Herbal Calendula and wound healing

Calendula is also known as pot marigold, a annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe. It has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.

Ingredients
Beside major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.

According to the Federal University of Goiás, the ethanolic extract, the dichloromethane, and hexanic fractions from Calendula showed a positive effect in speeding up the chorioallantoic membrane and cutaneous wounds healing through its anti-inflammatory and anti bacterial activities in rat models.(1).
The exertion of angiogenesis of this herb may be not directly related to the expression of VEGF and probably associated to other pro-angiogenic factors(2). "Oral and topical application of Calendula officinalis flower extract showed a significant increase was observed in the hydroxy proline and hexosamine content in the extract-treated group compared with the untreated animals" Dr. Preethi KC, and Dr. Kuttan R.said(3).


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References
(1) Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil by Parente LM¹, Lino Júnior Rde S, Tresvenzol LM, Vinaud MC, de Paula JR, Paulo NM.(PubMed)
(2) Angiogenic activity of Calendula officinalis flowers L. in rats by Parente LM¹, Andrade MA, Brito LA, Moura VM, Miguel MP, Lino-Júnior Rde S, Tresvenzol LF, Paula JR, Paulo NM.(PubMed)
(3) Wound healing activity of flower extract of Calendula officinalis by Preethi KC¹, Kuttan R.(PubMed)