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Thursday, 31 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): The Individual herbs - Stinging nettle

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)



Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.                                  

                                 Treatments

B.2. Herbal and Traditional Chinese medicine 
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including 
B.2.1. Individual herb
5. Stinging nettle
Sting Nettle is a flower plant in the genus Urtica, belongings to the family Urticaceae, native to Europe, Africa, Asia, and North America, used in traditional medicine as diuretic and laxative agent and to treat diarrhea and urinary disorders, to relieve pain, treat arthritis, asthma, bronchitis, sinusitis, etc. The potent herbal medicine may be used for relive pain, especially in inflammatory rheumatic disease(207). According to the University of California, extract of Urtica dioica (the stinging nettle) prepared using accelerated solvent extraction (ASE) involving water may be used for treatment of diseases associated to inflammatory disorders as the portion displayed significant anti-inflammatory activity through inhibited the pro inflammatory pathways(208).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies


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References
(207) Plant food supplements with anti-inflammatory properties: a systematic review (II). by Di Lorenzo C1, Dell'Agli M, Badea M, Dima L, Colombo E, Sangiovanni E, Restani P, Bosisio E.(PubMed)
(208) Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders by Johnson TA1, Sohn J, Inman WD, Bjeldanes LF, Rayburn K.(PubMed)

Wednesday, 30 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): The Individual herbs - Willow bark

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)



Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.                                  

                                 Treatments

B.2. Herbal and Traditional Chinese medicine 
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including 
B.2.1. Individual herb
4. Willow bark
A herbal medicine used over thousands of years for treatment as an anti-inflammatory, antipyretic, and analgesic advocate in many culture. According to the University College Dublin, in the testing of healthy adult, polyphenols found in willow bark (CMW) expressed significantly antiinflammatory properties through its polyphenols anti oxidant effect, by inhibiting pro inflammatory cytokines IL-1β, IL-6, and TNFα. inducing pain upon movement of joints specific to the knee and lower back.(204).
In the trail of total of 78 patients (39 willow bark extract, 39 placebo),. researcher sat the Universität Tübinge showed that Willow bark extract reduces pain, stiffness and improve physical function
(205), particular, pain reduction in short and long term usage for patients suffering from musculoskeletal disorders (MSD)(206).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Super foods Library
, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
References
(204) An in vivo study examining the antiinflammatory effects of chamomile, meadowsweet, and willow bark in a novel functional beverage by Drummond EM1, Harbourne N, Marete E, Jacquier JC, O'Riordan D, Gibney ER.(PubMed)
(205) Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial by Schmid B1, Lüdtke R, Selbmann HK, Kötter I, Tschirdewahn B, Schaffner W, Heide L.(PubMed)
(206) Willow bark extract STW 33-I in the long-term treatment of outpatients with rheumatic pain mainly osteoarthritis or back pain by Uehleke B1, Müller J, Stange R, Kelber O, Melzer J.(PubMed)




Tuesday, 29 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): The Individual herbs - Valerian

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)



Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.                                  

                                 Treatments

B.2. Herbal and Traditional Chinese medicine 
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including 
B.2.1. Individual herb
3. Valerian
Valerian is a perennial flowering plant, in the genus Valeriana, belongings to the family Valerianaceae, native to Europe and parts of Asia  used in traditional herbal medicine as a sedative and relaxing agent and to treat the liver, the urinary tract, the digestive tract problem, nerve conditions, etc.,...According to the University of Peshawar, Valerian expressed anti inflammatory effect on the acute and chronic phase inflammation models in male Wistar rats, on dose dependant manner(202), particular in crude extract at a dose of 200 mg/kg at all observed durations(203).
According to the University of Washington, Valerian may be used as sedative in reduced sleep(200) disturbance of patients induced fatigue(201) with inflammatory rheumatic pain(200).

(200) A feasibility study of valerian extract for sleep disturbance in person with arthritis by Taibi DM1, Bourguignon C, Gill Taylor A.(PubMed)
(201) Non-pharmacological interventions for fatigue in rheumatoid arthritis by Cramp F1, Hewlett S, Almeida C, Kirwan JR, Choy EH, Chalder T, Pollock J, Christensen R.(PubMed)
(202) Anti-inflammatory activity of the topical preparation of Valeriana wallichii and Achyranthes aspera leaves by Khuda F1, Iqbal Z, Khan A, Zakiullah, Nasir F, Shah Y.(PubMed)
(203) Antimicrobial and anti-inflammatory activities of leaf extract of Valeriana wallichii DC by Khuda F1, Iqbal Z, Zakiullah, Khan A, Nasir F.(PubMed)

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): The Individual herbs - Comfrey

         Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)



Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.           
   Treatments
          
B.2. Herbal and Traditional Chinese medicine 
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including 
B.2.1. Individual herb
1. Comfrey 
Comfrey is a perennial Plant in the genus of Symphytum, belongings to the family Boraginaceae, native to Europe,  used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relief pain and swollen, treat circulation issues, reduce cholesterol, etc. According to Merck Selbstmedikation GmbH, in the searching of the literature of multiple randomized controlled trials suggested that topical comfrey treatment significantly reduce pain, inflammation and swelling of muscles and joints in degenerative arthritis, acute myalgia in the back, sprains, contusions and strains after sports injuries and accidents, also in children aged 3 or 4 and over(194)
Dr. Staiger C said, "Comfrey root extract has been used for the topical treatment of painful muscle and joint complaints. It is clinically proven to relieve pain, inflammation and swelling of muscles and joints in the case of degenerative arthritis, acute myalgia in the back, sprains"(195).
Furthermore, the Universidade Federal dos Vales do Jequitinhonha e Mucur study in the investigation of the efficacy of comfrey expressed the promising result in control the inflammatory process and to induce collagen deposition at 8% concentration(196).

(194) Comfrey: a clinical overview by Staiger C1.(PubMed)
(195) Comfrey root: from tradition to modern clinical trials by Staiger C1.(PubMed)
(196) In vivo wound healing effects of Symphytum officinale L. leaves extract in different topical formulations by Araújo LU1, Reis PG, Barbosa LC, Saúde-Guimarães DA, Grabe-Guimarães A, Mosqueira VC, Carneiro CM, Silva-Barcellos NM.(PubMed)



                               

                              

                               
                          

Monday, 28 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): The Individual herbs - Devil's claw

     Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)



Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.      

                          Treatments

B.2. Herbal and Traditional Chinese medicine 
Herbal medicine from different cultures have been found effectively in reduced symptoms and treatment for patient with Polymyalagia Arthritis (Rheumatica), including 
B.2.1. Individual herb
2. Devil's claw
Devil's claw also known as wood spider, is a plant of genus Harpagophytum in the family of Pedaliaceae, native to South Africa.The plant has been used as herb in traditional and herbal medicine to treat fever, rheumatoid arthritis, skin, gallbladder, pancreas, stomach and kidneys conditions, etc. Because of its strongly anti inflammatory activities, the herb may be used to treat inflammatory rheumatic disease, causing pain, stiffness and tenderness in large muscles. According to University Hospital Zurich, Extracts of devil's claw inhibited a wide range of proinflammatory mediators(199) which are important in the pathophysiology of inflammatory rheumatic disease(197).
Dr. Chrubasik S said that preparations of devil's claw extract, should be taken account of the presence of the quantity of harpagoside of which has proven importantly in relived painful lower back or arthrotic pain as an attractive alternative to synthetic analgesics(198).

(197) Alteration of anti-inflammatory activity of Harpagophytum procumbens (devil's claw) extract after external metabolic activation with S9 mix by Hostanska K1, Melzer J, Rostock M, Suter A, Saller R.(PubMed)
(198) [Devil's claw extract as an example of the effectiveness of herbal analgesics].[Article in German] by Chrubasik S1.(PubMed)
(199) Inhibitory effects of devil's claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages by Inaba K1, Murata K, Naruto S, Matsuda H.(PubMed)




                   

Sunday, 27 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): The Preventive Minerals and Vitamins

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)


Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

                                                        Treatments

B. In herbal  and traditional Chinese medicine perspective
B.3. The Preventive Minerals and Vitamins
Certain minerals and vitamin such as  magnesium, selenium, copper and vitamin D may be a good sources of pain reliever according to the studies(325,180). According to the randomized to four double-blinded treatments for 12 weeks by Minnesota Applied Research Center, Glucosamine sulfate (1500 mg/d), Aquamin (2400 mg/d) and Combined treatment composed of Glucosamine sulfate (1500 mg/d) have shown effectively in improvements in symptoms of pain and stiffness of osteoarthritis(315,181).
1. Magnesium
Magnesium sulfate has shown to relieve pain in patients undergoing laparoscopic cholecystectomy (LC)(182) and neuropathic pain(183).
According to Dr. Sun J and the research team lead by the Wenzhou Medical University, magnesium used alone or conjunction with ropivacaine are effectively in exhibition of postoperative analgesia in children(184).
In fact, patient with chronic inflammatory diseases are found to associate to magnesium depletion. Dr. Nielsen FH. said," Magnesium deficiency should be considered a nutrient of significant concern for health and well-being"(185).

2. Selenium
Selenium therapy have shown to associate to pain reduction, according to study by Fourth Military Medical University(186).
In chronic pancreatitis, according to the systematic review and meta-analysis was performed per PRISMA guidelines, organic selenium may be effective for treatment of chronic pain as the result of reported change in pain score(187).
According to the Universidad de Buenos Aires, patient with chronic inflammatory diseases are found to have low levels of selenium serum(188).

3. Copper
Used topical Copper-salicylate gel has shown to relief pain for patients with the hip or knee osteoarthritis with side effects of skin rashes(330,189).
Other topical Cu-Indo gel has shown effectively against joint inflammation in the MIA-treated rat model of osteoarthritis(332,190). 
Deficiency of copper is found to associate with inflammation, oxidative Stress, and metabolic variables in adults, according to the 2008 American Society for Nutrition publication(191).

4. Vitamin D
According to the study by the University of Alberta, vitamin D may have beneficial effects in specific chronic painful conditions(192)and Vitamin D deficiency has recently been linked with a range of diseases including chronic pain(193).

All Forms of Arthritis are Curable

Ovarian Cysts And PCOS Elimination


References
(156) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans by Bjarnason I1, Hayllar J, MacPherson AJ, Russell AS.(PubMed)
(157) Adverse outcomes of antiinflammatory therapy among patients with polymyalgia rheumatica by Gabriel SE1, Sunku J, Salvarani C, O'Fallon WM, Hunder GG.(PubMed)
(325,180) Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis by Yazar M1, Sarban S, Kocyigit A, Isikan UE.(PubMed)
(325,181) Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis by Yazar M1, Sarban S, Kocyigit A, Isikan UE.(PubMed)
(182) Effect of intraoperative magnesium sulphate infusion on pain relief after laparoscopic cholecystectomy by Mentes O1, Harlak A, Yigit T, Balkan A, Balkan M, Cosar A, Savaser A, Kozak O, Tufan T.(PubMed)
(183) [Relief of neuropathic pain with intravenous magnesium].[Article in Japanese] by Tanaka M1, Shimizu S, Nishimura W, Mine O, Akatsuka M, Inamori K, Mori H.(PubMed)
(184) Pre-emptive peritonsillar infiltration of magnesium sulphate and ropivacaine vs. ropivacaine or magnesium alone for relief of post-adenotonsillectomy pain in children by Sun J1, Wu X2, Zhao X1, Chen F1, Wang W3.(PubMed)
(185) Effects of magnesium depletion on inflammation in chronic disease by Nielsen FH1.(PubMed)
(186) Antioxidant therapy for pain relief in patients with chronic pancreatitis: systematic review and meta-analysis by Cai GH1, Huang J, Zhao Y, Chen J, Wu HH, Dong YL, Smith HS, Li YQ, Wang W, Wu SX.(PubMed)
(187) Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis by Talukdar R1, Murthy HV2, Reddy DN3.(PubMed)
(188) Host selenium deficiency increases the severity of chronic inflammatory myopathy in Trypanosoma cruzi-inoculated mice by Gomez RM1, Solana ME, Levander OA.(PubMed)
(330,189) Copper-salicylate gel for pain relief in osteoarthritis: a randomised controlled trial.Shackel NA1, Day RO, Kellett B, Brooks PM.(PubMed)
(332, 190) Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis by Yassin NZ1, El-Shenawy SM1, Abdel-Rahman RF1, Yakoot M2, Hassan M3, Helmy S4.(PubMed)
(191) Associations of Dietary and Serum Copper with Inflammation, Oxidative Stress, and Metabolic Variables in Adults1,2 by Simona Bo3,*, Marilena Durazzo3, Roberto Gambino3, Carlo Berutti4,
Nadia Milanesio3, Antonio Caropreso4, Luigi Gentile5, Maurizio Cassader3,Paolo Cavallo-Perin3, and  Gianfranco Pagano3(The journal of nutrition)
(192) Vitamin D for the treatment of chronic painful conditions in adults by Straube S1, Derry S, Moore RA, McQuay HJ.(PubMed)
(193) Vitamin D Deficiency Linked to Depression, Pain, Inflammatory Bowel Disease, and Breast Cancer by Dr. Mercola

                   

Saturday, 26 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): The Nuts and seeds Olive

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)


Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

                                Treatments
 
B. In herbal  and traditional Chinese medicine perspective
3. Nuts and seeds Olive
Olive is belongs to the the family Oleaceae, native to the coastal areas of the eastern Mediterranean Basin and south end of the Caspian Sea. Its fruit, is also called the olive and the source of olive oil.

Olive Oil: Fat Content
1. Saturated fats
a. Palmitic acid
b. Stearic acid
c. Arachidic acid
d. ehenic acid
e. Myristic acid
f. Lignoceric acid
2. Unsaturated fat3. Monounsaturated fats
a. Oleic acid
b. Palmitoleic acid
3. Polyunsaturated fats
a. Linoleic acid
b. Linolenic acid

Monounsaturated fatty acids found abundantly in olive oil, may be beneficiary for reduced inflammation and induced antioxidation(362,175).
In a pilot double-blinded, randomized, clinical trial of topical virgin olive oil versus piroxicam gel in osteoarthritis of the knee, conducted by Ardabil University of Medical Science, researchers showed use of  olive oil in the experiment is more effective than medical gel for knee osteoarthritis, probably due to its phytochemiocals oleuropein and hydroxy tyroso(364,176).
Its omega-3 fatty acids component is also found to attenuate several inflammatory and degenerative diseases, through the expression of anti-inflammatory and immunomodulatory properties(177) of that may be potential effect for treatment of PMR, a low chronic inflammatory disease.
In chronic pain diseases, omega 3 fatty acids also exhibited anti analgesic property when it used either alone or in combination with morphine after acute and chronic administration in rats(178).
Dr. Ramsden CE and the research team lead by the National Institutes of Health suggested, with the biosynthetic precursors of endocannabinoids with antinociceptive, anxiolytic, and neurogenic, omega 3 fatty acids, could have physical and/or psychological pain modulating properties(179).

All Forms of Arthritis are Curable

Ovarian Cysts And PCOS Elimination

References
(156) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans by Bjarnason I1, Hayllar J, MacPherson AJ, Russell AS.(PubMed)
(157) Adverse outcomes of antiinflammatory therapy among patients with polymyalgia rheumatica by Gabriel SE1, Sunku J, Salvarani C, O'Fallon WM, Hunder GG.(PubMed)
(362,175) Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin expression by Musumeci G, Trovato FM, Pichler K, Weinberg AM, Loreto C, Castrogiovanni P.(PubMed)
(364,176) A pilot double-blinded, randomized, clinical trial of topical virgin olive oil versus piroxicam gel in osteoarthritis of the knee.in Bohlooli S1, Jastan M, Nakhostin-Roohi B, Mohammadi S, Baghaei Z.(PubMed)
(177) An update on the role of omega-3 fatty acids on inflammatory and degenerative diseases by Lorente-Cebrián S1, Costa AG, Navas-Carretero S, Zabala M, Laiglesia LM, Martínez JA, Moreno-Aliaga MJ.(PubMed)
(178) Analgesia enhancement and prevention of tolerance to morphine: beneficial effects of combined therapy withomega-3 fatty acids by Escudero GE1, Romañuk CB2, Toledo ME1, Olivera ME2, Manzo RH2, Laino CH1.(PubMed)
(179) Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress by Ramsden CE1, Zamora D2, Makriyannis A3, Wood JT3, Mann JD4, Faurot KR2, MacIntosh BA5, Majchrzak-Hong SF6, Gross JR7, Courville AB8, Davis JM9,Hibbeln JR6.(PubMed)



Friday, 25 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): The Salmon Calcitonin

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)


Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

                           Treatments
 
B. In herbal  and traditional Chinese medicine perspective
2. Cold water fish Salmon
Salmon is the common name for Salmonidae. They are anadromous, born in fresh water, migrate to the ocean, then travel thousands of miles in the deep sea cold water throughout their life cycle and within to five years returning to the exacted location where they were born to reproduce and die.

Nutrients
1. Protein
2. Omega-3 fatty acids
3. B vitamins
4. Vitamin D
5. Astaxanthin
is a potent antioxidant that stimulates the development of healthy fish nervous systems and enhances the fish's fertility and growth rate.
6. Selenium
7. Tryptophan
8. Magnesium
9. Phosphorus
10. Etc.

Use of salmon calcitonin, a hormone produced by the thyroid gland of salmon or a synthetic polypeptide of the same sequence found in salmon(360, 170) has shown to reduce PMR complications. Dr. Ryan SM and the research team at the Dublin Institute of Technology, suggested that salmon calcitonin may also portent for treatment of inflammatory arthritis through activation of the DNA expression of  of steroid-thyroid hormone-retinoid receptor and  tissue remodeling and degradation of the extracellular matrix (ECM) of  collagens, elastins, gelatin, matrix glycoproteins, and proteoglycan(172).
A randomized controlled trial of salmon calcitonin attenuate bone loss in corticosteroid-treated temporal arteritis and polymyalgia rheumatica patients by reducing the incidence of vertebral fracture of 12.5%, with four fractures in the first year and one fracture in the subsequent year(171).
In Fact, salmon calcitonin has also been used to reduce pain in patient with inflammatory arthritis diseases, including patient with osteoporotic vertebral crush fractures(173) and spinal pain(174).. through its analgesic effect , a prospective double-blind, randomized, placebo-controlled clinical study insisted

(362,170)
(171) A randomized controlled trial of salmon calcitonin to prevent bone loss in corticosteroid-treated temporal arteritis and polymyalgia rheumatica by Healey JH1, Paget SA, Williams-Russo P, Szatrowski TP, Schneider R, Spiera H, Mitnick H, Ales K, Schwartzberg P.(PubMed)
(172) An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis by Ryan SM1, McMorrow J, Umerska A, Patel HB, Kornerup KN, Tajber L, Murphy EP, Perretti M, Corrigan OI, Brayden DJ.(PubMed)
(173) Pain relief from nasal salmon calcitonin in osteoporotic vertebral crush fractures. A double blind, placebo-controlled clinical study by Lyritis GP1, Paspati I, Karachalios T, Ioakimidis D, Skarantavos G, Lyritis PG.(PubMed)
(174) Analgesic effect of salmon calcitonin suppositories in patients with acute pain due to recent osteoporotic vertebral crush fractures: a prospective double-blind, randomized, placebo-controlled clinical study by Lyritis GP1, Ioannidis GV, Karachalios T, Roidis N, Kataxaki E, Papaioannou N,
Kaloudis J, Galanos A.(PubMed)

   

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): Top foods to reduce risk of inflammation

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)


Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

                                             Treatments

B. In herbal  and traditional Chinese medicine perspective
B.1. Diet modification according herbal and TCM medicine specialist
1. Top foods to reduce risk of inflammation
Low-grade inflammation has found to play a pathophysiological role in patient with Polymyalgia Rheumatica(PMR), according to the University Giessen(158).According to Medical University Innsbruck, the relationship between diet, immunity, and the microbiota, may be necessary for us to rethink of the develop diet-based approaches to prevent or treat many diseases(283,159).
1. 1.Garlic
Garlic (Allium sativum) is a species in the onion genus, belongings to family Amaryllidaceae, native to central Asia, used popularly in traditional and Chinese medicine to treat common cold and flu, strengthen immunity, etc.... Recent studies also showed that garlic exhibits its anti-inflammatory effects against chronic inflammatory disease(160) through regulation of production of NO and pro-inflammatory cytokines and other mechanisms(161).

1.2. Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat rheumatoid arthritis and osteoarthritis. Recent study showed that ginger expressed its anti inflammatory effects through its mediators within the complexity of antioxidant activity(162).
According to the joint study of the Tshwane University of Technology, ginger's phytochemicals beside expressed its effects on anti-inflammation, it also exhibited a host of biological activities, ranging from anticancer, anti-oxidant, antimicrobial, and anti-allergic to various central nervous system activities(163).

1.3. Turmeric
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia. The herb has been used in traditional medicine as anti-oxidant, anti inflammations, etc. agent. Epidemiological studies also found that the efficacy of turmeric for treatment for low grade inflammatory diseases(164) through its anti inflammatory(165), antioxidant(165) and immunmodulatory activities.

1.4. Green tea
Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, green tea has been cultivated for commercial purposes all over the world. Epidemiological studies suggested that green tea improved chronic inflammatory diseases through its anti proinflammatory cytokines(166) and
 its antioxidant(168), anti inflammatory(167) and immune modulatory(169) activities.

(158) Ultrasonography of the glenohumeral joints--a helpful instrument in differentiation in elderly onset rheumatoid arthritis and polymyalgia rheumatica by Lange U1, Piegsa M, Teichmann J, Neeck G.(PubMed)
(283,159) Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease by Kirsty Brown,† Daniella DeCoffe,† Erin Molcan, and Deanna L. Gibson(PubMed)
(160) Short-term heating reduces the anti-inflammatory effects of fresh raw garlic extracts on the LPS-induced production of NO and pro-inflammatory cytokines by downregulating allicin activity in RAW 264.7 macrophages. by Shin JH1, Ryu JH, Kang MJ, Hwang CR, Han J, Kang D.(PubMed)
(161) aged black garlic exerts anti-inflammatory effects by decreasing no and proinflammatory cytokine production with less cytoxicity in LPS-stimulated raw 264.7 macrophages and LPS-induced septicemia mice. by Kim MJ1, Yoo YC, Kim HJ, Shin SK, Sohn EJ, Min AY, Sung NY, Kim MR.(PubMed)
(162) Evaluation of in vitro anti-inflammatory effects of crude ginger and rosemary extracts obtained through supercritical CO2 extraction on macrophage and tumor cell line: the influence of vehicle type. by Justo OR1, Simioni PU2, Gabriel DL2, Tamashiro WM2, Rosa Pde T3, Moraes ÂM4.(PubMed)
(163) Gingerols and shogaols: Important nutraceutical principles from ginger by Semwal RB1, Semwal DK1, Combrinck S2, Viljoen AM3.(PubMed)
(164) Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats by Leray V1, Freuchet B, Le Bloc'h J, Jeusette I, Torre C, Nguyen P.(PubMed)
(165) Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis by Ramadan G1, Al-Kahtani MA, El-Sayed WM.(PubMed)
(166) Green tea polyphenol epigallocatechin-3-gallate and cranberry proanthocyanidins act in synergy with cathelicidin (LL-37) to reduce the LPS-induced inflammatory response in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts by Lombardo Bedran TB1, Palomari Spolidorio D2, Grenier D3.(PubMed)
(167) Antiinflammatory action of EGCG, the main component of green tea, through STAT-1 inhibition by Tedeschi E1, Suzuki H, Menegazzi M.(PubMed)
(168) Antioxidant potential of green and black tea determined using the ferric reducing power (FRAP) assay by Langley-Evans SC1.(PubMed)
(169) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S3, Kwon SR4, Vanarsa K3, Kim HY5, Davis LS1, Mohan C3(PubMed)

      



Thursday, 24 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): Medical treatment In conventional medicine

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)


Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

                          Treatments


A. In conventional medicine perspective
A.2. Medical treatment
1. Tocilizumab (TCZ)
1.1. The effectiveness
Tocilizumab (TCZ),the first humanized anti proinflammatory agent in the interleukin-6 receptor-
inhibiting monoclonal antibody developed to treat rheumatoid arthritis, may also be efectively for treatment of PMR(152) becauses of its significant improvement of the patient's clinical and biochemical PMR activity(152).
In the study to assess the outcomes of 10 patients with relapsing/refractory GCA, TAK, or PMR treated with tocilizumab (TCZ), found that TCZ led to clinical and serological improvement in patients with PMR, through reduced symptoms of disease activity, inflammatory markers(153).

2.2. The adverse effects are not limit to
q. Dizziness
b. Headache
c. Allergic effects, such as rash; hives; itching; difficulty breathing, etc.
d. Skin changes
e. Tiredness or weakness
f. Etc.

2. Corticosteroids [CS] and nonsteroidal antiinflammatory drugs [NSAIDs])
2.1. Corticosteroids, a drug, a common presentation in primary care, and non-selective non-steroidal anti-inflammatory drugs (sometimes also referred to as traditional NSAIDs or tNSAIDs) are the first choice of treating of Polymalagia Arthritis, but the use of CS and NSAIDs in the treatment of PMR is associated with important long-term morbidity, according to Gabriel SE, Sunku J, Salvarani C.(154).
 The total of 176 patients in whom polymyalgia rheumatica (PMR) or giant cell arteritis (GCA) diagnosed between 1968 and 1980 study, treated with corticosteroids, showed no patient suffered a serious disease complication after starting treatment. Regular follow-up enabled the minimum effective corticosteroid dose to be used. Complications of treatment were infrequent(155).

2.2. The adverse effects ate not limit to
a. Corticosteroids [CS]
a.1. Corticosteroid withdrawal syndrome
a.2. Hyperglycemia
a.3. Insulin resistance
a.4. Diabetes mellitus
a.5. Osteoporosis
a.6. Depression
a.7. Colitis
a.8. Etc.

b. Nonsteroidal antiinflammatory drugs [NSAIDs]
NSAIDs may cause large intestinal ulcers, bleeding, and perforationoccasionally(156), mostly in duodenum of which represent a range of asymptomatic pathologies but some are life threatening(156).The use of the medication are also found to induce important long-term morbidity(157).

(152) Effective control of polymyalgia rheumatica with tocilizumab by Al Rashidi A1, Hegazi MO, Mohammad SA, Varghese A.(PubMed)
(153) Tocilizumab for the treatment of large-vessel vasculitis (giant cell arteritis, Takayasu arteritis) and polymyalgia rheumatica by Unizony S1, Arias-Urdaneta L, Miloslavsky E, Arvikar S, Khosroshahi A, Keroack B, Stone JR, Stone JH.(PubMed)
(154) Adverse outcomes of antiinflammatory therapy among patients with polymyalgia rheumatica by Gabriel SE1, Sunku J, Salvarani C, O'Fallon WM, Hunder GG.(PubMed)
(155) Polymyalgia rheumatica and corticosteroids: how much for how long? by Behn AR, Perera T, Myles AB.(PubMed)



Wednesday, 23 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): Non Medication In conventional treatment

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)


Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

                                                   Treatments


A. In conventional medicine perspective
A.1. Non Medication
1. Fasting as part of a naturopathic treatment
Fasting may be formed part of polymyalgia rheumatica (PMR) treatment, according to the Dr. Stange R. and Dr, Pflugbeil C. a complex therapy with methods of natural medicine comprising fasting as its main treatment element may be the best solution for treatment of the diseases(148), as the therapy has significant improvement of the immune condition of the intestine and consequently of the whole body(149).

2. Diet therapy
Leucine-rich milk and whey proteins may be a potential treatment of age related loss of muscle mass and strength, according to the study of Douglas Paddon-Jones and Dr. Blake B. Rasmussen(150). Other in a A randomized double blind crossover trial, suggested that exercise and amino acid supplementation (AAS) together may be effective in enhancing not only muscle strength, but also combined variables of muscle mass and walking speed and of muscle mass and strength in sarcopenic women(151).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(148) [Fasting as part of a naturopathic treatment approach for polymyalgia rheumatica].[Article in German] by Stange R1, Pflugbeil C.(PubMed)
(149)[Progression of intestinal secretory immunoglobulin A and the condition of the patients during naturopathic therapy and fasting therapy].[Article in German] by Beer AM1, Rüffer A, Balles J, Ostermann T.(PubMed)
(150) Dietary protein recommendations and the prevention of sarcopenia Protein, amino acid metabolism and therapy by Douglas Paddon-Jones and Blake B. Rasmussen(PubMed)
(151) Similar effects of leucine rich and regular dairy products on muscle mass and functions of older polymyalgia rheumatica patients: a randomized crossover trial. by Björkman MP1, Pilvi TK, Kekkonen RA, Korpela R, Tilvis RS.(PubMed)




Tuesday, 22 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): The Antioxidants

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)


Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

                        The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

1. Immune system and functioning (Free radical scavengers)
Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(176, 127)(177,128), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(178,129)(179,130). The domino effects have shown to induce many chronic illness, such as cancers(179,130).

a. Vitamin A
vitamin A plays an essential roles in enhancing a broad range of immune processes, including white blood cells activation and proliferation(180,132)of T-helper-cell differentiation, the production of specific antibody in regulation of the immune response(182,133).

b. Vitamin C
Due to recent promotion of western diet in some developed country, deficiencies of micronutrients are emerging as the limiting factors in ensuring children's optimal health, according Bayer Consumer Care Ltd(134). Deficiency of vitamin C and zinc in fact, interfere with normal children's growth and development(134). Researchers found that vitamin C raised the concentration in the blood of total immunoglobulin(183,135) in promotion of the ability of antibodies and phagocytic cells to clear pathogens(184,136).
c. Vitamin D
Deficiency of vitamin D is found to associate to nonspecific musculoskeletal pain. According to Maccabi Healthcare Services, improvement of levels of 25OHD reduced Polymyalgia pain induced by the use of statins(131).

c. Vitamin E
According to Dr. Moriguchi S and Dr. Muraga M., vitamin E plays an essential role in enhanced immunity especially in cellular immunity with aging(137). Deficiency of vitamin E is found to induces the decreased differentiation of immature T cells associated to the increased infectious diseases and the incidence of tumors(137)

d. Zinc
Zinc, having a regulatory role in the immune system, as a antioxidant is essential mineral improved immune system by enhancing the proper function of T and B cells(188,138) which belong to a group of white blood cells known as lymphocytes, in fighting against damaging free radicals(190,139).

2. Antioxidants and inflammation
Diet included  vitamin E significantly reduce the levels of inflammation by analyzing the pro and anti-inflammatory cytokines in the blood serum(193,140).
a. Glucosamine and chondroitin
Glucosamine used for treatment of osteoporosis and prevent the degenerative collagen, has been found to consist anti-inflammatory properties through reduction of the expression of proinflammatory cytokines such as C-reactive protein (hsCRP), interleukin (IL)-1β, IL-6(141). The supplement also exhibited a significant reduction in pain intensity at movement and resting state, according to a Russian study(142).
b DLPA (dl- phenylalanine)
DLPA, a mixture of D-Phenylalanine and L-Phenylalanine, is a nutritional supplement amino acid(196,143). Taltirelin, a thyrotropin-releasing hormone analog, showed effectively to relieve inflammatory persistent pain through iots antiallodynic action(144).

c.  Methylsulfonylmethane, also known  DMSO2 is an organosulfur compound with the formula (CH3)2SO2 showed to exhibit anti inflammatory effects in attenuated production of mitochondrial reactive oxygen species (ROS)(145).
In a randomized, double-blind, placebo-controlled trial of Fifty men and women, 40-76 years of age  MSM (3g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events, after 12 weeks(199,146)(200,147).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(177,128) Superoxide Anion and Its Functions(Beta Forces)
(178,129) Free radicals and antioxidants in normal physiological functions and human disease by Valko M1, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J.(PubMed)
(179,130) Free radicals, metals and antioxidants in oxidative stress-induced cancer by Valko M1, Rhodes CJ, Moncol J, Izakovic M, Mazur M.(PubMed)
(131) Muscle pain and serum creatine kinase are not associated with low serum 25(OH) vitamin D levels in patients receiving statins by Kurnik D1, Hochman I, Vesterman-Landes J, Kenig T, Katzir I, Lomnicky Y, Halkin H, Loebstein R.
(180,132) Cellular immunity in osteoarthritis: novel concepts for an old disease by Liossis SN1, Tsokos GC.(PubMed)
(182,133) Free Radicals, Antioxidants in Disease and Health by Lien Ai Pham-Huy,1 Hua He,2 and Chuong Pham-Huy3(PMC)
(134) Essential role of vitamin C and zinc in child immunity and health by Maggini S1, Wenzlaff S, Hornig D.(PubMed)
(183,135) New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate by Hae-Suk Kim,a Michael J. Quon,c and Jeong-a Kima,b(PMC)
(184,136) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications by Singh BN1, Shankar S, Srivastava RK.(PubMed)
(137) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)
(188,138) Green tea: a new option for the prevention or control of osteoarthritis by Katiyar SK, Raman C.(PubMed)
(190,139) Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans role of oxidative stress by K Esposito, F Nappo, R Marfella, G Giugliano, F Giugliano, M Ciotola(Circulation)
(193,140) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)
(141) Associations between glucosamine and chondroitin supplement use and biomarkers of systemic inflammation by Kantor ED1, Lampe JW, Navarro SL, Song X, Milne GL, White E.(PubMed)
(142) [A role of melatonin in the treatment of low back pain].[Article in Russian] by Kurganova YM, Danilov AB.(PubMed)
(196,143)
(144) Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain by Eto K1, Kim SK, Nabekura J, Ishibashi H.(PubMed)
(145) Methylsulfonylmethane inhibits NLRP3 inflammasome activation by Ahn H1, Kim J1, Lee MJ1, Kim YJ2, Cho YW3, Lee GS4.(PubMed)
(199, 146) Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. by Kim LS1, Axelrod LJ, Howard P, Buratovich N, Waters RF.(PubMed)
(200, 147) Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study by Debbi EM1, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N, Elbaz A, Beer Y, Debi R.(PubMed)






                                                   

Monday, 21 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): The Phytochemicals

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                     

                  Polymyalagia Arthritis (Rheumatica)


Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.
                       
                              The Phytochemicals 

Significantly inflammation has been found to accompany with patient with Polymyalgia Rheumatica(PMR). Certain phytochemicals have found effectively for treatment of  inflammatory symptoms of patient with PMR, including the following

1. Polyphenols(-)-epigallocatechin-3-gallate (EGCG)(Green tea)
Polyphenols(-)-epigallocatechin-3-gallate (EGCG) processed anti viral and bacterial effects through immune expression such as chronic or acute inflammation(115). Dr. Xiao J and the research team at the Shenzhen Institute of Advanced Technology suggested, pure extract of (-) epigallocatechin gallate (EGCG) inhibited inflammation through antioxidant activities against oxidative stress and down regulated pro-inflammatory markers(116).
According to the Universitat de Girona (UdG), Polyphenols(-)-epigallocatechin-3-gallate (EGCG) also showed to reduce pain in attenuated alterations by diminishing apoptotic gene overexpression in skeletal muscles(117)

2. Curcumin
Curcumin, a phytochemical found in turmeric used in the Indian cooking recipe has found to process the antioxidants and anti inflammatory effects, epidemiologically.
It inhibited muscle pain, muscle damage, inflammation and delayed onset muscle soreness, the SportsMed Canterbury study suggested.(118), through attenuatd inflammatory responses and production of reactive oxygen species (ROS) that sustain both inflammation and oxidative stress(119).
In fact Dr. Anand P and the research team at the University of Texas M.D. Anderson Cancer Center, said, curcumin beside inhibited pain in many therapeutic levels but also linked to suppression of inflammation; angiogenesis, tumorigenesis and diseases of the cardiovascular, pulmonary, and neurological systems(120).

3. Resveratrol
Resveratrol (RES), a well-known antioxidant and anti-inflammatorycompound, found abundantly in red wine, exerted numerous pharmacological effects, including hepatoprotection and cadioprotection(121). According to the University of Arizona study, resveratrol facilitated acute and chronic pain through activation of AMPK, the enzyme played a key role as a master regulator of cellular energy homeostasis(122).

4. Boswellic acid
Gum-resin extracts of Boswellia serrata have been traditionally used in folk medicine for centuries to treat various chronic inflammatory diseases. Recent study showed that the acid are also responsible for inhibition of pro-inflammatory enzymes(123). Dr Bishnoi M and the research team at the University Institute of Pharmaceutical Sciences, suggested that the phytochemical also may help to reduce the therapeutic doses of conventional NSAIDs and side effects when used conjunction with nimesulide(124).

5. Cucurbitacins 
Cucurbitacins found in the common pumpkins and gourds  processed anti-inflammatory and analgesic activity in reduced pain through inhibition of the neurogenic (first phase) and inflammatory phase (second phase) of formalin-induced pain(125). The phytochemical also  inhibit pain caused by chronic rheumatic disease through anti pro inflammayory cytokine activity(126).


(115) Compounds derived from epigallocatechin-3-gallate (EGCG) as a novel approach to the prevention of viral infections by Hsu S.(PubMed)
(116) Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways by Xiao J1, Ho CT, Liong EC, Nanji AA, Leung TM, Lau TY, Fung ML, Tipoe GL.(PubMed)
(116) (-)-Epigallocatechin-3-gallate (EGCG) attenuates functional deficits and morphological alterations by diminishing apoptotic gene overexpression in skeletal muscles after sciatic nerve crush injury by Renno WM1, Al-Maghrebi M, Al-Banaw A(PubMed)).
(118) Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS) by Nicol LM1, Rowlands DS, Fazakerly R, Kellett J.(PubMed)
(119) Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial by Drobnic F1, Riera J1, Appendino G2, Togni S3, Franceschi F3, Valle X4, Pons A5, Tur J5.(PubMed)
(120) Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.by Anand P1, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal BB.(PubMed)
(121) Resveratrol nanoparticle system improves dissolution properties and enhances the hepatoprotective effect of resveratrol through antioxidant and anti-inflammatory pathways by Lee CW1, Yen FL, Huang HW, Wu TH, Ko HH, Tzeng WS, Lin CC.(PubMed)
(122) Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain by Tillu DV1, Melemedjian OK, Asiedu MN, Qu N, De Felice M, Dussor G, Price TJ.(PubMed)
(123) Boswellia serrata, a potential antiinflammatory agent: an overview by Siddiqui MZ1.(PubMed)
(124) Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-betaboswellic acid by Bishnoi M1, Patil CS, Kumar A, Kulkarni SK.(PubMed)
(125) Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata by Peters RR1, Farias MR, Ribeiro-do-Valle RM.(PubMed)
(126) Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of thecucurbitacins fraction from Wilbrandia ebracteata by Peters RR1, Baier Krepsky P, Siqueira-Junior J, da Silva Rocha JC, Marques Bezerra M, de Albuquerque Ribeiro R, de Brum-Fernandes AJ, Rocha Farias M,Castro da Rocha FA, Ribeiro-do-Valle RM(PubMed)