Precocious Puberty
I. Precocious Puberty refers to the sexual and physical characteristics mature occurring at an unusually early age such as before age 7 or 8 in girls and age 9 for boys.
Understand the process of puberty
The process of puberty begins with production of
gonadotropin-releasing hormone (Gn-RH) from the brain, which in turn
stimulates the pituitary gland to produce the luteinizing hormone (LH)
and follicle-stimulating hormone (FSH). These two hormones again
stimulates the ovaries in girls and testicles in boys to produce
estrogen and testosterone responsible for the growth and development of
girl and male sexual characteristics respectfully.
II. Causes
II.A. Central precocious puberty
Central precocious puberty can be caused by abnormal function of
hypothalamus in secretion of high-amplitude pulses of
gonadotropin-releasing hormone (GnRH) by the hypothalamus, leading to
high amount of female sexual characteristic, causing precocious puberty.
The high-amipliyude pulse of gonadotropin-releasing hormone (GnRH) by the hypothalamus can be result of
1. Damage to the inhibitory system of the brain as a result of infection, trauma, or irradiation.
2. McCune-Albright syndrome that effects the hormonal production.
3. Injure to the central nervous system
Injure to the central nervous system can result in disruption of
production of certain hormones which can contribute to onset of early
poverty.
4. Congenital adrenal hyperplasia due to inherited disorders causing the abnormal hormone production by the adrenal glands.
5. Congenital hypothyroidism
In the study of Precocious puberty with congenital hypothyroidism by
Abdelrahman M Radaideh, Mohamad Nusier, Zeyad El-Akawi & Duried
Jaradat, resaerchers conclude that where vaginal bleeding occurs in
young girls,hypothyroidism should be considered especially when vaginal
bleeding is accompanied with additional clinical presentations such as
short stature, delayed boneage and multicystic ovaries. Thyroxin
replacement therapy should lead to complete resolution of suchdisorder
and promote normal physical and mental development of young girls.
6. Hypothalamic hamartoma
in an article of Precocious Puberty and Hypothalamic Hamartoma by Hillel I. Hochman, David M. Judge, Seymour Reichlin,
indicated that The clinical, endocrinologic, and pathologic features of
published cases of precocious puberty and
hypothalamic hamartoma are reviewed. Advanced or rapidly progressive
true precocious puberty in the very young with
elevated concentrations of blood gonadotropins and gonadal steroids and
positive pneumoencephalography appear to be
characteristic.
7. Etc.
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