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Friday, 29 November 2013

Cerebritis, Lupus, and Lupus Cerebritis What to avoid

Cerebritis is defined as an inflammation of the cerebrum, a structure associated with memory, speech, etc., as a result of the formation of an abscess within the brain itself, found commonly in patients with lupus.

Systemic lupus erythematosus (SLE) or Lupus is a chronic, autoimmune disease as as a result of the development of autoantibodies that attack the systems and organs in the body.researchers at the indicated that saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1β and IL-18 production.

Lupus cerebritis is a disorder of nervous system problems (an autoimmune inflammatory disorder) caused by lupus as as a result of the development of autoantibodies that attack the systems and organs in the body. It causes migraine headache, if the duration of the central nervous system involvement last for a few minutes, or causes dementia that can lead to neurological deficits as a transient attacks or permanently.
Prevention
A. What to avoid
Any thing which cause inflammation must be avoid. thyere is a report found that SLE patients and lupus-prone mice induces skin inflammation following intradermal injection into normal mice. Lupus serum depleted of IgG failed to cause skin inflammation(36). including
1. Sugar
Refined sugar with high glycemic values cause fluctuation of insulin levels and put the immune system on high alert. In the evaluation of one hundred and eleven serum samples were assayed from patients with Graves' disease, primary hypothyroidism, chronic autoimmune thyroiditis, Addison's disease, chronic autoimmune hepatitis, pernicious anemia, lupus erythematosus, and rheumatoid arthritis, together with 45 serum samples from normal subjects, conducted by Clinic of Endocrinology, University La Sapienza, showed that contrary to expectation anti-immunoglobulin antibodies are not associated with non-diabetes-related autoimmune diseases, increased humoral immunoresponsiveness to endogenous insulin appears to be related to autoimmunity in general rather than restricted to Type I diabetes.(33)

2. Saturated and trans fat
Saturated fat and trans fat  trigger and stimulate the immune system's inflammatory response. In the study of Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling, Dr. Haitao Wen, and the team indicated that High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2 diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced by the fatty acids in an HFD, and how this alters insulin signaling, is unclear. We show that the saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome(34)

3. Diary products
Diary products can cause allerdic effect that lead to the production immunoglobulin E antibodies, histamine, etc., causing immune system malfunction.

4. Process foods
In an article of Inflammatory Foods, Consider avoiding to achieve Natural remission in RA, the author wrote "often times people reduce the intake of inflammatory foods but fail to recognize all the hidden places, generally in processed foods, that these foods are being consumed. Many arthritic symptoms are triggered by allergies" (35) that can lead to inflammation.

5. Smoking and alcohol
In the assessment of whether smoking or alcohol consumption is associated with lupus erythematosus (LE), conducted by Place de l'hôpital, Dr. Boeckler P and the team showed that cigarette smoking is associated with LE, but alcohol consumption is not. The risk conferred by cigarette smoking seems highest in patients who meet fewer than 4 ACR criteria and/or who do not have antinuclear DNA antibodies(37)

6. Refined products
Refined grains pattern was positively related to sICAM-1 (P for trend = 0.007)(38)

7. Artificial ingredients
There is a report that scientists disagree about the relationships between sweeteners and lymphomas, leukemias, cancers of the bladder and brain, chronic fatigue syndrome, Parkinson's disease, Alzheimer's disease, multiple sclerosis, autism, and systemic lupus.(39)


8. Allergic effects
Allergic effect can increase the risk of the development of lupus as a result of inflammation caused by  immune system malfunction.


9. Etc.

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Sources
(33) http://www.ncbi.nlm.nih.gov/pubmed/2183533
(34) http://www.nature.com/ni/journal/v12/n5/full/ni.2022.html
(35) http://www.livingwithrheumatoidarthritis.com/Inflammatory-foods.html
(36) http://www.ncbi.nlm.nih.gov/pubmed/20483718
(37) http://www.ncbi.nlm.nih.gov/pubmed/19770440
(38) http://www.ncbi.nlm.nih.gov/pubmed/15447916
(39) http://www.ncbi.nlm.nih.gov/pubmed/18604921