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Thursday, 28 November 2013

Pulmonary vascular disease – Pulmonary veno-occlusive disease – The Complications

Pulmonary vascular disease is defined as a condition of blood flow to the lung’s artery is blocked suddenly due to a blood clot somewhere in the body, including pulmonary embolism, chronic thromboembolic disease, pulmonary arterial hypertension, pulmonary veno-occlusive disease, pulmonary arteriovenous malformations, pulmonary edema, etc.
Pulmonary veno-occlusive disease
Pulmonary veno-occlusive disease (PVOD) is an extremely rare form of pulmonary hypertension, affecting mostly in children and young adults as a result of a progressive obstruction of small pulmonary veins that leads to elevation in pulmonary vascular resistance and right ventricular failure.
A. Complications
1. Pulmonary vascular resistance, right heart failure and premature death
PVOD is characterised by progressive obstruction of small pulmonary veins and venules that leads to increased pulmonary vascular resistance, right heart failure and premature death, according to the study by université Paris-Sud, 94276 Kremlin-Bicêtre(19).
2. Occult alveolar haemorrhage
Occult alveolar haemorrhage is a common feature of pulmonary veno-occlusive disease. Detecting occult alveolar haemorrhage may be of interest in the diagnostic approach of pulmonary veno-occlusive disease, according to the study by Université Paris-Sud, Clamart(20).
3. Other complications
The most frequent CT-findings in pulmonary veno-occlusive disease were the following: ground glass opacity with poorly defined nodular opacities (73%), septal lines (93%), and adenopathy (80%). Pericardial (60%) and pleural effusions (27%) were also noted. Other parenchymal findings were unusual, according to the study by Hôpitaux de Paris, Université Paris Sud(21).
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Sources
(19) http://www.ncbi.nlm.nih.gov/pubmed/21211937
(20) http://www.ncbi.nlm.nih.gov/pubmed/16387942
(21) http://www.ncbi.nlm.nih.gov/pubmed/15022986