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Monday, 25 November 2013

Osteoarthritis - Antioxidants and Osteoarthritis

Osteoarthritis (OA), a form of arthritis, is defined as a condition of
as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone.
1. Immune system and functioning
Free Radicals play an important role in the function of the Immune System. The immune systen produce free radicals to kill foreign microbes, but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals that stimulate the formation of more free radicals, leading to even more damage, until they are brought to stop.
a. Vitamin A
vitamin A plays an essential roles in enhancing a broad range of immune processes, including lymphocyte activation and proliferation, T-helper-cell differentiation, the production of specific antibody isotypes and regulation of the immune response.
b. Vitamin C
Researchers found that vitamin C raised the concentration in the blood of immunoglobulin A, M that promotes the ability of antibodies and phagocytic cells to clear pathogens.
c. Vitamin E
In aged mice study showed that Vitamin E beside increased both cell-dividing and IL-producing capacities of naive T cells it also enhances the immune functions in association with significant improvement in resistance to influenza infection.
d. Zinc
Zinc, as a antioxidant is essential mineral in ading immune system by enhancing the proper function of T cells which belong to a group of white blood cells known as lymphocytes, in fighting against damaging free radicals.
2. Antioxidants and osteoarthritis
a. Vitamin E and fish oil
In genetically altered mice study, researcher found that diet included fish oil plus vitamin E significantly reduce the levels of inflammation by analyzing the pro and anti-inflammatory cytokines in the blood serum.
b. Glucosamine
Since glucosamine, a compound of the simple sugar glucose and the amino acid glutamine, is a precursor for glycosaminoglycans, and they are a major component of joint cartilage. Study found that supplemental glucosamine may help to prevent cartilage degeneration and treat arthritis.
c. DLPA (dl- phenylalanine)
DLPA, a mixture of D-Phenylalanine and L-Phenylalanine, is a nutritional supplement amino acid. Researchers found that DLPA effectively reduces arthritis pain and joint inflammation in many patients.
d. Glucosamine and Methylsulfonylmethane
In a double-blind, placebo-controlled study with osteoarthritis of the knee were given a combination of glucosamine and MSM, or placebo. After 12 weeks, the results suggested combination of MSM and glucosamine may improve arthritis symptoms as compared to placebo.
3. Etc.

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