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Thursday, 28 November 2013

Thyroid disease: Hypothyroidism – Antioxidants and phytochemical to prevent Hypothyroidism

Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones. Hypothyroidism is a condition in which the thyroid gland is under active and produces very little thyroid hormones.
E. Prevention
E.2. Antioxidants and phytochemical to prevent Hypothyroidism
1. Iodine
There is a report of the Japanese experience may indicate a protective effect against breast cancer for an iodine rich seaweed containing diet. Similarly thyroid autoimmunity may also be associated with improved prognosis. Whether this phenomenon is breast specific and its possible relationship to iodine or selenium status awaits resolution(50).
2. Resveratrol
In the study of resveratrol, the main ingredient found in skin and seed of grape and its impact on aging and thyroid function, showed that resveratrol is believed to regulate several biological processes, mainly metabolism and aging, by modulating the mammalian silent information regulator 1 (SIRT1) of the sirtuin family. Resveratrol may arrest, among various tumors, cell growth in both papillary and follicular thyroid cancer by activation of the mitogen-activated protein kinase (MAPK) signal transduction pathway as well as increase of p53 and its phosphorylation. Finally, resveratrol also influences thyroid function by enhancing iodide trapping and, by increasing TSH secretion via activation of sirtuins and the phosphatidylinositol- 4-phosphate 5 kinase γ (PIP5Kγ) pathway, positively affects metabolism(51)
3. Polyphenolic flavonoids
In the comparison of the efficacy of polyphenolic flavonoids found in black and green tea in thyroid function, showed that green tea extract at 2.5 g% and 5.0 g% doses and black tea extract only at 5.0 g% dose have the potential to alter the thyroid gland physiology and architecture, that is, enlargement of thyroid gland as well as hypertrophy and/or hyperplasia of the thyroid follicles and inhibition of the activity of thyroid peroxidase and 5(‘)-deiodinase I with elevated thyroidal Na+, K+-ATPase activity along with significant decrease in serum T3 and T4, and a parallel increase in serum thyroid stimulating hormone (TSH)(52)
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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/17933284
(50) http://www.ncbi.nlm.nih.gov/pubmed/14757962
(51) http://www.ncbi.nlm.nih.gov/pubmed/21946130
(52) http://www.ncbi.nlm.nih.gov/pubmed/20801949
(52a) http://www.ncbi.nlm.nih.gov/pubmed/23801264