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Thursday, 28 November 2013

Thyroid disease: Hypothyroidism – Treatments In traditional Chinese medicine perspective

Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones. Hypothyroidism is a condition in which the thyroid gland is under active and produces very little thyroid hormones.
F. Treatments
F.3. In traditional Chinese medicine perspective
1. Herbs tonify kidney-yang
According to the study by the Guangzhou University of TCM, in the study of The rectal temperature (Tr) and heart rate (HR) of three groups of New Zealand white rabbits, indicated that the Tr and HR in G1 were decreased, and the circadian rhythms of the Tr and HR disordered significantly, while these changes in G2 were corrected obviously(59).
2. Yang tonifying herbs
According to the study by the Department of Medicine, University of Western Australia, In a randomly divided into three groups study, each contained six rabbits, i.e. thyroidectomized and untreated rabbits (group 1), thyroidectomized rabbits treated by the Yang tonifying herbs (group 2) and sham thyroidectomized rabbits as controls (group 3), indiaced that the Bmax, T4, T3 and HR in group 1 were lower significantly than that in group 3 (P < 0.01-0.001), but the change of Kd in group 1 was not significant; the deviation of the indices from the normal value in group 2 was less remarkably than in group 1 other than T4(60).
3. Baji Zibugao
In the study of the effect of Baji Zibugao (BJZBG, a medicinal plaster mainly consisting of Radix Morindae Officinalis) on the endocrine functions of hypothyroid rabbits in three groups of rabbits: total thyroidectomized and untreated (group I), total thyroidectomized and treated with BJZBG (group II) and controls (group III). to determine the serum levels of thyroxine (T4), triiodothyronine (T3), cAMP, cGMP and corticosteron, showed that (1) The serum level of T4 in group I and II after operation was significantly lower than that before operation (P < 0.005), and the serum level of T3 in group I was also lower than that before operation (P 0.05); (2) The serum cAMP level in group I after operation decreased and the cGMP level increased (P 0.05), (3) The change of serum corticosterone level in group I or II after operation was not remarkable (P > 0.05)(61).
4. Cnidium monnieri (She Chuang Zi)
In the study the effects of total coumarins, essential oil and water extracts of Cnidium monnieri on plasma prostaglandin (PGE2 and PGF2 alpha) and cyclic nucleotide levels in rats of Kidney-Yang insufficiency with 55 rats divided randomly into 5 groups (Group I was administered orally with saline (normal group), group II was injected with intraperitonally hydrocortison acetate to induce Kidney-Yang insufficiency (control group), group III, group IV and group V (experimental groups) were injected with hydrocortison acetate, the same as group II, and administered orally with the total coumarins, essential oil and water extracts of Fructus Cnidii respectively) showed that the levels of plasma PGE2, PG2 alpha and plasma cAMP, cGMP were measured. In group II, in comparing with those of group I, the levels of plasma PGE2, and PGF2 alpha decreased significantly (P < 0.01), and the value of cAMP/cGMP also lowered obviously (P < 0.01) due to the significant reduction of cAMP and insignificant change of cGMP. In group III and group V, the above-mentioned indices changed significantly (P < 0.01 or 0.05) compared with those of group II, and after treatment it normalized basically in comparing with those of group I. In group IV, those indices didn't change regularly and apparently as group III and group V did, compared with group II, and could not normalize satisfactorily. It is suggested that the coumarins in the fruit of Cnidium monnieri are probably the effective ingredients to invigorate Kidney and strengthen Yang, while the efficacy of essential oil remained unconfirmed(62).
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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/17933284
(59) http://www.ncbi.nlm.nih.gov/pubmed/9208562
(60) http://www.ncbi.nlm.nih.gov/pubmed/9533431
(61) http://www.ncbi.nlm.nih.gov/pubmed/7744389
(62) http://www.ncbi.nlm.nih.gov/pubmed/8392879