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Tuesday, 3 December 2013

Cirrhosis - Treatments of Medication causes of cirrhosis

Cirrhosis is defined as a condition of irreversible scarring liver as a result of liver tissue by fibrosis due to final phase of chronic liver diseases of that can lead to poor function of the liver and liver failure. According to the statistics, Number of discharges with chronic liver disease or cirrhosis as the first-listed diagnosis: 101,000 in 2009 and Deaths per 100,000 population: 10.3 in 2010(a). Hepatitis B infection cause of the disease is very prevalent in South-East Asia.
Treatments
A. Treatments of cirrhosis depend not on the underline causes and stage of the diseases 
Medication causes of cirrhosis
According to the study by the Seoul National University College of Medicine, anti-tuberculosis (TB) drug-induced liver injury (DILI) in patients with chronic liver disease including cirrhosis, but the drugs may be safely used in the patients with chronic liver disease including compensated cirrhosis if number of hepatotoxic drugs used is adjusted appropriately(85). In other study by University "Magna Græcia" of Catanzaro, there is a case of a male patient who developed severe drug-induced hepatotoxicity during the treatment with Cyproterone acetate (CPA). The case, presenting sub-acute hepatitis, was characterized by a rapid evolution of cirrhosis and a protracted activity during the period of a few months despite the treatment withdrawal and an apparent benefits of corticosteroids, suggesting their indication in life threatening cases(86). Please consult your doctor for replacement medication.
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Sources
(a) http://www.cdc.gov/nchs/fastats/liverdis.htm
(85) http://www.ncbi.nlm.nih.gov/pubmed/20670648