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Sunday, 24 November 2013

Polymalagia Arthritis Treatments in Traditional Chinese Medicine

Polymalagia Arthritis Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which cause pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdleas a result of the presence of a synovitis in proximal joints and periarticular structures, causing musculoskeletal symptoms in PMR.
In traditional Chinese medicine perspective
The aims of the Chinese herbal medicine formula is to enhance the immune system and promote kidney’s Qi.
 Du huo Ji Sheng Tang (DHJST)
a. In the study of Action Mechanisms of Du-Huo-Ji-Sheng-Tang on Cartilage Degradation in a Rabbit Model of Osteoarthritis, Dr. Chao-Wei Chen and the research team at the Shanghai Municipal Hospital of Traditional Chinese Medicine, showed that at the end of the sixth week after surgery, there was a significantly histological degeneration in the control group compared with the normal group. In the control group, the mean score for histological degeneration were further increases at 10th week, and there was a significantly lower mean score for histological degeneration in the DHJST group compared with the control group. To research the potential mechanism, the expression level of VEGF and HIF-1α were detected. The expression of VEGF mRNA and HIF-1α mRNA are low in normal group, while the activities increase gradually in the control group. However, compared to that of the same time point model group, activity of VEGF and HIF-1α decreased significantly in DHJST group. In conclusion, DHJST exerts significant therapeutic effect on osteoarthritis rabbits, and mechanisms are associated with inhibition of VEGF and HIF-1α expression(57).
b. Ingredients
1. Du Huo (Radix Angelicae Pubescentis)       
2. Chuan Xiong (Rhizoma  Chuanxiong)      
3. Sang Ji Sheng (Herba Taxilli)           
4. Ren Shen (Radix  et Rhizoma Ginseng)      
5. Du Zhong (Cortex Eucommiae)         
6. Gan Cao (Rx et Rz Glycyrrhizae)       
7. Niu Xi (Radix Cyathulae)            
8. Dang Gui (Radix Angelicae Sinensis)      
9. Xi Xin (Radix et Rhizoma Asari)          
10. Bai Shao (Radix Paeoniae Alba)       
11. Qin Jiao (Radix Gentianae Macrophyllae)          
12. Sheng Di Huang (Radix Rehmanniae)       
13. Fu Ling (Poriae)                  
14. Gui Xin (Cortex Rasus Cinnamomi)            
15. Fang Feng (Radix Saposhnikoviae)(56)

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Sources
(56) http://btcm.ehrenwerks.com/index.php?main_page=product_info&cPath=28_29&products_id=1938
(57) http://www.ncbi.nlm.nih.gov/pubmed/17848800