Saturday 2 November 2013

Chinese Herbs – Tu Si Zi (Semen Cuscutae Chinensis)

Tu Si Zi is also known as Dodder Seed. The acrid, sweet and  neutral herb has been used in TCM to treat  psychological disorder, calm the fetus, prevent miscarriage, etc. as it tonifies kidneys, liver and spleen, improves yin, etc. by enhancing the functions of liver and kidney channels.

Ingredients
1. Quercetin 3-O-beta-D-galactoside-7-O-beta-D-glucoside
2. Quercetin 3-O-beta-D-apiofuranosyl-(1–>2)-beta-D-galactoside
3. Hyperoside
4. Quercetin
5. Kaempferol
6. 2′-hydroxyl asarinin 2′-O-β-D-glucopyranoside (cuscutoside C, 1)
7. 2′-hydroxyl asarinin 2′-O-β-D-apiofuranosyl-(1 → 2)-[β-D-glucopyranosyl-(1 → 6)]-β-D-glucopyranoside (cuscutoside D, 2)
8. Etc.

Health Benefits
1. Ovarian endocrine functions
In the study to investigate  the mechanism of flavonoids from Semen Cuscutae (FSC) improving the ovarian endocrine functions, showed that SC decreases the contents of beta-EP in hypothalamuses and increases contents of LH in anterior pituitaries in female rats exposed to psychologic stress, which may be one of the mechanism of FSC improving hypothalamus-pituitary-ovary axis(1).
2. Osteoblastic bone formation
In the study to evaluate whether the aqueous extract of To-Sa-Za (TSZ-AE), the seed of Cuscuta chinensis Lam in osteogenic activity in human osteoblast-like MG-63 cells, showed that TSZ-AE enhanced ALP activity, collagen synthesis, BMP-2 expression, and mineralization in MG-63 cells. These results strongly, this suggest that C. chinensis can play an important role in osteoblastic bone formation and may possibly lead to the development of bone-forming drugs.
3. Hepatoprotective and antioxidant effects
Tu-Si-Zi, the seeds of Cuscuta chinensis Lam. (Convolvulaceae), is a traditional Chinese medicine that is commonly used to nourish and improve the liver and kidney conditions in China and other Asian countries. In the study of hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats, researchers at the Kaohsiung Medical University, Kaohsiung indicated that the ethanolic extract of Cuscuta chinensis can prevent hepatic injuries from APAP-induced hepatotoxicity in rats and this is likely mediated through its antioxidant activities(3).
4.  Immune enhancement, anti-fatigue and anoxia tolerance
In the st5udy to investigate the effects of immune enhancement, anti-fatigue and anoxia tolerance on mice of four kinds of dodder seeds in Shandong Province, showed that they enhance the phagocytosis of macrophage of mice and increase the weights of thymus and spleen of the immature mice. They could prolong the survival time of mice swimming and lacking oxygen. Cuscuta chinensis Lam. and C. australis R. Br. had better effects than the other two kinds, and the water extracts had better effects than alcohol extracts(4).
5. Etc.

Side Effects
1. Do not use the herb in case of blood deficiency and  Yin deficiency with Fire
2. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
3. Etc.

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/12685350
(2) http://www.ncbi.nlm.nih.gov/pubmed/19298200
(3) http://www.ncbi.nlm.nih.gov/pubmed/17145147
(4) http://www.ncbi.nlm.nih.gov/pubmed/15339618

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