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Friday, 8 November 2013

Endometriosis Part VII - Prostaglandins Inhibitors- Definition, Effects,The Good, The Bad and Side Effects

During the last stage of the menstrual cycle normally a layer of endometriosis lining in the inside of the uterus is expelled, known as menstruation blood but instead some of the endometriosis tissues growing somewhere in the body causing endometriosis. Endometriosis also reacts to hormonal signals of the monthly menstrual cycle by building up tissue, breaking it, and eliminating it through the menstrual period. Sometime, during menstrual cramps, women may be given prostaglandins inhibitors helping to relief the pains. In this article, we will discuss what is prostaglandins inhibitors ?
I. Definition
prostaglandins inhibitors are men made prostaglandins hormones that help to block the production of prostaglandins from our body during menstrual cycle. Since over production of certain types of prostaglandins hormones cause over contraction of uterine muscles resulting in menstrual cramps and blocking them are benefits for women with severe period pain.
II. Effects
Prostaglandins family is one of the subgroup of icosanoid extended family. It contains prostacyclins, thromboxanes and individual prostaglandins. Prostaglandins influence the menstrual cycle in women. Any imbalance of prostaglandin will cause heavy period as well as menstrual cramps. Prostaglandins inhibitors are drugs that suppress the production of prostaglandins and thromboxanes due to its irreversible inactivation of the cyclooxygenase (COX) enzyme that causes heavy period and menstrual cramps from uterine muscle spasm.. Prostaglandins inhibitors do not help to re balance the imbalance of prostaglandins, but only helps to control the symptoms of menstrual pain.
III. The good
a) Inhibiting the natural prostaglandins in the women menstrual cycle will reduce the over active uterine and ovarian muscles that cause the abdominal pain, if endometrial implants and adhesion in the wall of the ovary.
b) The medication can be brought without prescription, such as Aspirin, Ponstan, Nurofen, etc.
c) They also help to reduce the heavy period as uterine muscles now are being controlled by the effects of the medication.
d) They are more effective in treating symptoms of menstrual cycle if taking together with other oral contraceptive pills.
e) They sometime may also correct the prostaglandins imbalance for some women.
IV. The bad
a) Most prostaglandins inhibitors only correct the symptoms while they are around. Symptoms of menstrual cycle will re appear when the medication is wire off.
b) Over taking prostaglandins inhibitor will severely damage the liver, causing variety of diseases.
c) The medication may cause gastro-intestine system problem, such as stomach pain, vomiting, nausea, constipation. Taking them with foods can reduce the above side effects.
d) Increase the risk of asthma, lupus and clotting disorders.
e) They may cause pelvic inflammatory diseases.
V. Side effects
It is advised that prostaglandins inhibitors drugs should be taken with food to prevent any problem with the gastro-intestine system. Since prostaglandins inhibitors are nonsteroidal anti-inflammatory drug, they have below side effects if overdose.
1) Nausea
2) Vomiting
3) Stomach pain
4) Micro-bleeding and ulcers
5) Abdominal cramps


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