Weight Loss and Very Low Calorie Diet

In the investigation of investigate the effect of weight loss due to a very low calorie diet (VLCD) on insulin sensitivity and IL-6 serum levels in nondiabetic obese human individuals. 10 patients with obesity were examined during 12 weeks of a VLCD (800 kcal/d). Body composition was measured by impedance analysis, found that despite improvement of insulin sensitivity, IL-6 serum levels did not change throughout the study period, suggesting that in nondiabetic obese human subjects IL-6 might have only a minor role in the impairment of insulin sensitivity.

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(1) "Weight Loss Due to a Very Low Calorie Diet Differentially Affects Insulin Sensitivity and Interleukin-6 Serum Levels in Nondiabetic Obese Human Subjects" by Oberhauser F, Schulte DM, Faust M, Güdelhöfer H, Hahn M, Müller N, Neumann K, Krone W, Laudes M.