Lomnicky Y, Halkin H, Loebstein R.(PubMed)
(168) Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial by Wepner F1, Scheuer R2, Schuetz-Wieser B2, Machacek P2, Pieler-Bruha E2, Cross HS3, Hahne J2, Friedrich M2.(PubMed)
(169) The relation between vitamin D deficiency and fibromyalgia syndrome in women by Matthana MH1.(PubMed)
(170) Vitamin D deficiency in women with fibromyalgia in Saudi Arabia by Abokrysha NT1.(PubMed)


Friday, 17 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The Phytochemicals: Cucurbitacins

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                       The Phytochemicals

5. Cucurbitacins
Cucurbitacins found in the common pumpkins and gourds has found to process anti-inflammatory and analgesic activity in redued pain through inhibition of the neurogenic (first phase) and inflammatory phase (second phase) of formalin-induced pain(147). The phytochemical also inhibited pain caused by chronic rheumatic disease through anti pro inflammayory cytokine activity(148).
In neuro injure response, cucurbitacins displayed anti nitric oxide, prostaglandins and inflammatory cytokines, activation of complement proteins inducing neuro damage through activation of the neuroprotection of Nrf2/ARE pathway(149).
In chronic inflammatory model, cucurbitacin R, a derivative of Cucurbitacins, reduced over expression of proinflammatory enzymes, through reducetion of all mediators, such as prostaglandin E(2), nitric oxide, and TNF-alpha production in RAW 264.7 macrophages, as well as that for TNF-alpha in human lymphocytes(150).Dr. Yuan G and professors at the Zhejiang University said, "Natural products(including cucurbitacins) play a significant role in human health in relation to the prevention and treatment of inflammatory conditions"(151).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library,
Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(147) Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata by Peters RR1, Farias MR, Ribeiro-do-Valle RM.(PubMed)
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