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Sunday, 24 November 2013

Pleural disease – Pleural effusion Treatments in traditional Chinese medicine perspective

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
B. Pleural effusion
It is a condition of collection of fluid within the pleural cavity as a result of heart failure, bleeding (hemothorax), infections, excessive or decreased fluid volume, etc.
B.6. Treatments
B.6.3. Treatments in traditional Chinese medicine perspective
1. Volatile oil of Centipeda minima
According to the study by the Affiliated Hospital of Guiyang Medical College, VOCM has a protective effect on acute pleural effusion in rats induced by an intrapleural injection(109)
2. Angelicae decursiva, Poncirus trifoliata and Polygonatum odoratum
Betaine, coumarin, hesperidin and kaempferol are the components derived from Lycium chinense, Angelicae decursiva, Poncirus trifoliata and Polygonatum odoratum, respectively. According to the study by the Chungnam National University, (i) Coumarin and kaempferol did not affect mucin release significantly; (ii) Betaine and hesperidin increased mucin release at the highest concentration; (iii) Poly-L-lysine inhibited and adenosine triphosphate increased mucin release. We conclude that betaine and hesperidin can increase mucin release by direct acting on airway mucin-secreting cells and suggest these agents be further studied for the possible use as mild expectorants during the treatment of chronic airway diseases(110).
3. TCM herbal granules
In the study of a patient with unilateral pleural effusion secondary to congestive heart failure with traditional Chinese herbal formulas treated with TCM herbal granules including Shengmaisan, Xiebaisan, and Tinglizi, 3 times a day for 4 weeks, showed that TCM herbal formulas could play an important role in preventing the progression of unilateral pleural effusion secondary to CHF, in case of poor response to conservative treatment. Additional studies about the mechanism of action of the medication involved are warranted(111).
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(109) http://www.ncbi.nlm.nih.gov/pubmed/16201699
(110) http://www.ncbi.nlm.nih.gov/pubmed/15162365
(111) http://www.ncbi.nlm.nih.gov/pubmed/?term=TCM+in+pleural+effeusion