Huang Bai or Huang Po is also known as amur
cork-tree bark. The bitter and cold herb has been used in TCM to treat
vaginal bacterial infection or yeast infection, swollen knees, legs and
feet, spermatorrhea. night sweat, lower blood pressure, etc., as it
clears Heat, dries Dampness; disperses Fire, expels toxins, etc/, by
enhancing the functions of Kidney and Bladder channels.
Ingredients
1. Berberine
2. Jatorrhizine
3. Magnoflorine
4. Phellodendrine
5. Candicine
6. Palmatine
7. Menisperine
8. Obaculactone
9. Obacunone
10. Obacunonic acid
11. β-sitosterol
12. Campesterol
13. Etc.
1. Berberine
2. Jatorrhizine
3. Magnoflorine
4. Phellodendrine
5. Candicine
6. Palmatine
7. Menisperine
8. Obaculactone
9. Obacunone
10. Obacunonic acid
11. β-sitosterol
12. Campesterol
13. Etc.
Health Benefits
1. Anti-inflammatory
In the investigation of the anti-inflammatory effect of ethanol extracts of Cortex Phellodendri Chinensis (ECPC) and Cortex Phellodendri Amurensis (ECPA) by measuring the ear thickness, activity of myeloperoxidase (MPO) and the production reactive oxygen species (ROS), found that both ECPC and ECPA have potential anti-inflammatory effect on TPA-induced inflammatory in mice, and ECPC is more effective than ECPA. The anti-inflammatory effect of the herbal drugs may be mediated, at least in part, by down-regulating the mRNA expression of a panel of inflammatory mediators including TNF-α, IL-1β, IL-6 and COX-2, according to “Comparison on the anti-inflammatory effect of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice” by Xian YF, Mao QQ, Ip SP, Lin ZX, Che CT.(1) 2. Anti-heat stress
In the evaluation of the effects on immune function of four herbal extracts from Agastache rugosa, Atractylodes lancea, Cortex Phellodendri, and Gypsum Fibrosum on heat treated splenic lymphocytes on splenic lymphocytes under HS as well as its compatibility, showed that Atractylodes lancea (200 μg/mL), Cortex Phellodendri (100 μg/mL) and Gypsum Fibrosum (100 μg/mL) were the optimal conditions for the prescription. The validation experiment confirmed that our composition in optimum extraction conditions enhanced effects on ConA or LPS-stimulated lymphocytes under HS. The results showed that the Taguchi optimization approach is a suitable method for optimization of the composition of prescription, according to”Taguchi approach for anti-heat stress prescription compatibility in mice spleen lymphocytes in vitro” byZhu XY, Cheng GL, Liu FH, Yu J, Wang YJ, Yu TQ, Xu JQ, Wang M.(2)
3. Antioxidants
In the study of the regulatory functions of the active components of TCM and elucidation of the effects of different TCM decoctions on antioxidant activity and lipid peroxide content, using in vitro and in vivo, indicated that in vivo experiments demonstrated that TCM1(COP, RA, AR, and GF (1:1:1:1, TCM1)) and COP, RA, AR, and GF (1:1:1:0.5, TCM2) TCM2 improved (P < 0.05) the poor growth performance seen in HTG pigs. The superoxide dismutase, glutathione peroxidase activities, and malondialdehyde content in porcine jejunum treated with TCM1 and TCM2 were not different (P > 0.05) from those seen in the NTG and were better (P < 0.05) than results seen in the HTG. Overall, it appeared that TCM2 was more effective than TCM1 in ameliorating the effects of heat stress in pigs. In conclusion, this study revealed that the active components of common TCM decoctions have antioxidant functions, according to “Active components of common traditional Chinese medicine decoctions have antioxidant functions” byGuo KJ, Xu SF, Yin P, Wang W, Song XZ, Liu FH, Xu JQ, Zoccarato I.(3)
4. Antiobesity and metabolic syndrome
In the investigation of the effects of 50 commonly used Kampo medicines on the differentiation of 3T3-L1 preadipocytes to search for a drug with an antiobesity effect, found that the differentiation-inhibitory effect of Orengedokuto was accounted for by Coptidis rhizome and Phellodendri cortex. Furthermore, berberine, a principal ingredient common to Coptidis rhizome and Phellodendri cortex, showed a differentiation-inhibitory effect. The effect of berberine involves an inhibition of the mRNA and protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα), according to “Inhibition of preadipocyte differentiation and lipid accumulation by Orengedokuto treatment of 3T3-L1 cultures” by Ikarashi N, Tajima M, Suzuki K, Toda T, Ito K, Ochiai W, Sugiyama K.(4)
5. HIV/AIDS
In the consideration of the first-choice agents for treatment and prevention because of their relatively low side effects and high effectiveness on mucosal infections, found that crude extracts from a number of medicinal herbs (cortex moutan, cortex pseudolaricis, rhizoma alpiniae officinarum, rhizoma coptidis, clove and cinnamon, anemarrhena cortex phellodendri, ramulus cinnamomi, and Chinese gall.) have been shown to exhibit antifungal activities in vitro. The effective anti-Candida principals were identified to be berberine, palmatine, allincin, pseudolaric acid A and B, magnolol, honokiol, and galangin. Thus, traditional Chinese medicinal herbs provide abundant choices for the treatment of refractory candidiasis commonly seen in HIV/AIDS patients. However, there remains a need for further screening of effective extracts and for study of the antifungal mechanisms involved. Importantly, ahead of clinical application, the safety of these compounds must be firmly established, according to “Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS” by Liu X, Han Y, Peng K, Liu Y, Li J, Liu H.(5)
6. Antimicrobial activity
In the determination of the anti microbial effect of Streptococcus mitis, Streptococcus sanguis, Streptococcus mutans and Porphyromonas gingivalis from twenty traditional Chinese medicines (TCM), indicated that Fructus armeniaca mume was effective against all four bacteria. Thirteen TCMs demonstrated antimicrobial activity against Porphyromonas gingivalis, including Cortex magnoliae officinalis, Cortex phellodendri, Flos caryophylli, Flos lonicerae japonicae, Fructus armeniaca mume, Fructus forsythiae suspensae, Herba cum radice violae yedoensitis, Herba menthae haplocalycis, Pericarpium granati, Radix et rhizoma rhei, Radix gentianae, Ramulus cinnamomi cassia and Rhizoma cimicifugae. Cortex phellodendri showed antimicrobial activity against Streptococcus mutans, while Radix et rhizoma rhei was effective against Streptococcus mitis and Streptococcus sanguis. Fructus armeniaca mume had inhibitory effects against Streptococcus mitis, Streptococcus sanguis, Streptococcus mutans and Porphyromonas, gingivalis in vitro, according to “Antimicrobial activity of Chinese medicine herbs against common bacteria in oral biofilm. A pilot study?” by Wong RW, Hägg U, Samaranayake L, Yuen MK, Seneviratne CJ, Kao R.(6)
7. Etc.
1. Anti-inflammatory
In the investigation of the anti-inflammatory effect of ethanol extracts of Cortex Phellodendri Chinensis (ECPC) and Cortex Phellodendri Amurensis (ECPA) by measuring the ear thickness, activity of myeloperoxidase (MPO) and the production reactive oxygen species (ROS), found that both ECPC and ECPA have potential anti-inflammatory effect on TPA-induced inflammatory in mice, and ECPC is more effective than ECPA. The anti-inflammatory effect of the herbal drugs may be mediated, at least in part, by down-regulating the mRNA expression of a panel of inflammatory mediators including TNF-α, IL-1β, IL-6 and COX-2, according to “Comparison on the anti-inflammatory effect of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice” by Xian YF, Mao QQ, Ip SP, Lin ZX, Che CT.(1) 2. Anti-heat stress
In the evaluation of the effects on immune function of four herbal extracts from Agastache rugosa, Atractylodes lancea, Cortex Phellodendri, and Gypsum Fibrosum on heat treated splenic lymphocytes on splenic lymphocytes under HS as well as its compatibility, showed that Atractylodes lancea (200 μg/mL), Cortex Phellodendri (100 μg/mL) and Gypsum Fibrosum (100 μg/mL) were the optimal conditions for the prescription. The validation experiment confirmed that our composition in optimum extraction conditions enhanced effects on ConA or LPS-stimulated lymphocytes under HS. The results showed that the Taguchi optimization approach is a suitable method for optimization of the composition of prescription, according to”Taguchi approach for anti-heat stress prescription compatibility in mice spleen lymphocytes in vitro” byZhu XY, Cheng GL, Liu FH, Yu J, Wang YJ, Yu TQ, Xu JQ, Wang M.(2)
3. Antioxidants
In the study of the regulatory functions of the active components of TCM and elucidation of the effects of different TCM decoctions on antioxidant activity and lipid peroxide content, using in vitro and in vivo, indicated that in vivo experiments demonstrated that TCM1(COP, RA, AR, and GF (1:1:1:1, TCM1)) and COP, RA, AR, and GF (1:1:1:0.5, TCM2) TCM2 improved (P < 0.05) the poor growth performance seen in HTG pigs. The superoxide dismutase, glutathione peroxidase activities, and malondialdehyde content in porcine jejunum treated with TCM1 and TCM2 were not different (P > 0.05) from those seen in the NTG and were better (P < 0.05) than results seen in the HTG. Overall, it appeared that TCM2 was more effective than TCM1 in ameliorating the effects of heat stress in pigs. In conclusion, this study revealed that the active components of common TCM decoctions have antioxidant functions, according to “Active components of common traditional Chinese medicine decoctions have antioxidant functions” byGuo KJ, Xu SF, Yin P, Wang W, Song XZ, Liu FH, Xu JQ, Zoccarato I.(3)
4. Antiobesity and metabolic syndrome
In the investigation of the effects of 50 commonly used Kampo medicines on the differentiation of 3T3-L1 preadipocytes to search for a drug with an antiobesity effect, found that the differentiation-inhibitory effect of Orengedokuto was accounted for by Coptidis rhizome and Phellodendri cortex. Furthermore, berberine, a principal ingredient common to Coptidis rhizome and Phellodendri cortex, showed a differentiation-inhibitory effect. The effect of berberine involves an inhibition of the mRNA and protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα), according to “Inhibition of preadipocyte differentiation and lipid accumulation by Orengedokuto treatment of 3T3-L1 cultures” by Ikarashi N, Tajima M, Suzuki K, Toda T, Ito K, Ochiai W, Sugiyama K.(4)
5. HIV/AIDS
In the consideration of the first-choice agents for treatment and prevention because of their relatively low side effects and high effectiveness on mucosal infections, found that crude extracts from a number of medicinal herbs (cortex moutan, cortex pseudolaricis, rhizoma alpiniae officinarum, rhizoma coptidis, clove and cinnamon, anemarrhena cortex phellodendri, ramulus cinnamomi, and Chinese gall.) have been shown to exhibit antifungal activities in vitro. The effective anti-Candida principals were identified to be berberine, palmatine, allincin, pseudolaric acid A and B, magnolol, honokiol, and galangin. Thus, traditional Chinese medicinal herbs provide abundant choices for the treatment of refractory candidiasis commonly seen in HIV/AIDS patients. However, there remains a need for further screening of effective extracts and for study of the antifungal mechanisms involved. Importantly, ahead of clinical application, the safety of these compounds must be firmly established, according to “Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS” by Liu X, Han Y, Peng K, Liu Y, Li J, Liu H.(5)
6. Antimicrobial activity
In the determination of the anti microbial effect of Streptococcus mitis, Streptococcus sanguis, Streptococcus mutans and Porphyromonas gingivalis from twenty traditional Chinese medicines (TCM), indicated that Fructus armeniaca mume was effective against all four bacteria. Thirteen TCMs demonstrated antimicrobial activity against Porphyromonas gingivalis, including Cortex magnoliae officinalis, Cortex phellodendri, Flos caryophylli, Flos lonicerae japonicae, Fructus armeniaca mume, Fructus forsythiae suspensae, Herba cum radice violae yedoensitis, Herba menthae haplocalycis, Pericarpium granati, Radix et rhizoma rhei, Radix gentianae, Ramulus cinnamomi cassia and Rhizoma cimicifugae. Cortex phellodendri showed antimicrobial activity against Streptococcus mutans, while Radix et rhizoma rhei was effective against Streptococcus mitis and Streptococcus sanguis. Fructus armeniaca mume had inhibitory effects against Streptococcus mitis, Streptococcus sanguis, Streptococcus mutans and Porphyromonas, gingivalis in vitro, according to “Antimicrobial activity of Chinese medicine herbs against common bacteria in oral biofilm. A pilot study?” by Wong RW, Hägg U, Samaranayake L, Yuen MK, Seneviratne CJ, Kao R.(6)
7. Etc.
Side effects
1. Do not use the herb in case of Spleen deficiency2. Do not use Huang Bai if you are ecperience weak digestion, lack of appetite.
3. Do not use the Huang Bai in newborn, children or if you are pregnant or breast feeding with out approval first with the related field specialist
4. Etc.
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21875660
(2) http://www.ncbi.nlm.nih.gov/pubmed/21811919
(3) http://www.ncbi.nlm.nih.gov/pubmed/21571894
(4) http://www.ncbi.nlm.nih.gov/pubmed/21557367
(5) http://www.ncbi.nlm.nih.gov/pubmed/21441482
(6) http://www.ncbi.nlm.nih.gov/pubmed/20418062
Isoxanthohumol is a derivative of xanthohumol in the flavonoids class. It is isolated from the the roots of Sophora flavescens Ait. Isoxanthohumol exhibits antioxidant, anti-inflammatory and antiangiogenic properties. Isoxanthohumol induces apoptosis in mature adipocytes, and inhibits differentiation of preadipocytes. Isoxanthohumol
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