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Wednesday, 17 September 2014

Endometriosis: The Effects of Vitamin B3(revised edition with references)

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com
Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.

Vitamin B3 , also known as niacin, is a water-soluble vitamin. Besides being usedto treat pellagra caused by dietary lack of vitamin B3 and protein, it also has been known to be effective in treating endometriosis because women with endometriosis are found to have vitamin B3 deficiency. It has a chemical compound formula of C6H5NO2.

1. Hormone synthesis(2)
Vitamin B3 is found to help the manufacturing of hormones such as cortisone and the sex hormones such as  estrogen, progesterone, testosterone, and other steroid hormones in a woman's body. Besides helping to inhibit levels of bad estrogen that causes menstrual cramps during menstrual cycle, it also helps to balance the prostaglandin hormone which causes over-active uterine muscles(1).

2. Digestive system(3)(4)
Deficiency of vitamin B3 is generally found in women with endometriosis during menstruation. It may be caused by the inability of the digestive system in breaking down food particles. Intake of vitamin B3 helps to re-balance the hormones that cause menstrual cramps.

3. Metabolism of carbohydrates(5)(6)(7)
Besides helping to provide energy for our body in metabolism of carbohydrate through bile secretion,

4. Circulatory stimulation(7)
Vitamin B3 also helps in stimulation of the circulatory system by reducing the level of bad cholesterol (LDL) from the arteries in some people.

5. Nervous system(5)
Vitamin B3 is important for the healthy activity of the nervous system by providing the metabolism of protein and fat which are nutrients necessary for brain cells resulting in reduced symptoms of endometriosis such as depression, anxiety, and irritation.

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References
(1) Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production by Sugita K1, Ikenouchi-Sugita A, Nakayama Y, Yoshioka H, Nomura T, Sakabe J, Nakahigashi K, Kuroda E, Uematsu S, Nakamura J, Akira S, Nakamura M, Narumiya S, Miyachi Y, Tokura Y, Kabashima K.(PubMed)
(2)Leklem J. E. Vitamin B6. In: Shils M, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore: Williams & Wilkins; 1999:413–422.
(3) http://www.everydayhealth.com/digestive-health/essential-vitamins-for-digestive-health.aspx
(4) Improve your digestive health with these 3 essential vitamins January 28, 2014 by  Dr. Micozzi
(5)Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection by Chi Y1, Sauve AA.(PubMed)
(6)Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes.by Yang SJ1, Choi JM, Kim L, Park SE, Rhee EJ, Lee WY, Oh KW, Park SW, Park CY.(PubMed)

(7)Nicotinamide, a glucose-6-phosphate dehydrogenase non-competitive mixed inhibitor, modifies redox balance and lipid accumulation in 3T3-L1 cells.by Torres-Ramírez N1, Baiza-Gutman LA, García-Macedo R, Ortega-Camarillo C, Contreras-Ramos A, Medina-Navarro R, Cruz M, Ibáñez-Hernández MÁ, Díaz-Flores M.(PubMed)
(8)Niacin inhibits vascular inflammation via downregulating nuclear transcription factor-κB signaling pathway by Si Y1, Zhang Y2, Zhao J3, Guo S2, Zhai L2, Yao S1, Sang H1, Yang N2, Song G2, Gu J4, Qin S2.(PubMed)