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Friday, 29 November 2013

Cerebritis, Lupus, and Lupus Cerebritis Treatments in TCM Perspective

Cerebritis is defined as an inflammation of the cerebrum, a structure associated with memory, speech, etc., as a result of the formation of an abscess within the brain itself, found commonly in patients with lupus.

Systemic lupus erythematosus (SLE) or Lupus is a chronic, autoimmune disease as as a result of the development of autoantibodies that attack the systems and organs in the body.researchers at the indicated that saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1β and IL-18 production.

Lupus cerebritis is a disorder of nervous system problems (an autoimmune inflammatory disorder) caused by lupus as as a result of the development of autoantibodies that attack the systems and organs in the body. It causes migraine headache, if the duration of the central nervous system involvement last for a few minutes, or causes dementia that can lead to neurological deficits as a transient attacks or permanently.
C. In Chinese medicine perspective 
Depending to the  symptoms and differentiation together with the physical exam and appearance, etc. Systemic lupus erythematosus (SLE) can be classified as(54)
C. 1. Toxin heat invasion
1. Symptoms
Acute stage - red eruptions with a high fever, irritability
2. Formula used to treat used for all types of bleeding due to Heat and Blood Stasis. (Do not use for bleeding due to Spleen deficiency)
2.1. Xi Jiao Di Huang Tang
a. Xi Jiao (cornu rhinoceri) 3g
b. Sheng Di Huang (radix rehmanniae glutinosae) 24g
c. Shao Yao (radix paeoniae) 9g
d. Mu Dan Pi (cortex moutan radicis) 6g

2.2. Wu Wei Xiao Du Yin
a. Jin Yin Hua (honeysuckle flower) 9g
b. Pu Gong Ying (dandelion) 3.6g
c. Zi Hua Di Ding (viole) 3.6g
d. Ye Ju Hua (wild chrysanthemum flower) 3.6
e. Zi Bei Tian Kui (Begonia) 3.6g


C.2. Internal Heat due to Yin-Deficiency
1. Symptoms
Slight fever, fatigue, dry mouth, flushed face, red cheeks, nocturnal emissions, chronic sore throat, frequent urination of dark

2. Formula
Zhi Bai Di Huang Tang used to treat insufficient liver and kidney yin plus heat signs.  
2.1. Zhi Bai Di Huang Tang
a, Shu Di (Rehmannia prepared root)  (21.7%)
b. Zhi Mu (Anemarrhena root)(16.2%)
c. Huang Bai (Phellodendron bark)(16.2%) 
d. Shan Zhu Yu (Cornus fruit)(10.8%)
e. Shan Yao (Dioscoria root)(10.8%) 
f. Fu Ling (Poria cocos fungus) (8.1%) 
g. Mu Dan Pi (Moutan bark)(8.1%)
h. Ze Xie (Alisma rhizome) (8.1%)

C.3. Spleen-Yang and Kidney-Yang Deficiency  
Fatigue, edema, puffy, brittle hair, menstrual disorder, digestive disorder 2. Formula
Ling Gui Zhu Gan Tang used to transforms Phlegm-fluids, strengthen Spleen, clear Damp
a. Fu Ling (sclerotium poriae cocos) 12g
b. Gui Zhi (ramulus cinnamomi cassiae) 9g
c. Bai Zhu (rhizoma atracylodis macrocephalae) 6g
d. Zhi Gan Cao (honey fried radix glycyrrhizae uralensis) 6g

+ Shen Ling Bai Zhu San used to nourish Spleen, enhance the digestive function and removes Dampness
e. Ren Shen (Radix Ginseng)
f. Fu Ling (Sclerotium Poriae Cocos)
g. Bai Zhu (Rhizoma Atractylodis Macrocephalae)
h. Shan Yao (Rhizoma Dioscoreae Opposita)
i. Lian Zi (Semen Nelumbinis Nuciferae)
j. Bai Bian Dou (Semen Dolichoris Lablab)
k. Yi Yi Ren (Semen Coicis Lachryma-Jobi)
l. Sha Ren (Fructus Amomi)
m. Jie Geng (Radix Platycodi Grandiflori)
n. Gan Cao (Radix Glycyrrhizae Uralensis)

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Author note: the article is for information and education only, please consult with your doctor or related field specialist before applying.

Sources
(54) http://www.chinesemedicinetools.com/theory/treatment-diseases/general/systemic-lupus-erythematosus-treatment