Sheng Ma is also known as Bugbane Rhizome. The
sweet, acrid and slightly cold herb has been used in TCM to treat
influenza, measles, sore and swollen throat, toothache, gingivitis,
swollen eyes, dull headache, migraine, hemorrhoids, etc., as it
releases the Exterior, promotes the eruption of exanthema, clears Heat,
expels toxins, raises Yang to avoid its collapse, etc. by enhancing the
functions of lung, spleen, large intestine and stomach channels.
Ingredients
1. Cimitin
2. Cimigenol
3. Visnagin
4. Visamminol
5. Indole
6. Alkaloids
7. Cimicifugine
8. B-sitosterol
9. Cimigenol xyloside
10. Dahurinol
11. Isodahurinol
12. Dehydroxydahurino
13. Etc.
Health Benefits
1. Antiosteoporotic effect
In the study of the effects of Cimicifuga heracleifolia (CH), an Asian species of Cimicifugae rhizome, on bone loss in ovariectomized (OVX) mice, showed that treatment with CH (i.p., 50 mg/kg of body weight, every other day) prevented the OVX-induced increase in body weight but did not alter the uterus weight of the OVX mice. Serum ALP levels and osteoclast surface levels in the OVX mice were reduced by treatment with CH. The CH significantly preserved trabecular bone mass, bone volume, trabecular number, trabecular thickness, structure model index and bone mineral density of proximal tibia metaphysis or distal femur metaphysis(1).
2. Antioxidant activity
In the study to investigate the effect of Isoferulic acid (3-hydroxy-4-methoxycinnamic acid, IFA), the isomer of ferulic acid (4-hydroxy-3-methoxycinnamic acid), is a rare phenolic acid occurring in Rhizoma Cimicifugae, indicated that DPPH (1,1-diphenyl-2-picrylhydrazyl radical) and ABTS (3-ethylbenzthiazoline-6-sulfonic acid diammonium salt) radical scavenging, reducing power on Fe3+ and CU2+ ions, and hydroxyl and superoxide anion radical scavenging(2).
3. Anthelmintic effects
In the assessment of petroleum ether, chloroform, ethyl acetate, methanol, and water extracts of Prunus amygdalus Batsch seeds (Semen amygdali), Cimicifuga foetida L. rhizomes (Rhizoma Cimicifugae), Peucedanum decursivum (Miq.) Maxim roots (Radix Peucedani), Momordica cochinchinensis Spreng. seeds (Semen Momordicae), and Bupleurum chinense DC. roots (Radix Bupleuri chinensis) for their in vivo anthelmintic activity against monogenean Dactylogyrus intermedius in goldfish (Carassius auratus), found that the efficacies of methanol, chloroform, and ethyl acetate extracts from R. Bupleuri chinensis were found to be, in this order, more effective than others with the 48 h-EC(50) and EC(90) values of 3.5 and 6.9, 6.0 and 8.4, 7.4 and 11.2 mg/L, respectively, followed by ethyl acetate extract of R. cimicifugae and chloroform extract of R. peucedani with EC(50) 189.2 and 240.4 mg/L. The promising methanol, chloroform, and ethyl acetate extracts from R. Bupleuri chinensis were subjected to acute toxicity tests for the evaluation of their safety to the host. After 48-h exposure, the mortalities of goldfish were recorded, and the established LC(50) values were 10.1-, 4.2-, and 8.4-fold higher than the corresponding EC(50)(3).
4. Atherosclerosis
In the avaluation of 7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells, researchers found that upregualtion of PPAR-γ by 7,8-DHC in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression. In addition, ERK1/2 and Akt signal pathways are involved in differential regulation by 7,8-DHC and concluded that 7,8-DHC can be used for the treatment of cardiovascular disorders such as atherosclerosis(4).
5. Antibacterial activity
In the study to observe 20 traditional Chinese medicines (TCM) were evaluated for their antimicrobial activity against four common oral bacteria, showed that Thirteen TCMs demonstrated antimicrobial activity against Porphyromonas gingivalis, including Cortex magnoliae officinalis, Cortex phellodendri, Flos caryophylli, Flos lonicerae japonicae, Fructus armeniaca mume, Fructus forsythiae suspensae, Herba cum radice violae yedoensitis, Herba menthae haplocalycis, Pericarpium granati, Radix et rhizoma rhei, Radix gentianae, Ramulus cinnamomi cassia and Rhizoma cimicifugae. Cortex phellodendri showed antimicrobial activity against Streptococcus mutans, while Radix et rhizoma rhei was effective against Streptococcus mitis and Streptococcus sanguis. Fructus armeniaca mume had inhibitory effects against Streptococcus mitis, Streptococcus sanguis, Streptococcus mutans and Porphyromonas gingivalis in vitro(5).
6. Anti inflammatory effects
In the study to assess the insights into the mechanism of action regarding analgesic and antiinflammatory activities of Rhizoma cimicifugae (RC) extracts(fractionated to an ether-soluble fraction (B) and a water-soluble fraction (C). Fraction C was fractionated to a butanol-soluble fraction (D) and a water-soluble fraction (E). Each fraction (100 mg/kg, i.p.), researchers found that fractions A, D and E exerted antiinflammatory effects on the rat paw oedema assay. The fractions A, D, E had an inhibitory action on the bradykinin/histamine-mediated contractions of guinea-pig ileum. In addition, fractions A, D and E had the ability to inhibit the production of LPS-induced 6-keto-PGF1alpha production in macrophage cultures. Taken together, these results provide scientific evidence that RC extracts exert analgesic and antiinflammatory effects by inhibiting bradykinin/histamine mediated actions and inhibiting 6-keto-PGF1alpha induction(6).
7. Etc.
Side Effects
1. Do not use in case ripen measles
2. Do not use in case of breathing difficulty as a result of heat from lung deficiency
3. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
4. Etc.
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21987388
(2) http://www.ncbi.nlm.nih.gov/pubmed/21941899
(3) http://www.ncbi.nlm.nih.gov/pubmed/21153837
(4) http://www.ncbi.nlm.nih.gov/pubmed/20946932
(5) http://www.ncbi.nlm.nih.gov/pubmed/20418062
(6) http://www.ncbi.nlm.nih.gov/pubmed/11113994
Ingredients
1. Cimitin
2. Cimigenol
3. Visnagin
4. Visamminol
5. Indole
6. Alkaloids
7. Cimicifugine
8. B-sitosterol
9. Cimigenol xyloside
10. Dahurinol
11. Isodahurinol
12. Dehydroxydahurino
13. Etc.
Health Benefits
1. Antiosteoporotic effect
In the study of the effects of Cimicifuga heracleifolia (CH), an Asian species of Cimicifugae rhizome, on bone loss in ovariectomized (OVX) mice, showed that treatment with CH (i.p., 50 mg/kg of body weight, every other day) prevented the OVX-induced increase in body weight but did not alter the uterus weight of the OVX mice. Serum ALP levels and osteoclast surface levels in the OVX mice were reduced by treatment with CH. The CH significantly preserved trabecular bone mass, bone volume, trabecular number, trabecular thickness, structure model index and bone mineral density of proximal tibia metaphysis or distal femur metaphysis(1).
2. Antioxidant activity
In the study to investigate the effect of Isoferulic acid (3-hydroxy-4-methoxycinnamic acid, IFA), the isomer of ferulic acid (4-hydroxy-3-methoxycinnamic acid), is a rare phenolic acid occurring in Rhizoma Cimicifugae, indicated that DPPH (1,1-diphenyl-2-picrylhydrazyl radical) and ABTS (3-ethylbenzthiazoline-6-sulfonic acid diammonium salt) radical scavenging, reducing power on Fe3+ and CU2+ ions, and hydroxyl and superoxide anion radical scavenging(2).
3. Anthelmintic effects
In the assessment of petroleum ether, chloroform, ethyl acetate, methanol, and water extracts of Prunus amygdalus Batsch seeds (Semen amygdali), Cimicifuga foetida L. rhizomes (Rhizoma Cimicifugae), Peucedanum decursivum (Miq.) Maxim roots (Radix Peucedani), Momordica cochinchinensis Spreng. seeds (Semen Momordicae), and Bupleurum chinense DC. roots (Radix Bupleuri chinensis) for their in vivo anthelmintic activity against monogenean Dactylogyrus intermedius in goldfish (Carassius auratus), found that the efficacies of methanol, chloroform, and ethyl acetate extracts from R. Bupleuri chinensis were found to be, in this order, more effective than others with the 48 h-EC(50) and EC(90) values of 3.5 and 6.9, 6.0 and 8.4, 7.4 and 11.2 mg/L, respectively, followed by ethyl acetate extract of R. cimicifugae and chloroform extract of R. peucedani with EC(50) 189.2 and 240.4 mg/L. The promising methanol, chloroform, and ethyl acetate extracts from R. Bupleuri chinensis were subjected to acute toxicity tests for the evaluation of their safety to the host. After 48-h exposure, the mortalities of goldfish were recorded, and the established LC(50) values were 10.1-, 4.2-, and 8.4-fold higher than the corresponding EC(50)(3).
4. Atherosclerosis
In the avaluation of 7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells, researchers found that upregualtion of PPAR-γ by 7,8-DHC in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression. In addition, ERK1/2 and Akt signal pathways are involved in differential regulation by 7,8-DHC and concluded that 7,8-DHC can be used for the treatment of cardiovascular disorders such as atherosclerosis(4).
5. Antibacterial activity
In the study to observe 20 traditional Chinese medicines (TCM) were evaluated for their antimicrobial activity against four common oral bacteria, showed that Thirteen TCMs demonstrated antimicrobial activity against Porphyromonas gingivalis, including Cortex magnoliae officinalis, Cortex phellodendri, Flos caryophylli, Flos lonicerae japonicae, Fructus armeniaca mume, Fructus forsythiae suspensae, Herba cum radice violae yedoensitis, Herba menthae haplocalycis, Pericarpium granati, Radix et rhizoma rhei, Radix gentianae, Ramulus cinnamomi cassia and Rhizoma cimicifugae. Cortex phellodendri showed antimicrobial activity against Streptococcus mutans, while Radix et rhizoma rhei was effective against Streptococcus mitis and Streptococcus sanguis. Fructus armeniaca mume had inhibitory effects against Streptococcus mitis, Streptococcus sanguis, Streptococcus mutans and Porphyromonas gingivalis in vitro(5).
6. Anti inflammatory effects
In the study to assess the insights into the mechanism of action regarding analgesic and antiinflammatory activities of Rhizoma cimicifugae (RC) extracts(fractionated to an ether-soluble fraction (B) and a water-soluble fraction (C). Fraction C was fractionated to a butanol-soluble fraction (D) and a water-soluble fraction (E). Each fraction (100 mg/kg, i.p.), researchers found that fractions A, D and E exerted antiinflammatory effects on the rat paw oedema assay. The fractions A, D, E had an inhibitory action on the bradykinin/histamine-mediated contractions of guinea-pig ileum. In addition, fractions A, D and E had the ability to inhibit the production of LPS-induced 6-keto-PGF1alpha production in macrophage cultures. Taken together, these results provide scientific evidence that RC extracts exert analgesic and antiinflammatory effects by inhibiting bradykinin/histamine mediated actions and inhibiting 6-keto-PGF1alpha induction(6).
7. Etc.
Side Effects
1. Do not use in case ripen measles
2. Do not use in case of breathing difficulty as a result of heat from lung deficiency
3. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
4. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Back to Popular Chinese Herbs http://kylejnorton.blogspot.ca/p/chinese-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Back to Popular Chinese Herbs http://kylejnorton.blogspot.ca/p/chinese-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21987388
(2) http://www.ncbi.nlm.nih.gov/pubmed/21941899
(3) http://www.ncbi.nlm.nih.gov/pubmed/21153837
(4) http://www.ncbi.nlm.nih.gov/pubmed/20946932
(5) http://www.ncbi.nlm.nih.gov/pubmed/20418062
(6) http://www.ncbi.nlm.nih.gov/pubmed/11113994
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