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Sunday, 24 November 2013

Pleural disease – Pleural effusion Treatments Caused by Systemic diseases

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
B. Pleural effusion
It is a condition of collection of fluid within the pleural cavity as a result of heart failure, bleeding (hemothorax), infections, excessive or decreased fluid volume, etc.
B.6. Treatments
Despite the low incidence (around 1%) of pleural effusions caused by systemic diseases, more often connective tissue diseases, such as rheumatoid arthritis or systemic lupus erythematosus.
Intra thoracic administration of cisplatin and sodium thiosulfate
In the study to to examine the pharmacokinetics and side effects of CDDP of Twenty-eight patients with malignant pleural effusion received instillation of cisplatin (CDDP) into the pleural cavity Thirteen patients received high-dose CDDP (120 mg/m2-160 mg/m2) in combination with sodium thiosulfate (STS), while 15 others received CDDP alone (80 mg/m2), found that malignant pleural effusion could be effectively treated by the instillation of CDDP 80 mg/m2 into the pleural cavity(104).

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Sources
(104) http://www.ncbi.nlm.nih.gov/pubmed/3196043