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Friday, 29 November 2013

Cerebritis, Lupus, and Lupus Cerebritis - Risk Factors

Cerebritis is defined as an inflammation of the cerebrum, a structure associated with memory, speech, etc., as a result of the formation of an abscess within the brain itself, found commonly in patients with lupus.

Systemic lupus erythematosus (SLE) or Lupus is a chronic, autoimmune disease as as a result of the development of autoantibodies that attack the systems and organs in the body.researchers at the indicated that saturated fatty acid palmitate, but not unsaturated oleate, induces the activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1β and IL-18 production.

Lupus cerebritis is a disorder of nervous system problems (an autoimmune inflammatory disorder) caused by lupus as as a result of the development of autoantibodies that attack the systems and organs in the body. It causes migraine headache, if the duration of the central nervous system involvement last for a few minutes, or causes dementia that can lead to neurological deficits as a transient attacks or permanently.
risk factors
1.  Ultraviolet light 
exposure to ultraviolet light increases the risk of as it can exacerbate lupus by modulation of the immune system at the level of the skin. It has also been found that ultraviolet light can lead to the formation of antinuclear antibodies.(8)

2. Pegylated interferon therapy
People who are in treatment with  receiving pegylated interferon monotherapy may increase the risk of Lupus activation with cerebritis(9)

3. Gene mutation 
An international team of researchers led by Chaim O. Jacob, associate professor of medicine and microbiology & immunology at the Keck School of Medicine of USC, has identified a gene mutation involved in causing lupus, a chronic inflammatory disease that affects the skin, joints and organs, posted in the Dec. 26 online edition of the Proceedings of the National Academy of Sciences.(19)

4. Other risk factors
Risk factors were more present in bacterial infections of the nervous system and cerebrit than in virus infection of CNS. In virus infections of the CNS, 28% of patients had some risk factor, most often-chronic ethylism[1], diabetes mellitus[2] and acquired heart diseases[3]. In bacterial infections of the CNS, 64% of patients had some predisposed factor. The most frequent factor of risk in these patients were chronic otitis[4] (21.6%) and cranio-trauma[5] (14.4%). In cerebritis, risk factors were present in 76% of patients and they were: sepsis[6] (20%), chronic otitis[7] (12%) and systemic lupus erythematosus[8] (8%).(10)
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Sources
(8) http://www.ncbi.nlm.nih.gov/pubmed/20001946
(9) http://www.ncbi.nlm.nih.gov/pubmed/19776782
(10) http://www.ncbi.nlm.nih.gov/pubmed/20391743