Ghrelin is a hormone produced
by the stomach and pancreas with the function of stimulating hunger to
protect against the fat loss as a result of thousand years in protecting
the survival of human species. Its levels increase before meals and
decrease after meals. As to its unique activity, many researchers have
tried to find a way to block the stimulation of this hormone for weight
loss.
In the study of (a) changes in ghrelin and peptide YY (PYY) concentrations during a weight reduction programme and (b) baseline ghrelin and PYY levels during a weight reduction programme with 15 normal-weight
teenagers and 32 severely obese adolescents (BMI z score = 4.1),
researchers found that obese teenagers had lower ghrelin and PYY
concentrations than normal-weight
adolescents (P < 0.05). Moreover, they showed significantly higher
leptin, insulin levels and homeostasis model assessment (HOMA) (P <
0.0001).). During the lifestyle modification, there was a significant
decrease in body weight
among obese teenagers, associated with an increase in ghrelin
(apparent from month 6; P < 0.05), a decrease in leptin (from month
3; P < 0.05) and a decrease in insulin and HOMA (from month 3; P
< 0.0001), without any significant change in PYY.
Researchers
concluded that In adolescents with severe obesity, a long-term
combination of supervised aerobic exercises and a balanced diet led to weight
reduction and increased ghrelin concentrations, without any change in
PYY concentrations. Moreover, baseline PYY concentrations might be
considered as predictors of weight loss. (1)
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(1) "Ghrelin and PYY levels in adolescents with severe obesity: effects of weight loss induced by long-term exercise training and modified food habits." by Gueugnon C, Mougin F, Nguyen NU, Bouhaddi M, Nicolet-Guénat M, Dumoulin G. posted in PubMed
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