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Sunday, 27 April 2014

Cervical cancer in Vitamin B6 Points of View

Kyle J. Norton  

Epidemiological studies focusing vitamin B6 in reduced risk of cervical  cancer have produced conflict results(a)(b)(c)(d). According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of  4,020 patients. The risk of cervical cancer is higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites(e).
Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens, Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate  metabolism, brain health, and liver detoxification, etc.

Suggestions of polymorphisms in genes related to folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia, according to the study of Dr.Cardoso MA and the research team(1). In the study of Vitamin B6 status in patients with cancer of the uterine cervix, researchers found that  23-35%the patients with cervical cancer, a 23-35% are associated with deficiency of vitamin B6(2). Other in the research of serum homocysteine  and cervical cancer risk indicated a strongly and significantly predictive of invasive cervical cancer risk associated with folate, B12 and/or B6 inadequacy, or genetic polymorphisms affecting one-carbon metabolism(3). In a multiethnic case-control study for examination of the association of dietary folate and MTHFR genotype with the odds ratios (ORs) for cervical dysplasia among women identified from several clinics on Oahu, Hawaii, between 1992 and 1996 indicated that dietary intakes of folate, vitamin B(6), and vitamin B(12) were inversely related to the ORs for cervical squamous intraepithelial lesions (SILs)(4). The study at the University of Arizona, showed that folate, vitamin B12, vitamin B6, and methionine may function to prevent cervical cancer through their role in DNA methylation(5)

Taken altogether, intake of Vitamin B6 may be related to reduced risk of cervical cancer in patients with deficiency and through its function in in DNA methylation. Over doses may induced the symptoms of difficulty coordinating movement, numbness, sensory changes, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies. As always, all articles written by Kyle J. Norton are for information & education only, please consult your Doctor & Related field specialist before applying



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References
(a) Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12 by Hernandez BY1, McDuffie K, Wilkens LR, Kamemoto L, Goodman MT.(PubMed)
(b) A case control study of nutritional factors and cervical dysplasia by Liu T1, Soong SJ, Wilson NP, Craig CB, Cole P, Macaluso M, Butterworth CE Jr.(PubMed)
(c) [Chemoprevention of cervical cancer--intervention study of cervical precancerous lesions by retinamide II and riboflavin].[Article in Chinese] byChen RD.(PubMed)
(d) Epidemiologic studies of vitamins and cancer of the lung, esophagus, and cervix by Ziegler RG.(PubMed)
(a) Cerical cancer (Amerrican cancer society)
(1) Nutritional and genetic inefficiencies in one-carbon metabolism and cervical cancer risk. by Ziegler RG1, Weinstein SJ, Fears TR.(PubMed)
(2) Vitamin B6 status in patients with cancer of the uterine cervix by Ramaswamy PG, Natarajan R.(PubMed)
(3) Elevated serum homocysteine levels and increased risk of invasive cervical cancer in US women by Weinstein SJ1, Ziegler RG, Selhub J, Fears TR, Strickler HD, Brinton LA, Hamman RF, Levine RS, Mallin K, Stolley PD.(PubMed)
(4) Association of methylenetetrahydrofolate reductase polymorphism C677T and dietary folate with the risk of cervical dysplasia by Goodman MT1, McDuffie K, Hernandez B, Wilkens LR, Bertram CC, Killeen J, Le Marchand L, Selhub J, Murphy S, Donlon TA.(PubMed)
(5) Human papillomavirus persistence and nutrients involved in the methylation pathway among a cohort of young women by Sedjo RL1, Inserra P, Abrahamsen M, Harris RB, Roe DJ, Baldwin S, Giuliano AR.(PubMed)