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Thursday, 28 November 2013

Thyroid disease: Hypothyroidism – Treatments In conventional medicine perspective

Thyroid is one of the largest endocrine glands found in the neck, below the Adam’s Apple with the function of regulating the body use of energy, make of proteins by producing its hormones as a result of the stimulation of thyroid-stimulating hormone (TSH) produced by the anterior pituitary.
Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones. Hypothyroidism is a condition in which the thyroid gland is under active and produces very little thyroid hormones
F. Treatments
F.1. In conventional medicine perspective  
  Patients with hypothyroidism are treated by Thyroid hormone therapy with doses depending to the stage and types of the diseases
In patients with overt hypothyroidism defined as low FT4 and elevated TSH or TSH > 10 mU/L a replacement with levothyroxine is clearly indicated. In patients with subclinical hypothyroidism defined as a TSH between 4 and 10 mU/L and normal FT4, the treatment with Levothyroxine depends on the underlying disease and symptoms. Levothyroxine is a prohormone with is activated by deiodination in the organs to triiodothyronine, according to the study by Medizinische Klinik IV der Universität München(52a).
Standard therapy for patients with primary hypothyroidism is replacement with synthetic thyroxine, which undergoes peripheral conversion to triiodothyronine, the active form of thyroid hormone. According to the study by the University College Dublin, in a randomized, double-blind, placebo-controlled trial conducted from May 2000 to February 2002 at a military treatment facility that serves active duty and retired military personnel and their family members, indicated that compared with levothyroxine alone, treatment of primary hypothyroidism with combination levothyroxine plus liothyronine demonstrated no beneficial changes in body weight, serum lipid levels, hypothyroid symptoms as measured by a HRQL questionnaire, and standard measures of cognitive performance(53). Other in the study to examine the efficacy of combination therapy with levothyroxine and liothyronine in improvement of general health, psychological problems, and metabolic status in primary hypothyroidism, showed that Psychosocial scores, body weight, heart rate, blood pressure, and lipid profile in the two groups remained constant(54).
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Sources(a) http://www.ncbi.nlm.nih.gov/pubmed/17933284 
(52a) http://www.ncbi.nlm.nih.gov/pubmed/23801264
(53) http://www.ncbi.nlm.nih.gov/pubmed/14665656
(54) http://www.ncbi.nlm.nih.gov/pubmed/19701833