Obesity and type 2 diabetes (T2DM) and level of lysophosphatidylcholine (LPC)

In the investigation of the plasma lipidomic analysis in a rodent model of obesity and insulin resistance as well as in lean, obese and obese individuals with T2DM, showed that Irrespective of species, our lipidomic profiling revealed a generalized decrease in circulating LPC species in states of obesity. Moreover, our data indicate that diet and adiposity, rather than insulin resistance or diabetes per se, play an important role in altering the plasma LPC profile(1).

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(1) "Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes"by Barber MN, Risis S, Yang C, Meikle PJ, Staples M, Febbraio MA, Bruce CR.