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During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.
Biotin, one of the members of the vitamin B complex, also known as vitamin H or B7 is a co-factor in the metabolism of fatty acids, leucine, and in gluconeogenesis. It has a chemical structure formula of C10H16N2O3S. Deficiency is extremely rare, as intestinal bacteria generally produce an excess of the body's daily requirement but for what ever reason, women with endometriosis are found to have low levels of biotin.
1. Cell abnormality(1)(2)
Biotin acts as a co-factor with the other members in the vitamin B complex. It plays an important role in managing the body's cell growth(3). Without enough biotin, it causes cell growth abnormality such as the forming of perinatal cells into endometrial cell in the abdominal regions.
2. Poor blood circulation
Since biotin helps in gluconeogenesis(5), it regulates the sugar levels in the blood stream(4). Without enough levels of biotin, the level of blood sugar rises causing the thickening of blood which reduces the circulatory function and blocks the transportation of nutrients and oxygen to our body's cells. This results in an increased risk of symptoms of endometriosis.
3. Menstrual cramps(8)
Since biotin is necessary in the metabolism of fatty acids, it helps to maintain levels of prostaglandins. Deficiency of biotin causes some members in the prostaglandins family to be over-produced during the menstrual cycle leading to menstrual and endometrial cramps.
4. Respiratory problem(6)(7)
Since biotin helps to synthesize carbon dioxide, without enough biotin it causes shortness of breath in women with endometriosis.
5. Risk of heart disease(9) and stroke(10)
If the liver cannot produce enough bile to generate good cholesterol because of not enough amounts of biotin in the body, it leads to cholesterol building up in the arteries causing the thickening of the arterial wall and the blockage o circulation of blood resulting in an increased risk of heart disease and stroke.
6. Weaken function of nervous system(11)(12)
Since biotin acts as a co-factor with other vitamin B complexes in the metabolism of protein, deficiency of biotin interferes with that process. It weakens the normal functions of cells in the nervous system leading to tension of the nervous system such as anxiety, dizziness, loss of memory, and depression.
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(1) Biotin ligase tagging identifies proteins proximal to E-cadherin, including lipoma preferred partner, a regulator of epithelial cell-cell and cell-substrate adhesion by Van Itallie CM1, Tietgens AJ, Aponte A, Fredriksson K, Fanning AS, Gucek M, Anderson JM.(PubMed)
(2) Effects of biotin supplementation in the diet on insulin secretion, islet gene expression, glucose homeostasis and beta-cell proportion by Lazo de la Vega-Monroy ML1, Larrieta E, German MS, Baez-Saldana A, Fernandez-Mejia C.(PubMed)
(3) Biotin requirements for DNA damage prevention by Zempleni J1, Teixeira DC, Kuroishi T, Cordonier EL, Baier S.(PubMed)
(4) Influence of a deficiency in biotin on the activity of pyruvate carboxylase and on gluconeogenesis from [14C]pyruvates or bicarbonate in mice by Mayobre ML, Pasquier S, Favarger P, Rous S.(PubMed)
(5) Altered glucagon release in biotin deficiency by Klandorf H, Clarke BL, Brown J.(PubMed)
(6) Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts by Atamna H1, Newberry J, Erlitzki R, Schultz CS, Ames BN.(PubMed)
(7 ) [Prospective study of biotin treatment in patients with erythema due to gefitinib or erlotinib].