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Tuesday, 3 December 2013

Colitis - Treatments in Herbal medicine

Colitis is defined as a condition of inflammation of the large intestine, including the colon, caecum and rectum.
Treatments

C. In herbal medicine perspective
1. Ambrotose complex and Advanced Ambrotose (aloe vera gel, arabinogalactan, fucoidan, and rice starch)
In the study to test the efficacy of Plant-derived polysaccharide supplements in inhibiting dextran sulfate sodium-induced colitis in the rat, conducted by the Eurofins Product Safety Laboratories, indicated that Ambrotose complex and Advanced Ambrotose are dietary supplements that include aloe vera gel, arabinogalactan, fucoidan, and rice starch, all of which have shown anti- inflammatory activity(118).

2. Flax seed
People use flaxseed for many conditions related to the gastrointestinal (GI) tract, including ongoing constipation, colon damage due to overuse of laxatives, diarrhea, inflammation of the lining of the large intestine (diverticulitis), irritable bowel syndrome (IBS) or irritable colon, sores in the lining of the large intestine (ulcerative colitis), inflammation of the lining of the stomach (gastritis), and inflammation of the small intestine (enteritis)(119).

3. Boswellia
In the study to evaluate the antioxidant effect of an extract of the plant Boswellia serrata in an experimental model of acute ulcerative colitis induced by administration of acetic acid (AA) in rats, found that the extract of B. serrata has active antioxidant substances that exert protective effects in acute experimental colitis(120).

4. Peppermint Oil
Peppermint oil is the major constituent of several over-the-counter remedies for symptoms of irritable bowel syndrome (IBS). According to the study by Postgraduate Medical School, University of Exeter, found that 8 randomized, controlled trials were located. Collectively they indicate that peppermint oil could be efficacious for symptom relief in IBS. A metaanalysis of five placebo-controlled, double blind trials seems to support this notion(121).

5. Ginger
Ginger is a commonly used spice with anti-inflammatory potential. In the study to investigate the therapeutic effects of ginger and its component zingerone in mice with 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis, showed that nuclear factor-κB (NF-κB) and interleukin-1β (IL-1β) were key molecules involved in the expression of ginger- and zingerone-affected genes. Ex vivo imaging and immunohistochemical staining further verified that ginger and zingerone suppressed TNBS-induced NF-κB activation and IL-1β protein level in the colon. In conclusion, ginger improved TNBS-induced colitis via modulation of NF-κB activity and IL-1β signalling pathway. Moreover, zingerone might be the active component of ginger responsible for the amelioration of colitis induced by TNBS(122).

6. Etc.
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Sources
(118) http://www.ncbi.nlm.nih.gov/pubmed/19513840
(119) http://www.nlm.nih.gov/medlineplus/druginfo/natural/991.html
(120) http://www.ncbi.nlm.nih.gov/pubmed/22451119
(121) http://www.ncbi.nlm.nih.gov/pubmed/9672344
(122) http://www.ncbi.nlm.nih.gov/pubmed/23017409