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Wednesday, 18 December 2013

Women's Health and Phytochemical Capsaicins

Phytochemicals Capsaicin can be found abundant in chili peppers, which are genus Capsicum, belonging to the family Solanaceae and has been used in herbal medicine to relieve muscle and arthritic pain over thousand of year. It is type of an irritant which can cause burning sensation of burning in any tissue if comes to contact, effecting mammals, excluding bird. According to the study of Health benefits of herbs and spices: the past, the present, the future. by Tapsell LC, Hemphill I, Cobiac L, Patch CS, Sullivan DR, Fenech M, Roodenrys S, Keogh JB, Clifton PM, Williams PG, Fazio VA, Inge KE. from the Source of National Centre of Excellence in Functional Foods, University of Wollongong, NSW, posted in US National Library of Medicine National Institutes of Health, researchers found that these developments are well underway through evidence-based frameworks for substantiating health claims related to foods. At present, recommendations are warranted to support the consumption of foods rich in bioactive components, such as herbs and spices. With time, we can expect to see a greater body of scientific evidence supporting the benefits of herbs and spices in the overall maintenance of health and protection from disease.

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B. The effects of Phytochemicals - Capsaicin in Women's health 1. Female reproduction function
In a study of Fifteen 21-day-old female Sprague-Dawley rats were divided randomly into three groups. The first group received no treatment, the second group received 0.5 mg/kg/day CAP dissolved in the vehicle, and the third group was treated with the vehicle only, conducted by University of Uludag, posted in PubMed, researchers found that CAP may lead to release of NO either directly from nerves or indirectly by evoking release from other cells via the action of neuropeptides that are released from afferent terminals and are involved in regulating female reproductive function.

2. Weight loss
Capsiate, a non-pungent capsaicin analog is considered as one of the best know chemical compounds of which can suppress body fat accumulation and reduce body weight by enhancing of energy expenditure. In a study of "Capsiate, a non-pungent capsaicin analog, reduces body fat without weight rebound like swimming exercise in mice" by Haramizu S, Kawabata F, Ohnuki K, Inoue N, Watanabe T, Yazawa S, Fushiki T., posted in PubMed, researchers found that the abdominal adipose tissue weight in capsiate and exercise groups was significantly lower than that of control group. These results indicate that suppressing body fat accumulation by capsiate intake is beneficial for maintaining an ideal body weight as exercise.

3. Breast cancer
Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8. In a study of "Capsaicin may induce breast cancer cell death through apoptosis-inducing factor involving mitochondrial dysfunction" by Chang HC, Chen ST, Chien SY, Kuo SJ, Tsai HT, Chen DR., posted in PubMed, researchers wrote that capsaicin inhibited breast cancer cell growth through inducing cell apoptosis and cell cycle arrest in the S phase. This apoptotic effect could be induced through the mitochondrial pathway, and PARP-1 subsequently cleaved by activation of caspase-7. The application of capsaicin in clinical therapy could be useful for breast cancer patients.

4. Regulating reproductive function
In a study of Fifteen 21-day-old female Sprague-Dawley rats were divided randomly into three groups. The first group received no treatment, the second group received 0.5 mg/kg/day CAP dissolved in the vehicle, and the third group was treated with the vehicle only, conducted by Faculty of Veterinary Medicine, University of Uludag, posted in PubMed, researchers found that
CAP may lead to release of NO either directly from nerves or indirectly by evoking release from other cells via the action of neuropeptides that are released from afferent terminals and are involved in regulating female reproductive function.

5. Endometriotic cells
According to the study of "Capsaicin inhibits proliferation of endometriotic cells in vitro" by Wu Y, Starzinski-Powitz A, Guo SW, posted in PubMed, researchers found that treatment of immortalized stromal-like and epithelial-like endometriotic cells with capsaicin resulted in inhibition of proliferation in a concentration-dependent manner. In addition, endometriotic cells are more sensitive to capsaicin treatment than immortalized endometrial cells, suggesting that capsaicin may be an admissible drug candidate for treating endometriosis.

6. Etc.
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