Hemipheric Migraine headache is defined as a severe and rare condition of of migraine with aura. Headache pain of a migraine may precede with temporary chemical imbalances, as the levels of the serotonin, dopamine or norepinephrine in the brain have become too low or too high, affecting transmit messages. Hemipheric Migraine headache occurs 5 to 90 minutes before the onset of the headache, but sometime through the duration of the headache.
In the investigation of the increased risk of stroke in the studied mice with familial hemiplegic migraines, Dr. Eikermann-Haerter K and the team said that (FHM1) mutations in Ca(V)2.1 voltage-gated Ca(2+) channels render the brain more vulnerable to ischemic stroke. Compared with wild-type mice, 2 FHM1 mutant mouse strains developed earlier onset of anoxic depolarization and more frequent peri-infarct depolarizations associated with rapid expansion of infarct core(5)
2. Neurovascular changes
Cerebral blood flow changes during attacks of hemiplegic migraine with prolonged aura (HMPA) longer than 24 h in patients with familial hemiplegic migraine (FHM) with a novel gene mutation, frequently are associated with hyperperfusion and middle cerebral artery vasodilation(6)
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