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Saturday, 30 November 2013

Shingles - The Causes and risk factors

I. Shingles also known as herpes zoster or zona is defined as a viral disease with condition of a painful, blistering skin rash on one side of the body of  that can continue to be painful even after the rash have long disappeared(1), as a result of varicella-zoster viral causes of a nerve and skin inflammation.
Causes and risk factors
A, Risk factors
Although shingles can occur in anyone exposed to the varicella-zoster virus, people with
Advanced age and A weakened immune system are at increased risk of shingles and post
1. Advanced age
In the sane above study, Dr. Goh CL, and Dr. Khoo L. at the Institute of Dermatology, National Skin Center also said that pain was experienced by almost all (95%) patients during the course of their disease. It tended to be more severe in older patients. Burning (26%), stabbing (15%), and shooting (15%) pain were the most common types experienced. Post-herpetic neuralgia was significantly more common in older patients.(3)

2. Weakened immune system
Newborns, pregnant women, those over 50, and those with a weakened immune system (from another disease like HIV or cancer, for example), are more likely to be susceptible to the Varicella-Zoster virus as well as complications from either the Chicken Pox or Shingles.(5). Other report that Children infrequently are afflicted with herpes zoster (HZ). Activation of latent varicella-zoster virus (VZV) in a partially immune host results in HZ. Herpes zoster in children can be benign or with varied severity, especially in cases associated with malignancy. Because of its rarity, we report widespread multisegmental HZ primarily presenting on the right side of the body and abdomen in a 6-year-old immunocompetent girl.(6)

3. Etc.

B. Causes 
Causes of Shingles is as a result of a nerve and skin inflammation with zoster virus (VZV). After having chickenpox, the virus lives dormant in the nervous system and is never fully cleared from the body. Under certain circumstances, such as weakened immune system, the virus travels up the nerve roots to the area of skin supplied by those specific nerve roots.
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Sources
(3) http://www.ncbi.nlm.nih.gov/pubmed/9352407
(4) http://www.uveitissociety.org/pages/diseases/hzo.pdf
(5) http://blog.colloidsforlife.com/health-conditions/shingles-symptoms-triggered-by-a-weak-immune-system/
(6) http://www.ncbi.nlm.nih.gov/pubmed/22439309