Cerebritis is defined as an inflammation of the cerebrum, a structure associated with memory, speech, etc., as a result of the formation of an abscess within the brain itself, found commonly in patients with lupus.
Systemic lupus
erythematosus (SLE) or Lupus is a chronic, autoimmune
disease as as a result of the development of
autoantibodies that attack the systems and organs in the
body.researchers at the indicated that saturated fatty acid palmitate,
but not unsaturated oleate, induces the
activation of the NLRP3-ASC inflammasome, causing caspase-1, IL-1β and
IL-18 production.
Lupus
cerebritis is a disorder of nervous system problems (an autoimmune
inflammatory disorder) caused
by lupus as as a result of the development of
autoantibodies that attack the systems and organs in the body. It causes
migraine headache, if the duration of the
central nervous system involvement last for a few minutes, or causes
dementia that can lead to neurological deficits as a transient attacks
or permanently.
risk factors
1. Ultraviolet light
exposure to ultraviolet light increases the risk of as it can exacerbate lupus
by modulation of the immune system at the level of the skin. It has
also been found that ultraviolet light can lead to the formation of
antinuclear antibodies.(8)
2. Pegylated interferon therapy
People who are in treatment with receiving pegylated interferon monotherapy may increase the risk of Lupus activation with cerebritis(9)
3. Gene mutation
An international team of researchers led by Chaim O. Jacob, associate professor of medicine
and microbiology & immunology at the Keck School of Medicine of
USC, has identified a gene mutation involved in causing lupus, a chronic
inflammatory disease that affects the skin, joints and organs, posted in the Dec. 26 online edition of the Proceedings of the National Academy of Sciences.(19)
4. Other risk factors
Risk factors
were more present in bacterial infections of the nervous system and
cerebrit than in virus infection of CNS. In virus infections of the CNS,
28% of patients had some risk
factor, most often-chronic ethylism[1], diabetes mellitus[2] and acquired
heart diseases[3]. In bacterial infections of the CNS, 64% of patients had
some predisposed factor. The most frequent factor of risk in these patients were chronic otitis[4] (21.6%) and cranio-trauma[5] (14.4%). In cerebritis, risk factors were present in 76% of patients and they were: sepsis[6] (20%), chronic otitis[7] (12%) and systemic lupus erythematosus[8] (8%).(10)
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Sources
(8) http://www.ncbi.nlm.nih.gov/pubmed/20001946
(9) http://www.ncbi.nlm.nih.gov/pubmed/19776782
(10) http://www.ncbi.nlm.nih.gov/pubmed/20391743
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