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Sunday, 24 November 2013

Pleural disease – Phytochemicals and pleural effusion

The pleura is a thin tissue covered by a layer of cells (mesothelial cells) that surrounds the lungs and lines the inside of the chest wall.
B. Pleural effusion
It is a condition of collection of fluid within the pleural cavity as a result of heart failure, bleeding (hemothorax), infections, excessive or decreased fluid volume, etc.
B.5. Preventions
2. Phytochemicals to prevent pleural effusion
a. Epigallo-catechin-galleate (EGCG)
According to the study by the Harvard Medical School, Boston, EGCG abundantly in green tea, has great potential in ameliorating the development of obliterative airway disease(61).
b. Catechin polyphenols (GTPs)
Other study indicated that oral green tea catechin polyphenols (GTPs) attenuates IH-induced spatial learning deficits and mitigates IH-induced oxidative stress through multiple beneficial effects on oxidant pathways(62).
c. Curcumin (diferuloylmethane)
Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder. According to the study by, curcumin has been shown in the last two decades to be a potent immunomodulatory agent that can modulate the activation of T cells, B cells, macrophages, neutrophils, natural killer cells, and dendritic cells. Curcumin can also downregulate the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12, and chemokines, most likely through inactivation of the transcription factor NF-kappaB. Interestingly, however, curcumin at low doses can also enhance antibody responses(63).
d. Ursolic acid, betulin
In the study to investigate whether ursolic acid, betulin and 2 kinds of sulfur-containing compounds–NAC and MESNA–affect mucin release from airway goblet cells and compared the possible activities of these agents with the inhibitory action on mucin release by PLL and the stimulatory action by ATP, showed that ursolic acid and betulin can stimulate mucin release by directly acting on airway mucin-secreting cells and suggest that these agents be further investigated for the possible use as mucoregulators in the treatment of chronic airway diseases(64).

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Sources
(61) http://www.ncbi.nlm.nih.gov/pubmed/21787235
(62) http://www.ncbi.nlm.nih.gov/pubmed/18276944
(63) http://www.ncbi.nlm.nih.gov/pubmed/17211725
(64) http://www.ncbi.nlm.nih.gov/pubmed/15643543

About Kyle J. Norton

All rights reserved. Any reproducing of this article must have the author name and all the links intact. "Let Take Care Your Health, Your Health Will Take Care You" Kyle J. Norton I have been studying natural remedies for disease prevention for over 20 years and working as a financial consultant since 1990. Master degree in Mathematics, teaching and tutoring math at colleges and universities before joining insurance industries. Part time Health, Insurance and Entertainment Article Writer.