In general assumption that high intake of trans fatty acids and
saturated fatty acids (SFAs) is known to increase the risk of coronary
heart disease, but whether the effects of diets enriched in various
fatty acids on postprandial insulinemia and fasting serum levels of
lipids and lipoproteins in obese patients with NIDDM is to be
determined.
In the study of 16 obese NIDDM patients in a free-living
outpatient regimen, after a run-in period, the patients received three
different isocaloric diets for 6 weeks using a randomized crossover
design. The patients were instructed to keep the energy intake from
carbohydrate and protein constant at 50 and 20 E% (percent of energy
intake), respectively, on all three diets. The fat composition of the
diets differed: saturated fat (SAT) diet (20 E% SFAs, 5 E%
polyunsaturated fatty acids [PUFAs], and 5 E% monounsaturated fatty
acids [MUFAs]) versus cis monounsaturated fatty acid (CMUFA) diet (20 E%
cis-MUFAs, 5 E% PUFAs, and 5 E% SFAs) versus trans monounsaturated
fatty acid (TMUFA) diet (20 E% trans-MUFAs, 5 E% PUFAs, and 5 E% SFAs,
the group filed the result that in the presence of unchanged glycemia,
both dietary trans fatty acids and SFAs induce an increase in
postprandial insulinemia in obese patients with NIDDM.
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(1)
"Intake of a diet high in trans monounsaturated fatty acids or
saturated fatty acids. Effects on postprandial insulinemia and glycemia
in obese patients with NIDDM" by Christiansen E, Schnider S, Palmvig B, Tauber-Lassen E, Pedersen O., posted in PubMed
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