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Monday, 25 November 2013

Osteoporosis Treatments In traditional Chinese medicine perspective

Musculoskeletal disorders (MSDs) is medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed. A major restriction of joint movement range was frequent in the shoulder but uncommon in other joints. A shoulder disorder was found in 27% of subjects, rheumatoid arthritis in 1% and osteoarthritis (OA) of the hand, hip, and knee in five, seven, and 18% of subjects, respectively. Disability was frequent: a walking distance of < 500 m was found in 60% and ADL dependency in 40% of the group. Factors related to one or both of these disability measures included female gender, hip and knee OA, impaired vision, cognitive impairment and neurological disease(a).
Osteoporosis is defined as a condition of thinning of bone and bone tissues as a result of  the loss of bone density over a long period of time.
V. Treatments
C. In traditional Chinese medicine perspective
Osteoporosis in elder is defined as one of the conditions of the drop of Kidney Jing to certain level. As we age, our kidney doesn’t have the energy to nourish the bones, and they become weak and brittle, leading to the symptoms of earaches, ringing in the ears, hearing loss, hair loss, teeth problems, knee pain and lower back pain, loss of sex drive, including osteoporosis.
1. Du-Huo-Ji-Sheng-Tang and Du Zhong (Cortex Eucommiae) 
Du-Huo-Ji-Sheng-Tang and Du Zhong (Cortex Eucommiae) were the most frequently prescribed herbal formula and single herb, respectively, for the treatment of osteoporosis, according to the study by the
Department for Traditional Chinese Medicine, Chang Gung Memorial Hospital(47)
2.  Zuogui Pill
In the study to reveal the mechanism of Zuogui Pill (see text) in treatment of glucocorticoid-induced osteoporosis from the angle of the Wnt signal transduction pathway and to provide further experimental evidence for expounding the scientific connotation of “the kidney dominating the bones” in TCM, found that Zuogui Pill can prevent and treat glucocorticoid-induced osteoporosis in rats by up-regulating the expression of the key signal molecules Wnt1, LRP-5 and beta-catenin in Wnt signal transduction pathway(48).
3. Embedding thread at Shenshu (BL 23)
In the study to observe the clinical effect of embedding thread at Shenshu (BL 23) for preventing and treating primary osteoporosis, found that BMDs of hip and lumbar vertebrae were both increased in the embedding thread group, and the BMDs of femoral neck and femoral trochanter in this group were significantly higher than those in the medication group (both P < 0.05). The rate of bone fracture during 5 years after treatment was 2.1% (1/48) in the embedding thread group, which was significantly lower than 18.2% (4/22) in the medication group (P < 0 05)(49).
4. Shaoyang Meridians 
In the review to explore the theory of “Shaoyang Meridians being in charge of the bone” in Huangdi’s Internal Classic, which has been buried for long time, indicated that the theory of “Shaoyang Meridians being in charge of the bone” possibly first in the world recognizes osteoporosis being a general bony disease, and articulates that the Foot-Shaoyang Meradians can modulate bony strength under physiological and pathological conditions, and treat osteoporosis which mainly manifests as ostealgia and easy fracture(50).
5. Kidney-replenishing herbs (KRH)
In the study to investigate the effect of Kidney-replenishing herbs (KRH) on ovarian function of experimental rats with dexamethasone-induced osteoporosis (OP), showed that KRH could elevate the level of GH, LH, FSH, E2 and P, increase the weight and improve the histomorphologic features of ovary and uterus in OP rats(51).
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Sources

(47) http://www.ncbi.nlm.nih.gov/pubmed/23093986
(48) http://www.ncbi.nlm.nih.gov/pubmed/21977807 
(49) http://www.ncbi.nlm.nih.gov/pubmed/20568431
(50) http://www.ncbi.nlm.nih.gov/pubmed/18630551 
(51) http://www.ncbi.nlm.nih.gov/pubmed/11783338